Find hotels in East Prairie, MO from ₩86,148

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Our top choices for East Prairie hotels

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1008)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ₩97,314
₩110,915 total
includes taxes & fees
Jan 18 - Jan 19
Best Western Plus Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (445)
Discover comfort at this Sikeston hotel with an indoor pool and fitness center. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.

"Stay was excellent "
United States
Kourtney
The price is ₩134,796
₩152,623 total
includes taxes & fees
Jan 25 - Jan 26
Holiday Inn Express & Suites Sikeston Southwest by IHG

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"Great place. Friendly staff clean"
United States
Jeff
The price is ₩130,433
₩149,957 total
includes taxes & fees
Jan 12 - Jan 13
Drury Inn & Suites Sikeston, MO

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness center keeps your routine intact while complimentary breakfast energizes your day exploring nearby Central Park and Sikeston Depot Museum.

"Very clean, very friendly! We will be staying again. "
United States
Beth
The price is ₩108,580
₩124,826 total
includes taxes & fees
Jan 12 - Jan 13
Pear Tree Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (459)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness center. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.

"Very clean and super friendly staff!"
United States
Katherine
The price is ₩148,797
₩168,475 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn Sikeston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (328)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness center, making your Tennessee adventure complete.

"The rooms are big and the property is spotless!"
United States
debbie
The price is ₩115,978
₩137,724 total
includes taxes & fees
Jan 19 - Jan 20
Sleep Inn at Discovery Park of America

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (733)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.

"Friendly sta"
United States
Melissa
New Orleans Inn Portageville

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (727)
Enjoy tranquil accommodations at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Clean room and easy access to room"
United States
Anne
The price is ₩80,428
₩91,667 total
includes taxes & fees
Jan 11 - Jan 12
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (550)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Center nearby. Guests consistently praise the clean rooms and helpful staff.

"Roaches!"
United States
Teresa
The price is ₩114,661
₩136,163 total
includes taxes & fees
Jan 10 - Jan 11
Country Hearth Inn & Suites Union City

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (490)
Unwind at this Union City hotel offering a seasonal outdoor pool and hot tub for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Center, guests enjoy free breakfast, WiFi, and parking.

"Nice room"
Mexico
José Ricardo
The price is ₩97,329
₩115,577 total
includes taxes & fees
Feb 1 - Feb 2
Quality Inn Union City US 51

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (579)
Start your day with complimentary breakfast at this Sikeston hotel. Enjoy free WiFi and parking while staying minutes from Central Park and the Sikeston Depot Museum. Cape Girardeau Municipal Airport is just a 29-minute drive away.

"Great place"
United States
Misty
The price is ₩86,096
₩98,141 total
includes taxes & fees
Jan 11 - Jan 12
Super 8 by Wyndham Sikeston/Miner Area

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness center.

"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is ₩144,942
₩172,118 total
includes taxes & fees
Feb 6 - Feb 7
Holiday Inn Express & Suites Union City by IHG

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (284)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness center. Near Central Park and Sikeston Depot Museum, travelers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.

"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is ₩127,996
₩145,884 total
includes taxes & fees
Jan 13 - Jan 14
Comfort Inn & Suites Sikeston I-55

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
This tranquil Sikeston hotel offers complimentary on-the-go breakfast and WiFi, plus convenient access to Central Park and Sikeston Depot Museum. Guests appreciate the helpful staff, clean rooms, and free parking, with a fitness center for morning workouts.

"A great stay in every aspect. "
United States
Gertrude
The price is ₩91,074
₩103,803 total
includes taxes & fees
Jan 11 - Jan 12
Days Inn and Suites by Wyndham Sikeston

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (167)
Located near County Market Place and Reelfoot Shopping Center, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.

"Staff was great. Room was ready and clean. "
United States
Robert
The price is ₩155,233
₩184,340 total
includes taxes & fees
Jan 18 - Jan 19
Hampton Inn Union City

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (48)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ₩146,240
₩165,580 total
includes taxes & fees
Jan 29 - Jan 30
Fairfield Inn & Suites by Marriott Sikeston

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
This Sikeston motel offers a convenient base for exploring nearby Central Park and Sikeston Depot Museum. Enjoy thoughtful amenities like free WiFi and parking alongside 24-hour front desk service for assistance anytime.

"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is ₩77,377
₩92,059 total
includes taxes & fees
Jan 14 - Jan 15
Country Yard Inn and Suite

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The onsite health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.

"Middle of nowhere hotel was ok"
United States
David
The price is ₩87,585
₩97,199 total
includes taxes & fees
Jan 13 - Jan 14
Eagle Inn Charleston

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (42)
This hotel in Marston offers complimentary perks including daily full breakfast served between 6:00 AM and 9:00 AM, WiFi, and self parking. Conveniently located for travelers exploring the area.

"Great hotel, great staff"
United States
Dmitry
The price is ₩83,473
₩95,348 total
includes taxes & fees
Jan 20 - Jan 21
Super 8 By Wyndham Marston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (11)
Set near Central Park and Sikeston Depot Museum, this business-friendly hotel offers a refreshing indoor pool and convenient daily breakfast. Enjoy well-appointed accommodations with complimentary WiFi and self parking just 32 minutes from Cairo Regional Airport.

"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is ₩164,918
₩186,729 total
includes taxes & fees
Jan 18 - Jan 19
TownePlace Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Best Western Plus Sikeston. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 32 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and New Madrid Historical Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.