Top Uptown Hotels

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Where to stay in Uptown

Find the best Uptown areas and neighborhoods for the activities you enjoy most.

Aerial panorama of Beaufort, South Carolina with cruise ship in port.

Historic District

If you're spending some time in Historic District, Bay Street and Henry C. Chambers Waterfront Park are top sights worth seeing.

See properties

Downtown Beaufort

If you're spending some time in Downtown Beaufort, Henry C. Chambers Waterfront Park and Bay Street are top sights worth seeing.

See properties

Habersham

While there might not be top attractions in Habersham, you can explore the larger area and discover places like Highway 21 Drive-In Theater and Ocean Creek.

See properties

Historic Downtown

While visiting Historic Downtown, you might make a stop by sights like Henry C. Chambers Waterfront Park and Bay Street.

See properties

Northwest Quadrant

While there might not be top attractions in Northwest Quadrant, you can explore the larger area and discover places like Beaufort National Cemetery and Henry C. Chambers Waterfront Park.

See properties

Top Uptown Hotel Reviews

Spark by Hilton Bluffton Hilton Head Island

10/10 Excellent

"Clean accommodation's excellent loved it will continue to find use them on future travels ."

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

8/10 Good

"What I liked about the property was the convenience of the location to the event my family & I were attending. The hotel cleanliness was great. Our room was clean except for the mental door stripping that was not properly secured to the floor and my family member hit her toe on it. I immediatly took pictures and showed the pictures of the mental door stripping to the staff. They immediately called maintenance to fix the problem. I am thankful my family member didn't have to seek medical attention after hitting that metal stripping. The continental breakfast was good and there was plenty of choices to choose from. The staff was friendly & professional. Was looking forward to swimming in the pool but it was inoperable. However, Hilton next door allowed us to use their pool that was nice. I would stay there again especially if the venue I am going to is only 6 minutes away."

Red Roof Inn Hilton Head Island

2/10 Terrible

"I wish I can add pictures, room was disgusting dirty . Rolled flack hair is everywhere, old socks, previously left in a room… we couldn’t walk in the floors, was soooo dirty , I think outside was cleaner then inside. I would never recommend to stay there. I made a comment on google , property management apologize and ‘ hopped’ we coma back again. That’s is so crazy to me ."

Simple Rewards Inn

8/10 Good

"Great location, close to a lot of attractions, restaurants and shopping. Staff was great throughout our whole stay, and the facility was clean. Room and bathroom were clean with plenty of supplies, they even provided wipes and sanitizer in room. Office provided fresh fruit, muffins, snacks, water and coffee throughout the day. The only thing we didn’t have use of was the pool. Air conditioning in room worked great all day which was a blessing because he was definitely hot and muggy outside. I would definitely stay here again next time I visit Hilton Head Island."

Frequently asked questions

What's it like in Uptown?

Travelers will be sure to enjoy their time in Beaufort's Uptown neighborhood.

How many hotels should I expect to find in the Uptown area?

If you're searching for places to stay in Beaufort, choose from one of Expedia's 12 hotels and other accommodations in Uptown.

If I need to cancel my hotel reservation in Uptown, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer in Uptown.

Where can I learn more about changing or cancelling my trip to Uptown?

To find more details about updating your trip to Uptown or cancelling it, go to https://www.expedia.com/service/.

What is there to do in this Beaufort neighborhood?

A few places to visit in the area around Uptown include Beaufort National Cemetery, USCB Center for the Arts, and St. Helena's Episcopal Church. Beaufort Museum and Henry C. Chambers Waterfront Park are also worth a visit when you're out sightseeing in Beaufort.

Explore a world of travel with Expedia

More ways to book

Book Hotels in Uptown on Expedia.com

Find hotels in Uptown, Beaufort

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Uptown hotels

St Helena Island Condo w/ Beach Views & Porch!

The Westin Hilton Head Island Resort & Spa

Marriott's Barony Beach Club

607 Bay Inn Downtown Beaufort

City Loft Hotel

The Emerald Boutique Stays

Beaufort Inn

Best Western Sea Island Inn

Rhett House Inn

Steps to Pool & Beach: St. Helena Island Escape!

Anchorage 1770

Cuthbert House

Marriott's SurfWatch

Hampton Inn Hilton Head

Super 8 by Wyndham Port Royal/Beaufort

Hilton Head Resort

Hilton Garden Inn Beaufort

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

SpringHill Suites by Marriott Beaufort

Oasis Inn

Where to stay in Uptown

Historic District

Downtown Beaufort

Habersham

Historic Downtown

Northwest Quadrant

Top Uptown Hotel Reviews

Spark by Hilton Bluffton Hilton Head Island

Frequently asked questions

Explore a world of travel with Expedia