Top Otay Mesa Hotels

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

See properties

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

See properties

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

See properties

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

See properties

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

See properties

Top Otay Mesa Hotel Reviews

Days Inn by Wyndham San Diego Hotel Circle

4/10 Poor

"The bathtub had a bug crawling around in it. There was hair in the sink and on the floor. The hot tub was broken. They charged $20 a night for parking. I went back and looked at the listing on hotels.com and it was never mentioned that they charged for parking. They put 2 different $100 holds on my credit card for one room. The line to check in was very long. Rooms were old and outdated. Probably would not stay here again."

The Sofia Hotel

6/10 Okay

"Although clean, the room was the smallest we’ve ever stayed in, to the point that the sink was in the room not the bathroom. Very nice rain shower, but water didn’t drain properly the first day - it was fixed after notifying the front desk. View out the window was a wall several feet away. Air conditioning unit was loud and rattled all night, and the bed was hard and uncomfortable. Parking was $50 per night, but that appeared to be par for the downtown area."

Best Western Seven Seas

6/10 Okay

"Its San Diego… so not like uts going to be a great deal, but it was reasonably priced. The parking lot was being renovated so it wasn’t great access but still worked. Restaurants there (didn’t eat there though) and it obviously wasn’t the Waldorf but it worked. I did see a bunch of people using the Hot Tub so I’m gonna assume that it worked. All in all and adequate choice for the money."

Wyndham San Diego Bayside

8/10 Good

"Check in took a little longer than expected as there was only one front desk clerk and a really long line. It wasn’t her fault as I heard her mention she asked for help but the manager brushed her off. The room was small but worked for us. The view of the bay was amazing and it was so neat"

The Alcala Hotel Mission Valley/Seaworld

6/10 Okay

"The description of the bed on the website site was queen bed but the actual size was a full bed. The gym is almost not usable. There is no game room as described on the website. The toiletries was insufficient . The aircon in our room was so noisy everytime it runs on and I was not able to sleep because of the loud noise it was producing every few minutes .The place could use a little bit more cleaning and fixing up. The staff were great though and the breakfast was good. The price we got was good but you really get what you pay for."

Bahia Resort Hotel

10/10 Excellent

"I loved my time there! It was a solo trip and I felt safe. My room was clean and the staff was beyond courteous and helpful. Awesome, drinks, dinner, and sunset! I want to being my family there and have the experience of the bay outside our doors and the ocean within walking distance. Thank you for everything."

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia

Flights to San Diego Intl.

Book Hotels in Otay Mesa on Expedia.com

Find hotels in Otay Mesa, San Diego

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Lafayette Hotel & Club

Sycuan Casino Resort

Best Western Chula Vista/Otay Valley Hotel

Valli Hi Motel

Best Western San Diego Pacific Beach/Mission Bay

The Alcala Hotel Mission Valley/Seaworld

Wyndham Garden San Diego Near SeaWorld

Hampton Inn & Suites San Diego Airport Liberty Station

La Quinta Inn by Wyndham San Diego Chula Vista

Days Inn by Wyndham San Diego-East/El Cajon

Courtyard by Marriott San Diego Airport/Liberty Station

Ocean Villa Inn

Best Western Americana Inn

Wyndham San Diego Bayside

Best Western Plus Marina Gateway Hotel

Holiday Inn Express San Diego Airport - Old Town by IHG

Where to stay in Otay Mesa

Downtown San Diego

Pacific Beach

Mission Beach

Gaslamp Quarter

Mission Bay

Top Otay Mesa Hotel Reviews

Days Inn by Wyndham San Diego Hotel Circle

Frequently asked questions

Explore a world of travel with Expedia