Find hotels in South San Francisco, CA from ₩86,856
Change your mind
Be picky
Go beyond your typical stay in South San Francisco
Check prices for these dates
Compare 4,900 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.
Our top choices for South San Francisco hotels

DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd

La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North

Sonesta Select San Francisco Airport Oyster Point Waterfront
Sonesta Select San Francisco Airport Oyster Point Waterfront

Hotel Focus SFO
Hotel Focus SFO

Embassy Suites by Hilton San Francisco Airport Oyster Point
Embassy Suites by Hilton San Francisco Airport Oyster Point
Check out hotels with an airport shuttle in South San Francisco

DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
Hotels with free breakfast in South San Francisco you'll enjoy

DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
These family-friendly hotels in South San Francisco may fit your trip

Embassy Suites by Hilton San Francisco Airport Oyster Point
Embassy Suites by Hilton San Francisco Airport Oyster Point
Where to stay in South San Francisco

Downtown South San Francisco
Downtown South San Francisco blends business energy with cultural richness just minutes from San Francisco proper. Modern biotech campuses stand alongside vibrant ethnic markets on Grand Avenue. The neighborhood hums with professional activity while celebrating its diverse heritage through colorful murals. This well-connected hub offers excellent transportation options via BART and Caltrain stations. Authentic dining reflects the area's Hispanic and Asian communities. After business hours, the atmosphere becomes quietly residential with limited evening entertainment.

Oyster Point
Oyster Point blends sleek biotech campuses with refreshing waterfront beauty along San Francisco Bay. Modern glass buildings reflect the calm waters where walking paths invite you to explore. The area showcases contemporary plazas and public art installations throughout the business district. Corporate lunch spots serve the weekday crowd while evening options remain limited. The Bay Trail offers panoramic views and peaceful walks away from the office buzz. Visitors can observe both cutting-edge architecture and natural bay ecosystems during business hours.
The East Side
The East Side of South San Francisco blends cultural diversity with suburban charm just minutes from San Francisco Bay. Hispanic and Asian communities contribute authentic flavors to local eateries along Grand Avenue. Views of San Bruno Mountain create a distinctive backdrop for this working-class neighborhood. Visitors can explore Orange Memorial Park's recreational areas or hike nearby mountain trails. Budget-conscious travelers appreciate the area's affordable dining options and practical accommodations. Easy connections to BART and Caltrain make exploring the greater Bay Area convenient without downtown's premium prices.

Paradise Valley
Paradise Valley offers a quiet retreat from San Francisco's hustle while keeping you connected to the Bay Area. This peaceful residential neighborhood boasts wide streets and modest homes where local families live their everyday lives. Travelers appreciate the genuine suburban atmosphere and significantly lower prices than downtown. Just minutes from San Francisco International Airport, Paradise Valley serves as a practical base for exploring the region. Small local parks provide green spaces for relaxation. Though lacking tourist attractions within its boundaries, the neighborhood's proximity to major highways makes Bay Area adventures easily accessible.
Serra Highlands
Serra Highlands offers a peaceful retreat from the Bay Area bustle. This quiet neighborhood features hillside streets lined with mid-century ranch homes and contemporary houses. Morning fog creates a mystical atmosphere while eucalyptus-scented air refreshes the senses. Panoramic vistas of San Francisco Bay reward those who explore the residential streets. Small neighborhood parks and green corridors provide pleasant walking opportunities. Though dining and shopping options are limited within the area, the authentic suburban charm makes it worth the short drive to nearby commercial districts.
Stay near popular South San Francisco attractions

Golden Gate Park
This beloved park offers relaxation among trees, flowers and wildlife, right in San Francisco’s backyard.

Pier 39
This waterfront attraction offers thrilling rides, innovative street performers and colorful souvenir shops, but it’s the sea lions that win the day.
Learn more about South San Francisco
South San Francisco is calling! Discover its food, castle, sightseeing, and more.

Top South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Fairmont San Francisco
More cheap stays in South San Francisco
More cheap stays in South San Francisco

The Marina Inn on San Francisco Bay
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in South San Francisco Neighborhoods
Stay near popular South San Francisco attractions
- Hotels near Stanford University
- Hotels near Golden Gate Park
- Hotels near Pier 39
- Hotels near Golden Gate Bridge
- Hotels near Oracle Park
- Hotels near Chase Center
- Hotels near Moscone Convention Center
- Hotels near Alcatraz Island
- Hotels near Presidio of San Francisco
- Hotels near Lombard Street
- Hotels near Muir Woods National Monument
- Hotels near University of California
- Hotels near Oakland-Alameda County Coliseum
More Hotel Options in South San Francisco
Hotels near South San Francisco Airports
Other Hotels near South San Francisco, San Francisco
- Berkeley Hotels
- Palo Alto Hotels
- Half Moon Bay Hotels
- Fremont Hotels
- Sausalito Hotels
- Burlingame Hotels
- San Mateo Hotels
- Redwood City Hotels
- Pacifica Hotels
- Mill Valley Hotels
- Hayward Hotels
- San Rafael Hotels
- Stinson Beach Hotels
- Daly City Hotels
- Emeryville Hotels
- Menlo Park Hotels
- San Bruno Hotels
- Alameda Hotels
- Millbrae Hotels
- San Carlos Hotels
Explore more hotels
- Handlery Union Square Hotel
- Parc 55 San Francisco - A Hilton Hotel
- Mayflower Hotel
- Fairmont San Francisco
- Hotel Zoe Fisherman's Wharf
- Chancellor Hotel on Union Square
- Hotel Caza Fisherman's Wharf
- Hyatt Centric Fisherman's Wharf San Francisco
- FOUND Hotel Carlton, Nob Hill
- DoubleTree by Hilton Hotel Berkeley Marina