Find hotels in South Central Houston, Houston

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Our top choices for South Central Houston hotels

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (505 reviews)
"Room accommodations for disability, clean, comfortable beds and bedding, and having a resturant on site. Thank you for a great stay!"
United States
Judy
The price is ₩126,544
₩148,057 total
includes taxes & fees
Feb 1 - Feb 2
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,891 reviews)
"An amzing stay, great staff and overal luxery feeling"
United Kingdom
Wendy
The price is ₩569,157
₩738,656 total
includes taxes & fees
Feb 2 - Feb 3
Hotel Zaza Houston Museum District

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (1,836 reviews)
"Amazing room, great rate! "
United States
Sherri
The price is ₩132,174
₩156,327 total
includes taxes & fees
Feb 1 - Feb 2
Hilton Houston Plaza/Medical Center

Rodeway Inn & Suites Houston near Medical Center

Rodeway Inn & Suites Houston near Medical Center
2.0 star property
South Central Houston
6.0 out of 10, (498 reviews)
"Very economical. Great price for one night stay."
United States
AUGUSTIN
The price is ₩84,880
₩99,308 total
includes taxes & fees
Jan 28 - Jan 29
Rodeway Inn & Suites Houston near Medical Center

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (61 reviews)
"Perfect space for my overnight stay but I had dreams of renting the full space for a family event in the future. "
United States
Marva
The price is ₩172,401
₩201,730 total
includes taxes & fees
Feb 1 - Feb 2
Wanderstay Boutique Hotel

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (547 reviews)
"Good rooms and location, great staff!"
United States
Eugene
The price is ₩259,763
₩303,922 total
includes taxes & fees
Jan 29 - Jan 30
La Maison in Midtown an urban B&B

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,003 reviews)
"Very courteous staff"
United States
Jolynn
The price is ₩245,469
₩334,120 total
includes taxes & fees
Feb 6 - Feb 7
Houston Marriott Medical Center/Museum District

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,007 reviews)
"Very clean room & responsive staff!"
United States
ERIC
The price is ₩233,642
₩302,385 total
includes taxes & fees
Feb 1 - Feb 2
InterContinental Houston by IHG

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (202 reviews)
"I absolutely loved my stay here!!"
United States
Daniella
The price is ₩300,396
₩373,231 total
includes taxes & fees
Jan 29 - Jan 30
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,077 reviews)
"Great place to stay "
United States
Ernest
The price is ₩209,820
₩261,164 total
includes taxes & fees
Feb 1 - Feb 2
The Westin Houston Medical Center/Museum District

The Oasis Checkmate HTX Rooftop

The Oasis Checkmate HTX Rooftop
3.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"This place is amazing! Beautiful decor and location is perfect for any event near the convention center. Safe and secure. Hosts were responsive and friendly. I let them know the ironing board was missing and they had a new one sent from Amazon the next day! 10/10 recommend and will rebook. "
United States
Veronica
The price is ₩403,073
₩994,206 total
includes taxes & fees
Jan 29 - Jan 30
The Oasis Checkmate HTX Rooftop

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1,004 reviews)
"Nice hotel"
United States
Robert Jeanmard
The price is ₩102,381
₩119,781 total
includes taxes & fees
Jan 28 - Jan 29
Americas Best Value Inn Medical Center Downtown

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (891 reviews)
"Nice place to stay"
United States
Alexandra
The price is ₩216,663
₩253,496 total
includes taxes & fees
Feb 15 - Feb 16
Hilton University of Houston

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (229 reviews)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is ₩97,955
₩114,615 total
includes taxes & fees
Jan 28 - Jan 29
Southmore Boulevard Motel

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
7.8 out of 10, Good, (50 reviews)
"Staff was helpful"
United States
Jonathan
The price is ₩124,077
₩145,177 total
includes taxes & fees
Jan 29 - Jan 30
Downtowner Inns - Houston Downtown

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very Good, (190 reviews)
"This is an amazing place to stay."
United States
Darius
The price is ₩80,048
₩93,646 total
includes taxes & fees
Jan 29 - Jan 30
Wanderstay Houston Hostel

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,019 reviews)
"Clean"
United States
William
The price is ₩95,329
₩111,974 total
includes taxes & fees
Feb 1 - Feb 2
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is ₩344,716
₩996,475 total
includes taxes & fees
Jan 30 - Jan 31
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
The price is ₩171,490
₩549,050 total
includes taxes & fees
Feb 1 - Feb 2
Newly Built Modern 3 Bedroom Houston Home

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1 review)
The price is ₩382,768
₩974,788 total
includes taxes & fees
Feb 24 - Feb 25
The Green Haus Luxxe Cabana Rooftop Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out Children's Museum of Houston and Houston Natural Science Museum as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 4-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other favorite options in the area include Wanderstay Boutique Hotel and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1161 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, James Turrell's Twilight Epiphany Skyscape, and Cullen Sculpture Garden. Children's Museum of Houston and Houston Natural Science Museum are some other stops to visit in the neighborhood. Daikin Park, Shape Community Center, and Project Row Houses are just a few of the places to visit in and around South Central Houston. H&PE Arena and Eldorado Ballroom are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.