South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and entertainment choices in this vibrant area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed art scene and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the great live music and acclaimed theater scene in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
South Main Hotel Deals
Hotel Zaza Houston Museum District
"Overall great hotel. Definitely will be staying here again. Shout out to the staff crew."
Reviewed on May 30, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
"A1"
Reviewed on Jun 1, 2026
Club Quarters Hotel Downtown, Houston
"Staff was very friendly and helpful."
Reviewed on Jun 1, 2026
Blossom Hotel Houston, Curio Collection by Hilton
"Jekdnrbrnrbr"
Reviewed on May 31, 2026
Grand Tuscany Hotel
"What I liked about my stay was peace of mind & security with leaving my belongings on site. The paid parking made me feel better about the safety of my car. Upkeep on furniture & fixtures could have been better, but nothing that would stop me from staying in the future."
Reviewed on Jun 1, 2026
The Whitehall Houston
"This property is extremely outdated and in need of significant updates. The staff was unfriendly and unhelpful throughout my stay. The breakfast was disappointing and far below expectations. Overall, it seems like this place has not been properly inspected or maintained in quite some time."
Reviewed on Jun 1, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Houston Zoo and Children's Museum of Houston, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Houston Zoo or Fertitta Center and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Fertitta Center or Barbara Jordan & Mickey Leland Archives, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
