Panama City Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for Panama City vacation rentals

Superior Double Room | Terrace/patio
La Isabela Suites

La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (171)
"Wonderful charming property in the heart of the historic district. "
United States
Angela
La Isabela Suites
Studio, 1 King Bed, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated
Las Clementinas

Las Clementinas

Las Clementinas
3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (171)
"The front desk receptionist was extremely helpful! The room was clean and comfortable! We would definitely stay again!"
United States
april
The price is ₩219,795
₩241,780 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Las Clementinas
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (175)
"Was a great buy. Beautiful views and spacious rooms. Great amenities. "
United States
Lesley
The price is ₩119,369
₩197,911 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Arcadia Condo Suites
Microwave, coffee/tea maker, cookware/dishes/utensils
La Palma Aparta Suite

La Palma Aparta Suite

La Palma Aparta Suite
3.0 star property
Amador
The price is ₩68,335
₩118,418 total
includes taxes & fees
Dec 31 - Jan 1, 2026
La Palma Aparta Suite
Apartment (CC4B) | Balcony
Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House
4.0 star property
Casco Viejo
8.2 out of 10, Very Good, (20)
"Great place!"
United States
Jad
The price is ₩220,574
₩278,673 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Casa Contemporanea by Wynwood House
Standard Apartment | Living area | Flat-screen TV
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (485)
"Room was clean, neat great staff"
United States
Alfredo
Torres de Alba Hotel & Suites
Apartment | Exterior
Centriqo by Wynwood house

Centriqo by Wynwood house

Centriqo by Wynwood house
3.0 star property
Veracruz
The price is ₩184,244
₩250,243 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Centriqo by Wynwood house
Apartment (14D) | Private kitchen
Mini Design By Wynwood House

Mini Design By Wynwood House

Mini Design By Wynwood House
2.0 star property
Bella Vista
The price is ₩175,162
₩232,324 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Mini Design By Wynwood House
Outdoor pool
Studio Apartment with Ocean View

Studio Apartment with Ocean View

Studio Apartment with Ocean View
3.0 star property
Calidonia
8.0 out of 10, Very Good, (2)
"It was similar to a hotel room, but a little smaller.. the bed is big enough for just one person and check in was the most difficult thing he had to wait outside in the rain and download apps"
United States
Gwendolyn
The price is ₩93,708
₩103,079 total
includes taxes & fees
Jan 27 - Jan 28, 2026
Studio Apartment with Ocean View
Outdoor pool, free cabanas, sun loungers
Yoo Panama & Arts Tower

Yoo Panama & Arts Tower

Yoo Panama & Arts Tower
3.0 star property
Bella Vista
9.6 out of 10, Exceptional, (56)
"Ron was amazing and so was the property!"
United States
John
Yoo Panama & Arts Tower
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is ₩237,240
₩481,394 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Wanders Panama by Boutique Apartments
Apartment, 1 Bedroom, Balcony | Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is ₩110,309
₩138,311 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Swette Love 10 Minutes From the Airport Tocumen
Apartment, 2 Bedrooms (2C) | Iron/ironing board, free WiFi, bed sheets
Donovan By Wynwood House

Donovan By Wynwood House

Donovan By Wynwood House
3.0 star property
Casco Viejo
8.4 out of 10, Very Good, (45)
"I always love to stay at Wynwood properties in Panama "
United States
Alberto B
The price is ₩135,516
₩192,318 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Donovan By Wynwood House
Outdoor pool
Yoo by Wynwood House

Yoo by Wynwood House

Yoo by Wynwood House
4.0 star property
Calidonia
9.2 out of 10, Wonderful, (5)
"I will be back!"
United States
Jeffrey
The price is ₩313,994
₩396,139 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Yoo by Wynwood House
Outdoor pool
Boutique Apartments Panama

Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (222)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Panama City Hotel Reviews

Principe Hotel and Suites

Principe Hotel and Suites

10/10 Excellent
"Excellent!"
Salvador 1-night trip
Posted 16 hours ago
Principe Hotel and Suites

Find out more about Panama City

Search for Vacation rentals in Panama City on Expedia.co.uk! You can easily find your home rentals, villas, Vacation apartments in Panama City using one of the methods below:

  • View our selection of featured Vacation rentals in Panama City
  • Use the map to find apartments and other Vacation homes in the Panama City neighbourhood you prefer
  • Enter your travel dates to view the best deals on Vacation rentals in Panama City while they last

Look no further and take a look at our great range of rental properties in Panama City!

Frequently asked questions

Can I find vacation rentals in Panama City?

Yes, we give you a choice of vacation rentals in Panama City near Panama Canal Railway, or you can choose a more remote option if you're looking for a relaxing stay. Tourists like the array of shops and top-notch restaurants in Panama City. While you're in the area, grab a bite or have a drink at the lively bars and cafes.

How many vacation rentals are there in Panama City?

With 56 Expedia vacation rentals, you're sure to find just the right place for your Panama City stay.

What can I see and do in Panama City?

Cultural attractions include National Theater and Interoceanic Canal Museum, whereas Cinta Costera and Miraflores Locks are a couple of picturesque spots to enjoy the outdoors. Albrook Shopping Mall and Via Espana are other places to visit while you're in town.

What are vacation rentals like in Panama City?

Vacation rentals are privately owned accommodations you can stay in for several days or longer in Panama City. Vacation rentals offer amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about cleanliness, vacation rentals can provide a sense of safety away from public hotel elevators and busy lobbies while still allowing you to travel. You'll also find more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for families.