What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page .

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Top South Main Hotels

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Our top choices for South Main hotels

A modern lobby with a blue carpet, seating area, and large windows.

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Timothy

₩151,449 total

includes taxes & fees

Sep 7 - Sep 8

A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

2. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

₩133,656 total

includes taxes & fees

Sep 14 - Sep 15

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

3. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

Linda

₩156,266 total

includes taxes & fees

Sep 8 - Sep 9

A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

4. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

₩111,530 total

includes taxes & fees

Sep 14 - Sep 15

A spacious lobby with a central seating area, a bar, and a reception desk.

5. Wingate Houston at Reliant Park & Medical Center

South Main

Terry

₩148,150 total

includes taxes & fees

Aug 30 - Aug 31

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

6. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Michael

₩202,517 total

includes taxes & fees

Sep 6 - Sep 7

A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

7. Hotel Ylem

2.3 km from South Main

Meryem

₩135,212 total

includes taxes & fees

Sep 5 - Sep 6

A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

8. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

₩171,489 total

includes taxes & fees

Sep 5 - Sep 6

A modern lobby with a bar area, seating arrangements, and a decorative fountain.

9. Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

Isabel

₩225,410 total

includes taxes & fees

Sep 6 - Sep 7

10. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Leland

₩204,517 total

includes taxes & fees

Sep 5 - Sep 6

A rooftop pool area with lounge chairs and a view of a tall building at night.

11. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Stanley

₩219,284 total

includes taxes & fees

Sep 4 - Sep 5

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

12. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

₩131,002 total

includes taxes & fees

Sep 6 - Sep 7

A person sitting on a white lounge chair with a striped towel, reading a book.

13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Lanita

₩107,892 total

includes taxes & fees

Sep 8 - Sep 9

A modern hotel lobby with a fireplace, seating area, and a decorative ceiling.

14. Homewood Suites by Hilton Houston Memorial

16.4 km from South Main

Roland

₩143,930 total

includes taxes & fees

Sep 6 - Sep 7

A hotel lobby with a hot tub, a pool, and a dining area.

15. Drury Inn & Suites Houston Near the Galleria

The Galleria, 9.4 km from South Main

Andrei

₩151,353 total

includes taxes & fees

Sep 6 - Sep 7

A multi-level atrium with a central water feature, glass railings, and outdoor seating areas.

16. Hyatt Regency Houston West

23.2 km from South Main

Tami

₩132,612 total

includes taxes & fees

Aug 30 - Aug 31

A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.

17. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 6.6 km from South Main

Raphael

₩128,514 total

includes taxes & fees

Sep 4 - Sep 5

A modern living room with a blue sofa set, patterned cushions, and a central wooden coffee table.

18. Sonesta ES Suites Houston Galleria

The Galleria, 8.4 km from South Main

Mikhail

₩170,570 total

includes taxes & fees

Sep 12 - Sep 13

A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

19. The Chifley Houston, Tapestry Collection by Hilton

The Galleria, 8.7 km from South Main

Emily

₩170,339 total

includes taxes & fees

Sep 5 - Sep 6

A hotel room with a sofa, ottoman, desk, and a bed.

20. Hyatt Place Houston/Galleria

8.7 km from South Main

Natasha

₩174,822 total

includes taxes & fees

Sep 2 - Sep 3

View all properties

Compare popular hotels in South Main

Property	Property class	Guest rating
Comfort Suites Houston near Medical Center- NRG Stadium	2.5 star property	8.8 Excellent 1,000 reviews	View
Wyndham Houston at Reliant Park & Medical Center	3.5 star property	7.2 Good 1,395 reviews	View
Candlewood Suites Houston Medical Center by IHG	2.5 star property	7.4 Good 896 reviews	View
Quality Inn & Suites NRG Park - Medical Center	2.5 star property	6.6 1,001 reviews	View
Wingate Houston at Reliant Park & Medical Center	3.0 star property	6.6 1,000 reviews	View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

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A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

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Top South Main Hotel Reviews

Club Quarters Hotel Downtown, Houston

10/10 Excellent

"Location was perfect for our one night stay. Walkable to Jones Hall and very convenient to food locations. We ate at table 7 bistro convenient and it was good. Room was clean and sufficient, carpets are aged and need updating but that aside everything else was fine."

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

10/10 Excellent

"Older Hotel with with charm. Not the cleanest communal space but the room was very clean. The hotel had excellent customer service. There is a 24 hour diner right by the hotel for overnight layovers like my stay which is very convenient. They also have a small store in the hotel and an excellent breakfast."

Find hotels in South Main, Houston

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

2. Candlewood Suites Houston Medical Center by IHG

3. Comfort Suites Houston near Medical Center- NRG Stadium

4. Quality Inn & Suites NRG Park - Medical Center

5. Wingate Houston at Reliant Park & Medical Center

6. Hyatt Place Houston Medical Center

7. Hotel Ylem

8. Courtyard By Marriott Houston Medical Center Reliant Park

9. Blossom Hotel Houston, Curio Collection by Hilton

10. Hyatt House Houston Medical Center

11. The Westin Houston Medical Center/Museum District

12. Hilton Houston Plaza/Medical Center

13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

14. Homewood Suites by Hilton Houston Memorial

15. Drury Inn & Suites Houston Near the Galleria

16. Hyatt Regency Houston West

17. DoubleTree by Hilton Hotel Houston - Greenway Plaza

18. Sonesta ES Suites Houston Galleria

19. The Chifley Houston, Tapestry Collection by Hilton

20. Hyatt Place Houston/Galleria

Compare popular hotels in South Main

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top South Main Hotel Reviews

Club Quarters Hotel Downtown, Houston

Frequently asked questions

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