The Best Resorts & Hotels with Spas in Central Missouri, MO from ₩149,633 in 2026

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Our top choices for Central Missouri hotels with a spa

Couples treatment rooms, hot tub, body treatments, aromatherapy

Lodge Of Four Seasons Golf Resort, Marina & Spa

Lake Ozark

Luxurious lakeside retreat with rejuvenating spa treatments and tranquil Japanese gardens for ultimate relaxation.

₩227,089 total

includes taxes & fees

Jun 14 - Jun 15

Couples treatment rooms, body treatments, hydrotherapy, aromatherapy

Camden on the Lake Resort & Spa

Lake Ozark

Relax at this lakeside resort with four treatment rooms at Spa 54, featuring hot stone massages, hydrotherapy, and couples' services.

₩274,780 total

includes taxes & fees

Jun 28 - Jun 29

Margaritaville Lake Resort Lake of the Ozarks

Osage Beach

Lakeside spa resort with golf course offers rejuvenating massages, body treatments, and poolside relaxation.

₩359,664 total

includes taxes & fees

Jun 7 - Jun 8

Couples treatment rooms, steam room, body treatments

The Lodge at Old Kinderhook Golf Resort

Camdenton

Revitalize at this lakeside retreat with full-service spa, golf course, and dual pools for ultimate relaxation.

₩290,952 total

includes taxes & fees

Jun 1 - Jun 2

Couples treatment rooms, body treatments, aromatherapy

The Courtland Hotel and Day Spa

Fort Scott

Tranquil historic hotel offers rejuvenating spa escape with four serene treatment rooms for ultimate relaxation.

₩149,633 total

includes taxes & fees

Jun 7 - Jun 8

Couples treatment rooms, aromatherapy, hot stone massages

Hermann Hill

Hermann

Riverside bed and breakfast with private hot tubs and spa treatments offers romantic rejuvenation.

₩553,958 total

includes taxes & fees

Jun 23 - Jun 24

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Choose what matters most at spa hotels in Central Missouri

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Breakfast included

Top Central Missouri Hotel Reviews

Inn at Grand Glaize

10/10 Excellent

"People were nice"

Econo Lodge Truman Inn

2/10 Terrible

"I booked it online based on the price and availability. I booked it a few minutes from pulling in. From the outside, like the pictures online, it seemed okay. Maybe not the nicest but we needed a room as we were traveling. I walked in with our small children and was blown away. It was awful! Very dirty, smelled like mold with old broken and stained furniture in the lobby, Because we had our kids they wanted to check out the pool so we did and it looked like a dungeon. I'm not even sure if it was in service. We turned around and walked out. I called the front desk and was polite and didn't want to be disrespectful to their place so I said that I rented it in error, which in my eyes I did because if I knew it would be in the shape it was I never would've booked it. They lady I spoke with said that I needed to call Expedia. When I called the gentleman I spoke to seemed helpful and said he would need to call the hotel to see if they would approve a refund. Evidently he spoke to the same person I did because she remembered me calling. She denied my refund. It was so bad that I didn't stay even though I was required to pay for it. We ended up driving 30 mins to Warrensburg and staying there. We had a MUCH better experience there. I would highly recommend moving down the road if this hotel is your only option!"

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Book Resorts & Hotels with Spas in Central Missouri on Expedia.com

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Change your mind

Treat yourself

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Check availability on Central Missouri Resorts & Hotels with Spas

Our top choices for Central Missouri hotels with a spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

Camden on the Lake Resort & Spa

Margaritaville Lake Resort Lake of the Ozarks

The Lodge at Old Kinderhook Golf Resort

The Courtland Hotel and Day Spa

Hermann Hill

Choose what matters most at spa hotels in Central Missouri

Top Central Missouri Hotel Reviews

Inn at Grand Glaize

Stoney Creek Hotel Columbia

Margaritaville Lake Resort Lake of the Ozarks

Country Inn & Suites by Radisson, Columbia, MO

Lodge Of Four Seasons Golf Resort, Marina & Spa

Wingate by Wyndham - Columbia

Baymont by Wyndham Rolla

Econo Lodge Truman Inn

Explore a world of travel with Expedia

Find Resorts & Hotels with Spas in Central Missouri, MO

Change your mind

Treat yourself

Be picky

Check availability on Central Missouri Resorts & Hotels with Spas

Our top choices for Central Missouri hotels with a spa

Lodge Of Four Seasons Golf Resort, Marina & Spa

Camden on the Lake Resort & Spa

Margaritaville Lake Resort Lake of the Ozarks

The Lodge at Old Kinderhook Golf Resort

The Courtland Hotel and Day Spa

Hermann Hill

Choose what matters most at spa hotels in Central Missouri

Top Central Missouri Hotel Reviews

Inn at Grand Glaize

Explore a world of travel with Expedia