Find hotels in Santa Ana, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (63 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (58 reviews)
"Excelente "
Mexico
David
The price is ₩37,395
₩41,140 total
includes taxes & fees
Jan 22 - Jan 23
Hostal La Cigarra

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182 reviews)
"Super outdated. Looks dangerous in the area"
United States
Nina Kristine
Hotel República

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ₩96,880
₩147,119 total
includes taxes & fees
Jan 22 - Jan 23
La Manzana by Wynwood House

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (189 reviews)
"It was a great stay in a great neighborhood with many food and beverage options, fantastic hosts and an interesting mix of people "
Canada
Brad
The price is ₩60,915
₩67,006 total
includes taxes & fees
Jan 31 - Feb 1
Panama House Bed & Breakfast

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 2.7 km from Santa Ana
6.0 out of 10, (403 reviews)
"The hotel was as I expected. Nothing fancy but clean, comfortable, with easy access from the city. There was parking always available. The restaurant, bar, and the pool were open. The people who worked there had the best predisposition to help and make our time in the hotel great. "
United States
Maria Eugenia Fourcade
Hotel Montreal

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1,003 reviews)
"The room, staff and food were all amazing ! Felt comfortable. "
United States
Shirley
The price is ₩126,961
₩139,657 total
includes taxes & fees
Jan 27 - Jan 28
Hilton Garden Inn Panama City Downtown, Panama

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (277 reviews)
"Good room - clean and quiet, Hotel location is on a commercial street with many restaurants and bars nearby and within walking distance to a metro station. "
Canada
P
The price is ₩106,538
₩117,192 total
includes taxes & fees
Jan 22 - Jan 23
Ramada Panama Centro Via Argentina

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.2 out of 10, Very Good, (215 reviews)
"Staff were amazing . Great breakfast and convenient area close to the train station "
United States
Darius
The price is ₩129,763
₩142,739 total
includes taxes & fees
Feb 1 - Feb 2
Crowne Plaza Panama by IHG

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (728 reviews)
"Very comfortable, clean, located in El Cangrejo, a lively area. Breakfast was good and saved us time for our coming trip."
United States
Alberto
Toscana Inn

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (278 reviews)
"Staff was amazing!! Room was great as well!! "
United States
John
Tantalo Hotel

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 1.3 km from Santa Ana
7.8 out of 10, Good, (130 reviews)
"Excelente"
United States
Alejandro
The price is ₩44,200
₩48,620 total
includes taxes & fees
Feb 2 - Feb 3
Hotel Acapulco

Hotel y Casino Central Park Panama

Hotel y Casino Central Park Panama
3.0 star property
Bethania, 5.6 km from Santa Ana
7.6 out of 10, Good, (430 reviews)
"Great service, clean, great location "
United States
EDGAR
The price is ₩95,552
₩105,107 total
includes taxes & fees
Jan 22 - Jan 23
Hotel y Casino Central Park Panama

Hotel Vía España

Hotel Vía España
3.0 star property
Calidonia, 2.4 km from Santa Ana
6.2 out of 10, (174 reviews)
"Don’t stay there it’s the "
United States
Andreas
Hotel Vía España

Hotel Latino

Hotel Latino
3.0 star property
Calidonia, 1.8 km from Santa Ana
6.6 out of 10, (223 reviews)
"Fair for the price. Restaurant is great"
United States
Gleisther
Hotel Latino

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 1.8 km from Santa Ana
7.8 out of 10, Good, (114 reviews)
"Great spot for the price "
United States
frank
Hotel Pension Corona

Metro Hotel Panama

Metro Hotel Panama
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
7.8 out of 10, Good, (407 reviews)
"This is a a convenient hotel, located in a prime area in the city. The staff is friendly, helpful and the room is cleaned every day. "
United States
Warren
Metro Hotel Panama

Villa Caprichosa

Villa Caprichosa
3.0 star property
18.3 km from Santa Ana
9.8 out of 10, Exceptional, (45 reviews)
"Would definitely visit again "
United States
John
The price is ₩368,645
₩405,510 total
includes taxes & fees
Jan 23 - Jan 24
Villa Caprichosa

Hotel Marparaiso

Hotel Marparaiso
3.0 star property
Calidonia, 1.7 km from Santa Ana
8.0 out of 10, Very Good, (162 reviews)
"I love the hotel and ever thing about it ,location transport, safe around the hotle ."
United States
Andres
The price is ₩58,983
₩64,881 total
includes taxes & fees
Jan 22 - Jan 23
Hotel Marparaiso

Explora San Blas

Explora San Blas
2.0 star property
San Felipe, 0.8 km from Santa Ana
10.0 out of 10, Exceptional, (2 reviews)
"San Blas is a unique experience, and Explora was the best place to be. Juan helped us tremendously after booking and until the end. Bring sunscreen and some games with you. A guitar if u can play. Get ready to make friends and memories!"
United States
Anonymous traveler
Explora San Blas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or Museum of History Panama while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and Museum of History Panama are top sights worth seeing.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 108 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.