Otay Mesa West, CA

San Diego

A marina with boats docked, a city skyline with high-rise buildings, and a sunset with pink and orange clouds.

Otay Mesa West Hotel Deals

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is ₩271,958 per night from Oct 25 to Oct 26
₩271,958
₩384,850 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
The price is ₩114,658 per night from Sep 29 to Sep 30
₩114,658
₩131,793 total
Sep 29 - Sep 30
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Best Western Seven Seas
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is ₩207,723 per night from Sep 27 to Sep 28
₩207,723
₩288,355 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,314 reviews)
"Room was very dated. Entire hotel in need of updating. Very surprising for such a great location in San Diego. Bathroom was lacking in amenities and decor. Dark and poor lighting. Terrible bathtub and faucet. It was clean enough. I messaged and called ahead to get an early check in time and was told ..."

Reviewed on Sep 24, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundable
The price is ₩139,867 per night from Sep 28 to Sep 29
₩139,867
₩160,771 total
Sep 28 - Sep 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,946 reviews)
"Maintained well."

Reviewed on Sep 23, 2026

Handlery Hotel
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
The price is ₩120,757 per night from Sep 27 to Sep 28
₩120,757
₩138,566 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,981 reviews)
"Only thing I had neighbor a lady with 2 kids were banging wall and being annoyed never happened to me before first time but it’s good place to stay I like it alot that were I stay always"

Reviewed on Sep 24, 2026

California Suites Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is ₩326,295 per night from Sep 27 to Sep 28
₩326,295
₩452,717 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,868 reviews)
"We had a lovely stay. Walking distance to seaport which is a must see everytime we visit. the staff were so nice and helpful. The view was amazing and we will definitely stay again."

Reviewed on Sep 23, 2026

Manchester Grand Hyatt San Diego
See all 7,033 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A pier at sunset with people sitting and standing, waves crashing below.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Lyceum Theatre or Gaslamp Museum at the Davis-Horton House is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Otay Mesa West, CA