Find Resorts & Hotels with Spas in Panama City

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Panama City Resorts & Hotels with Spas

Our top choices for Panama City hotels with a spa

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1852)
"Clean room and friendly staff "
United States
Delcides
The price is ₩184,789
₩203,268 total
includes taxes & fees
Dec 14 - Dec 15
Riande Aeropuerto Hotel & Casino

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2129)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is ₩159,519
₩175,471 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Plaza Paitilla Inn Hotel

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (556)
"Great hotel and location "
United Kingdom
Russell
The price is ₩550,136
₩605,150 total
includes taxes & fees
Dec 15 - Dec 16
Sofitel Legend Casco Viejo, Panama City

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1005)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ₩382,727
₩421,000 total
includes taxes & fees
Dec 14 - Dec 15
JW Marriott Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1002)
"I loved everything about my stay "
United States
Stephanie
The price is ₩325,953
₩358,548 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Waldorf Astoria Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1002)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is ₩293,111
₩322,422 total
includes taxes & fees
Dec 18 - Dec 19
The Westin Playa Bonita Panama

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very Good, (1267)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is ₩204,652
₩225,117 total
includes taxes & fees
Dec 21 - Dec 22
Megapolis Hotel Panamá

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (990)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ₩198,161
₩217,977 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sheraton Grand Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (638)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₩341,349
₩375,484 total
includes taxes & fees
Dec 21 - Dec 22
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is ₩475,823
₩523,405 total
includes taxes & fees
Dec 23 - Dec 24
Hotel La Compañía Casco Antiguo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Spa hotels with pools in Panama City

Spa hotels with hot tubs in Panama City

Spa hotels with free breakfast in Panama City

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Panama City

Top Panama City attractions for a relaxing vacation

In Panama City, travelers seeking luxurious spa hotels will find a wealth of experiences that cater to relaxation and rejuvenation. Start your journey at the Amador Causeway, where scenic views of the Pacific Ocean and the stunning skyline create a picturesque backdrop for leisurely strolls or bike rides. Nearby, the Biomuseo offers an engaging dive into Panama’s biodiversity and history, allowing for a cultural touch to your stay. For those who enjoy nature, the Metropolitan Natural Park provides a lush escape with walking trails that lead to panoramic views of the city, perfect for unwinding amidst greenery. After a day of exploration, indulge in a spa treatment at one of the city's upscale hotels, such as the Waldorf Astoria Panama, known for its luxurious amenities and exceptional service. The Casco Viejo district, with its charming cobblestone streets and vibrant nightlife, offers a unique blend of history and modernity, making it an exciting area to explore while staying at a boutique hotel that prioritizes guest satisfaction. Each of these experiences ensures a perfect balance of adventure and pampering, allowing for a memorable stay in Panama City.

Find the best hotels & resorts with spas in Panama City

For travelers seeking rejuvenation and relaxation in Panama City, these top hotels offer exceptional spa amenities and tranquil environments for a perfect getaway.

Ramada Plaza By Wyndham Panama Punta Pacífica

  • Why it's great for tailored spa getaway: Ramada Plaza By Wyndham Panama Punta Pacífica is a haven for spa enthusiasts, featuring a dedicated treatment room and a fantastic review rating of 9.6. Guests can unwind in the outdoor pool or indulge in the hotel’s delicious dining options, ensuring a well-rounded experience that focuses on relaxation and enjoyment.
  • Other amenities: In addition to its spa amenities, this hotel provides a complimentary buffet breakfast and features like a 24-hour fitness center, concierge service, and a shopping mall on-site. The hotel’s romantic ambiance and thoughtful touches, like champagne service, make it a wonderful choice for those looking to combine relaxation with a touch of luxury.
  • Neighborhood: San Francisco
  • Nearby attractions: ATLAPA Conventions Center - 0.64 miles, Calle 50 - 0.41 miles, Multiplaza Pacific Mall - 0.21 miles

Plaza Paitilla Inn Hotel

  • Why it's great for tailored spa getaway: Travelers looking for a spa retreat will find Plaza Paitilla Inn Hotel an excellent option, highlighted by a remarkable review rating of 9.4. The hotel offers a range of spa services, including Swedish and hot stone massages, alongside rejuvenating body treatments. The inviting outdoor pool area is perfect for unwinding after a day of pampering.
  • Other amenities: Beyond its spa offerings, guests can enjoy a complimentary buffet breakfast each morning and benefit from amenities such as a fitness center, terrace for relaxation, and convenient on-site shopping. The hotel’s location also provides easy access to the vibrant Punta Paitilla area, enhancing the overall travel experience.
  • Neighborhood: Punta Paitilla
  • Nearby attractions: Avenida Balboa - 0.33 miles, Cinta Costera - 0.48 miles, Multicentro Panama - 0.85 miles

Bristol Panama, a Registry Collection Hotel

  • Why it's great for tailored spa getaway: For travelers seeking an exceptional spa experience, Bristol Panama stands out with an impressive review rating of 9.2. The hotel features a full-service spa offering a diverse range of treatments, including Swedish and prenatal massages, ensuring guests can experience the ultimate in relaxation and rejuvenation. The serene atmosphere of the spa is complemented by an outdoor pool for leisurely afternoons.
  • Other amenities: Guests can also enjoy amenities such as an on-site art gallery, complimentary airport transportation, and a well-equipped fitness center. Additional features include luxurious in-room amenities like Egyptian cotton sheets and minibars, alongside convenient valet parking, making for a truly indulgent stay.
  • Neighborhood: Bella Vista
  • Nearby attractions: Calle 50 - 0.43 miles, Uruguay Street - 0.34 miles, Avenida Balboa - 0.44 miles

Hotel Riu Plaza Panama

  • Why it's great for tailored spa getaway: For travelers who prioritize wellness and relaxation, Hotel Riu Plaza Panama is an ideal choice, an excellent guest review rating of 9.0. The hotel features a full-service spa with treatment rooms, ensuring guests can indulge in various pampering treatments and therapies designed to refresh the body and mind. An outdoor pool also provides a serene setting for relaxation after a spa session.
  • Other amenities: In addition to its spa amenities, guests can enjoy a complimentary buffet breakfast and an array of dining options, including a poolside bar for leisurely afternoons. The hotel also offers convenient amenities such as valet parking, a fitness center, and a shopping district on-site, making it a well-rounded destination for both relaxation and convenience.
  • Neighborhood: Bella Vista
  • Nearby attractions: Calle 50 - 0.0 miles, Uruguay Street - 0.91 miles, Via Espana - 0.61 miles

Top Panama City Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Looking to vacation at a spa hotel in Panama City?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers highly recommend Panama City for its array of shops and gourmet restaurants—your day tour starts here. Be sure to enjoy the cafes during your stay. Spa hotels are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Panama City?
Megapolis Hotel Panamá is a top luxury spa hotel featuring 3 bars, a casino, a shopping mall, and a rooftop terrace. Enjoy a facial, body scrub, or detox wrap at the onsite spa. Other popular spa hotels in Panama City include W Panama and Las Americas Golden Tower Panama.
How many spa hotels are there in Panama City?
Expedia has 24 spa hotels to choose from in Panama City.
What's there to see and do in Panama City?
Enjoy Panama City with a stop at Albrook Shopping Mall, Via Espana, and Iglesia del Carmen. If you have a little extra time during your trip, you might want to check out Uruguay Street and Crown Casino.
What is a Panama City spa hotel?
Spa hotels in Panama City have full on-site spas which offer services like massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.