South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed art scene and lively festivals in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and entertainment choices in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the great live music and acclaimed theater scene in this vibrant area.
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
"A1"
Reviewed on Jun 1, 2026
Club Quarters Hotel Downtown, Houston
"Close to places visited. Desert place for price"
Reviewed on May 31, 2026
The Whitehall Houston
"The restaurant breakfast was very good. The room was clean and very nice."
Reviewed on May 29, 2026
Blossom Hotel Houston, Curio Collection by Hilton
"Jekdnrbrnrbr"
Reviewed on May 31, 2026
Grand Tuscany Hotel
"This is a huge hotel but not completely updated and they tried to charge us for parking at a rate of $10 dollars a day but they clearly had a sign that said parking was a courtesy to the guest of the hotel. Would like to know who was just pocketing the fees to park. Other guests were smoking Marijuana ..."
Reviewed on May 30, 2026
Hilton Houston Plaza/Medical Center
"My families stay was not a pleasant one. Initially we were given a room on the 12th floor. Everything appeared to be fine. However, we found out that the shower only sprayed scolding, hot water and the faucet where the coffee maker was at spewed the water in our faces. A maintenance person had to ..."
Reviewed on May 31, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Houston Zoo or Fertitta Center and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Fertitta Center or Barbara Jordan & Mickey Leland Archives, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
