Otay Mesa, CA

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area, or simply enjoy its restaurants.
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Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
The price is ₩189,282 per night from Sep 24 to Sep 25
₩189,282
₩215,309 total
Sep 24 - Sep 25
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,863 reviews)
"Good hotel for the area, can’t go wrong with a holiday inn express."

Reviewed on Aug 24, 2026

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is ₩297,325 per night from Sep 7 to Sep 8
₩297,325
₩414,873 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is ₩268,034 per night from Sep 8 to Sep 9
₩268,034
₩386,056 total
Sep 8 - Sep 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,845 reviews)
"Great time and excellent breakfast!"

Reviewed on Aug 25, 2026

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is ₩210,213 per night from Aug 27 to Aug 28
₩210,213
₩291,811 total
Aug 27 - Aug 28
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩233,701 per night from Aug 30 to Aug 31
₩233,701
₩308,336 total
Aug 30 - Aug 31
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,462 reviews)
"This trip was meant a lot to me and my family. We didn’t come for a vacation but to honor and celebrate my husband who passed away. Our great experience at the created a space for our family to share, celebrate, and heal. Thank you to the staff for the clean room and hospitality."

Reviewed on Aug 25, 2026

The Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is ₩245,403 per night from Aug 26 to Aug 27
₩245,403
₩351,419 total
Aug 26 - Aug 27
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,279 reviews)
"Perfect"

Reviewed on Aug 25, 2026

Hard Rock Hotel San Diego
See all 4,957 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Otay Mesa, CA