A city skyline with modern buildings and a park with a lake.

Find hotels in South Main, Houston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for South Main hotels

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

1. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,003 reviews)
"Clean rooms and staff is great."
United States
Tamy
The price is ₩107,500
₩125,775 total
includes taxes & fees
Nov 4 - Nov 5
Comfort Suites Houston near Medical Center- NRG Stadium
A modern lobby with a blue carpet, seating area, and large windows.

2. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,456 reviews)
"Great stay!!"
United States
Matthew
The price is ₩119,630
₩139,971 total
includes taxes & fees
Oct 19 - Oct 20
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,000 reviews)
"We had a excellent stay"
United States
Jasmine
The price is ₩87,796
₩102,720 total
includes taxes & fees
Oct 29 - Oct 30
Quality Inn & Suites NRG Park - Medical Center
A spacious lobby with a central seating area, a bar, and a reception desk.

4. Wingate Houston near Reliant Park/Medical Center

Wingate Houston near Reliant Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,006 reviews)
"Great place"
United States
Crystal
The price is ₩119,496
₩139,809 total
includes taxes & fees
Oct 19 - Oct 20
Wingate Houston near Reliant Park/Medical Center
A courtyard with a pathway, a small garden, and a building with a sign indicating the number 8423.

5. 3 BR Condo near Reliant/NRG Stadium

3 BR Condo near Reliant/NRG Stadium
2.0 star property
South Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
United States
Jeffrey
The price is ₩153,368
₩501,475 total
includes taxes & fees
Oct 20 - Oct 21
3 BR Condo near Reliant/NRG Stadium
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

6. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (899 reviews)
"Amazing friendly staff."
United States
Olga
The price is ₩104,727
₩122,531 total
includes taxes & fees
Oct 22 - Oct 23
Candlewood Suites Houston Medical Center by IHG
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,002 reviews)
"Very clean, friendly staff and great breakfast."
United States
Elisa
The price is ₩152,928
₩180,014 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

8. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,705 reviews)
"Great stay!"
United States
Anthony
The price is ₩169,622
₩199,508 total
includes taxes & fees
Oct 26 - Oct 27
Hyatt Place Houston Medical Center
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

9. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,849 reviews)
"Excellent service and beautiful hotel"
United States
Jennifer
The price is ₩208,254
₩244,460 total
includes taxes & fees
Oct 25 - Oct 26
Blossom Hotel Houston, Curio Collection by Hilton
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

10. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,286 reviews)
"Great location and the bed was amazingly comfortable!!"
United States
Debra
The price is ₩169,622
₩199,508 total
includes taxes & fees
Nov 7 - Nov 8
Hyatt House Houston Medical Center
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

11. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
2.7 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel!"
United States
Jorge
The price is ₩137,756
₩162,842 total
includes taxes & fees
Oct 19 - Oct 20
Courtyard By Marriott Houston Medical Center Reliant Park
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

12. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.4 out of 10, Very good, (1,575 reviews)
"clean hotel, very nice I enjoyed my stay!"
United States
aundrea
The price is ₩94,477
₩117,250 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Ylem
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

13. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,197 reviews)
"Room was great, staff was helpful"
United States
Marvin
The price is ₩146,349
₩172,787 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Houston Plaza/Medical Center
A rooftop pool area with lounge chairs and a view of a tall building at night.

14. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,246 reviews)
"Great place"
United States
Matthew
The price is ₩215,697
₩268,479 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Houston Medical Center/Museum District
A spacious living area with a dining table, chairs, and a chandelier.

15. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,000 reviews)
"Great place!"
United States
Madiha
The price is ₩281,795
₩390,780 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Zaza Houston Museum District
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

16. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,332 reviews)
"Wonderful stay will stay again!"
United States
Brandon
The price is ₩193,342
₩226,210 total
includes taxes & fees
Oct 23 - Oct 24
The Royal Sonesta Houston Galleria
A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

17. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (463 reviews)
"Happy to stayed there!"
United States
AYTUNC
The price is ₩114,904
₩134,437 total
includes taxes & fees
Oct 18 - Oct 19
Best Western Plus Pearland/Houston Medical Center Hotel
A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

18. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.4 out of 10, Very good, (4,587 reviews)
"Wonderful-beautiful and clean hotel, excellent customer service-highly recommend"
United States
Nerissa
The price is ₩165,467
₩194,953 total
includes taxes & fees
Nov 5 - Nov 6
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
A hotel entrance with a sign reading "MORAN" and a neon sign for "radiom ilano".

19. The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
18.3 km from South Main
9.2 out of 10, Wonderful, (1,211 reviews)
"Great property and location"
United States
sophia
The price is ₩247,250
₩329,314 total
includes taxes & fees
Nov 14 - Nov 15
The Moran CITYCENTRE
A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

20. The Chifley Houston, Tapestry Collection by Hilton

The Chifley Houston, Tapestry Collection by Hilton
4.0 star property
The Galleria, 8.7 km from South Main
9.2 out of 10, Wonderful, (1,392 reviews)
"I always enjoy my stays here. The staff is consistently helpful and courteous, and the rooms are always clean and comfortable."
United States
Ashley
The price is ₩186,064
₩217,695 total
includes taxes & fees
Oct 30 - Oct 31
The Chifley Houston, Tapestry Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,003 reviews
View
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
899 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,456 reviews
View
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,000 reviews
View
A spacious lobby with a central seating area, a bar, and a reception desk.
Wingate Houston near Reliant Park/Medical Center
3.0 star property
6.6
1,006 reviews
View

Hotels recommended for families in South Main

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,003)
The price is ₩107,500
₩125,775 total
includes taxes & fees
Nov 4 - Nov 5
Comfort Suites Houston near Medical Center- NRG Stadium

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

10/10 Excellent
"Good place to stay at"
Carlos 1-night trip
Posted 2 hours ago
Wyndham Houston at Reliant Park & Medical Center

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to Reliant Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like Reliant Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.