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Aug 21 - Aug 23
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Aug 28 - Aug 30

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Our top choices for South Central Houston hotels

Outdoor pool

1. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (218 reviews)
"Beautiful place and wonderful management. Would definitely stay again! "
United States
Shelly
The price is ₩293,046
₩364,099 total
includes taxes & fees
Aug 19 - Aug 20
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Exterior detail

2. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (76 reviews)
"Amazing stay!!"
Canada
Elizabeth
The price is ₩225,093
₩304,767 total
includes taxes & fees
Aug 20 - Aug 21
Sentral Forme Houston
Exterior

3. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (593 reviews)
"I loved this property and the people who owned it are awesome!! Delicious breakfast, great location..clean and stylish rooms. Great amenitie!!!. Highly recommended!!"
United States
Charles
The price is ₩253,407
₩296,487 total
includes taxes & fees
Aug 18 - Aug 19
La Maison in Midtown an urban B&B
Reception

4. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1,004 reviews)
"This was my 4th stay at this property.. clean, comfortable, and great location.."
United States
Susanne
The price is ₩123,164
₩144,103 total
includes taxes & fees
Aug 18 - Aug 19
Americas Best Value Inn Medical Center Downtown
Laptop workspace, blackout drapes, soundproofing

5. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (227 reviews)
"The hot tub was fantastic"
United States
Erica
The price is ₩135,905
₩159,009 total
includes taxes & fees
Aug 18 - Aug 19
Downtowner Inns - Houston Downtown
Lobby

6. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (969 reviews)
"Pretty amazing stay"
United States
DELISA
The price is ₩219,402
₩256,701 total
includes taxes & fees
Aug 23 - Aug 24
Hilton University of Houston
Dinner served

7. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,002 reviews)
"I enjoyed my stay!"
United States
Valencia
The price is ₩191,329
₩268,742 total
includes taxes & fees
Aug 21 - Aug 22
Houston Marriott Medical Center/Museum District
Presidential Suite, 1 Twin Bed | In-room dining

8. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,006 reviews)
"Great bar staff and food"
United States
Eric
The price is ₩227,924
₩294,985 total
includes taxes & fees
Aug 29 - Aug 30
InterContinental Houston by IHG
Premium bedding, pillowtop beds, minibar, in-room safe

9. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,007 reviews)
"Clean, reasonably priced, accommodating, helpful staff, great location."
United States
Sarah
The price is ₩327,886
₩439,555 total
includes taxes & fees
Aug 18 - Aug 19
Hotel Zaza Houston Museum District
Outdoor pool, free cabanas, pool umbrellas

10. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,184 reviews)
"Loved the location and hospitality of the staff. Enjoyed the restaurant in the hotel."
United States
Stanley
The price is ₩203,362
₩253,123 total
includes taxes & fees
Sep 6 - Sep 7
The Westin Houston Medical Center/Museum District
Breakfast, lunch and dinner served

11. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (660 reviews)
"Very clean room, the staff very nice, professional and friendly, breakfast was good, shuttle available to MD Anderson"
United States
Alma
The price is ₩172,968
₩202,372 total
includes taxes & fees
Aug 21 - Aug 22
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Iron/ironing board (on request), bed sheets

12. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very Good, (47 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is ₩84,941
₩106,459 total
includes taxes & fees
Aug 23 - Aug 24
Scott Inn Suites - Downtown Houston
House | 3 bedrooms

13. Modern 3BR Near UH Downtown Toyota Center NRG

Modern 3BR Near UH Downtown Toyota Center NRG
2.0 star property
South Central Houston
The price is ₩163,457
₩970,392 total
includes taxes & fees
Aug 18 - Aug 19
Modern 3BR Near UH Downtown Toyota Center NRG
Reception

14. Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (4 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ₩92,019
₩113,183 total
includes taxes & fees
Aug 31 - Sep 1
Golden Motel Near Houston Medical Center
Lobby

15. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.0 out of 10, (1,003 reviews)
"The room was very clean, comfortable beds..the sleeper sofas could use a better mattress and cleaner linens but they will give you some if you ask for them. The staff is very friendly the property is clean over all we like staying here every time we come for appointments since it is close to all the hospitals"
United States
Ysela
The price is ₩100,641
₩118,167 total
includes taxes & fees
Aug 20 - Aug 21
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Terrace/patio

16. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (2,105 reviews)
"Brilliant location and pool"
United Kingdom
Daniel
The price is ₩116,199
₩137,596 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Houston Plaza/Medical Center
Standard Room, 1 King Bed | 1 bedroom, premium bedding, blackout drapes, WiFi (free)

17. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (244 reviews)
"I was pleasantly surprised by how well kept the room was and the staff was very friendly"
United States
Brian
The price is ₩84,908
₩99,341 total
includes taxes & fees
Aug 18 - Aug 19
Southmore Boulevard Motel
Interior

18. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very Good, (212 reviews)
"Excellent stay experience"
United States
Binkeung
The price is ₩87,914
₩102,864 total
includes taxes & fees
Aug 19 - Aug 20
Wanderstay Houston Hostel
House | 1 bedroom

19. Affordable Eado Stay Near Downtown Houston

Affordable Eado Stay Near Downtown Houston
2.0 star property
South Central Houston
The price is ₩99,461
₩508,290 total
includes taxes & fees
Aug 18 - Aug 19
Affordable Eado Stay Near Downtown Houston
House | 2 bedrooms

20. 2-bedroom - Equipped Kitchen - Gated Parking

2-bedroom - Equipped Kitchen - Gated Parking
2.0 star property
South Central Houston
The price is ₩99,158
₩853,979 total
includes taxes & fees
Sep 9 - Sep 10
2-bedroom - Equipped Kitchen - Gated Parking
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
593 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
218 reviews
View
Laptop workspace, blackout drapes, soundproofing
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
227 reviews
View
Exterior
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,006 reviews
View
Outdoor pool, free cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,184 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

Top South Central Houston Hotel Reviews

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

10/10 Excellent
"Very clean and located close to Rice university"
Kristen 2-night trip
Posted 7 hours ago
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Fertitta Center as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1252 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Twilight Epiphany Skyspace. TDECU Stadium and Fertitta Center are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.