Find hotels in South Central Houston, Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Central Houston hotels

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,129 reviews)
"Great central location within the walking distance to many places. "
United States
Kasey
The price is ₩267,850
₩333,392 total
includes taxes & fees
Mar 29 - Mar 30
The Westin Houston Medical Center/Museum District

Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
10.0 out of 10, Exceptional, (1 review)
"Jerrick (front desk) was super friendly and helpful, and the room and amenities were great."
United States
Cade
The price is ₩203,026
₩281,472 total
includes taxes & fees
Apr 8 - Apr 9
Sentral Forme Houston

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
8.4 out of 10, Very Good, (88 reviews)
"Good hotel. great location. "
United States
Porfirio
The price is ₩143,235
₩167,585 total
includes taxes & fees
Mar 29 - Mar 30
Downtowner Inns - Houston Downtown

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,006 reviews)
"Amazing hotel. Beautiful property, wonderful customer service."
United States
LATOYA
The price is ₩260,839
₩335,337 total
includes taxes & fees
Apr 5 - Apr 6
InterContinental Houston by IHG

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,928 reviews)
"Great vibe"
United States
Jennifer
The price is ₩394,756
₩532,880 total
includes taxes & fees
Mar 29 - Mar 30
Hotel Zaza Houston Museum District

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1,001 reviews)
"Very clean room, staff was very good, felt safe"
United States
Gayle
The price is ₩149,266
₩174,641 total
includes taxes & fees
Mar 28 - Mar 29
Americas Best Value Inn Medical Center Downtown

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (1,866 reviews)
"Very clean property, staff was helpful"
United States
Elton
The price is ₩164,344
₩194,032 total
includes taxes & fees
Apr 5 - Apr 6
Hilton Houston Plaza/Medical Center

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Everything was great "
United States
Casey
The price is ₩284,963
₩382,699 total
includes taxes & fees
Apr 4 - Apr 5
Houston Marriott Medical Center/Museum District

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (208 reviews)
"Thoroughly enjoyed our stay. Nick, the property manager is very nice and thoughtful. The bed was so comfortable and the best part for me was the incredibly private and quiet spaces. "
United States
Misty
The price is ₩310,962
₩386,358 total
includes taxes & fees
Apr 1 - Apr 2
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (564 reviews)
"Loved the area, the staff was super friendly and accomodating. "
United States
Silvia Alejandra
The price is ₩268,899
₩314,612 total
includes taxes & fees
Apr 15 - Apr 16
La Maison in Midtown an urban B&B

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (546 reviews)
"Breakfast was pricey"
United States
Thomas
The price is ₩162,112
₩189,671 total
includes taxes & fees
Apr 25 - Apr 26
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (66 reviews)
"Great location will stay again "
United States
Jason
The price is ₩192,146
₩224,819 total
includes taxes & fees
Apr 12 - Apr 13
Wanderstay Boutique Hotel

Paradise Palace Best Rooftop in HTX w Hot Tub

Paradise Palace Best Rooftop in HTX w Hot Tub
3.0 star property
South Central Houston
The price is ₩998,330
₩1,631,113 total
includes taxes & fees
Apr 24 - Apr 25
Paradise Palace Best Rooftop in HTX w Hot Tub

Rodeway Inn & Suites Houston near Medical Center

Rodeway Inn & Suites Houston near Medical Center
2.0 star property
South Central Houston
6.0 out of 10, (510 reviews)
"Very dirty place. No TV. Air conditioning did work."
United States
Gabriela
The price is ₩96,103
₩112,441 total
includes taxes & fees
Apr 26 - Apr 27
Rodeway Inn & Suites Houston near Medical Center

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (233 reviews)
"Quiet and comfortable rooms; good access to the area around. "
United States
Timothy
The price is ₩88,203
₩103,205 total
includes taxes & fees
Apr 1 - Apr 2
Southmore Boulevard Motel

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,000 reviews)
"Everything was great! "
United States
Trina
The price is ₩109,899
₩129,017 total
includes taxes & fees
Apr 5 - Apr 6
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (921 reviews)
"Booking was easy, staff was super friendly, and the location was perfect for what I needed! "
United States
Brandon
The price is ₩233,609
₩273,322 total
includes taxes & fees
Apr 13 - Apr 14
Hilton University of Houston

Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (1 review)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ₩85,941
₩100,551 total
includes taxes & fees
Mar 29 - Mar 30
Golden Motel Near Houston Medical Center

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very Good, (198 reviews)
"it was a great experience, staff was kind and helpful. "
United States
James
The price is ₩87,745
₩102,662 total
includes taxes & fees
Apr 8 - Apr 9
Wanderstay Houston Hostel

Houston 6 Bedroom Home

Houston 6 Bedroom Home
2.0 star property
South Central Houston
The price is ₩613,843
₩718,197 total
includes taxes & fees
Apr 1 - Apr 2
Houston 6 Bedroom Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
564 reviews
View
Reception
Wanderstay Boutique Hotel
2.0 star property
9.8
Exceptional
66 reviews
View
Outdoor pool, free cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,129 reviews
View
Exterior
InterContinental Houston by IHG
4.0 star property
9.2
Wonderful
1,006 reviews
View
Lobby
Hilton University of Houston
3.5 star property
9.0
Wonderful
921 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out Children's Museum of Houston and Houston Natural Science Museum as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, The Westin Houston Medical Center/Museum District is the highest ranked property in South Central Houston. This hotel is a short 7-minute walk from MD Anderson Cancer Center, and it offers a restaurant and an outdoor pool. Other favorite options in the area include MyCrib Houston Hostel and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1043 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Bagby Dog Park. Children's Museum of Houston and Houston Natural Science Museum are some other stops to visit in the neighborhood. Toyota Center and Daikin Park are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.