Otay Mesa West, CA

San Diego

Photo by Leonardo De Leon
Photo by Leonardo De Leon
Photo by Leonardo De Leon
Photo by Leonardo De Leon

Popular places to visit

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park
Mission Beach featuring tropical scenes, street scenes and a beach

Mission Beach

A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.

Mission Beach
Bayside Skyride at Sea World, San Diego, CA

SeaWorld

Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.

SeaWorld

Otay Mesa West Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
The price is ₩162,520 per night from Jul 28 to Jul 29
₩162,520
₩186,808 total
Jul 28 - Jul 29
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,891 reviews)
Birthday Celebration
"Check in was easy, Hotel is older but fairly well maintained, The Staff was friendly and helpful, at the front desk during check in one of the staff team (WHO WAS NOT HELPING US AT ALL) went into a back office and came out a few minutes later with a ballon saying "where is that little guy" That simple ..."

Reviewed on Jul 21, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is ₩198,335 per night from Jul 27 to Jul 28
₩198,335
₩269,606 total
Jul 27 - Jul 28
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,770 reviews)
"we really liked the property but wish when we checked in they did a better job of explaining food options near or at the hotel . we spent a lot of time looking n it’s all very expensive so some tips would have been ideal"

Reviewed on Jul 22, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is ₩272,132 per night from Jul 28 to Jul 29
₩272,132
₩390,102 total
Jul 28 - Jul 29
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,789 reviews)
"Enjoyed my stay at this place. Friendly and courteous staff"

Reviewed on Jul 21, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is ₩247,279 per night from Aug 10 to Aug 11
₩247,279
₩284,234 total
Aug 10 - Aug 11
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,582 reviews)
Perfect Staycation Hotel
"This is our 4th time staying at the Dana and we love it! Such beautiful views and even tho a bit pricey, my kids love it has 2 pools with 2 spas and movie nights! The staff are great and it’s very quiet and home feeling . We will be back in a couple of months !"

Reviewed on Jul 22, 2025

The Dana on Mission Bay
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
The price is ₩321,836 per night from Jul 28 to Jul 29
₩321,836
₩434,780 total
Jul 28 - Jul 29
includes taxes & fees
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,770 reviews)
"Great hotel, everything nice"

Reviewed on Jul 19, 2025

Marriott Marquis San Diego Marina
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is ₩168,001 per night from Jul 30 to Jul 31
₩168,001
₩194,462 total
Jul 30 - Jul 31
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.6/10 Good! (1,032 reviews)
"Parking was confusing and the staff was knowledgeable about the area. The room is OK and the location was great. I had asked for my room to be cleaned twice and they were only doing it one time but it wasn’t a dealbreaker. I’d stay here again because now I know the lay of the land"

Reviewed on Jul 22, 2025

The Dextro Hotel, BW Premier Collection
See all 6,555 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Otay Mesa West

Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Gaslamp Quarter
US Grant Hotel

Downtown San Diego

4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Downtown San Diego
Little Italy

Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
Lake Murray in San Diego

Mid-City

If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Loads of Loafs

Hillcrest

3.5/5(53 area reviews)

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest
Sunset Cliffs Natural Park featuring general coastal views, a coastal town and rocky coastline

Point Loma

3.5/5(3,808 area reviews)

This seaside hilly peninsula offers marine recreation, yachting, and whale watching. Explore Cabrillo National Monument, Old Point Loma Lighthouse, and Sunset Cliffs Natural Park. Enjoy local shops and eateries at Liberty Station and Point Loma Village.

Point Loma

Otay Mesa West, CA