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Check prices for these dates

This weekend
May 29 - May 31
Next weekend
Jun 5 - Jun 7

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Our top choices for Cairo hotels

Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (285 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is ₩113,600
₩126,073 total
includes taxes & fees
Jun 14 - Jun 15
Quality Inn Cairo I-57
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
The price is ₩105,816
₩117,441 total
includes taxes & fees
May 31 - Jun 1
The Riverstone Hotel Charleston-Sikeston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (635 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is ₩92,513
₩102,671 total
includes taxes & fees
Jun 8 - Jun 9
Super 8 by Wyndham Charleston/Sikeston East MO
Basic Double Room | Living area

La Center Motel

La Center Motel
2.0 star property
La Center
7.4 out of 10, Good, (20 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is ₩81,629
₩95,491 total
includes taxes & fees
May 27 - May 28
La Center Motel
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is ₩108,083
₩119,949 total
includes taxes & fees
Jun 1 - Jun 2
Eagle Inn Charleston
House (2 Bedrooms) | Interior

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ₩182,910
₩438,334 total
includes taxes & fees
May 27 - May 28
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

3.7/5 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

La Center Motel

La Center Motel

4/10 Poor
"This property is very old & not updated. Our room was very stale smelling & I was concerned about the cleanness of the room. Nothing present in tub for handicapped or older people. The guy at the front desk was not friendly at all & was truly alarmingly strange acting. We were concerned. Only good thing was we were able to park the car right in front of our room."
Kathy 1-night trip
Posted 23 hours ago
La Center Motel

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
The price is ₩81,629 per night from May 27 to May 28
₩81,629
₩95,491 total
May 27 - May 28
includes taxes & fees
7.4/10 Good! (20 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 27 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

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