The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Search Vacation Homes in Mayo River

Change your mind

Book hotels with free cancellation

Treat yourself

Be picky

Search almost a million properties worldwide

Check prices for these dates

Next weekend

In two weeks

In one month

In two months

Vacation Homes in Mayo River

Save an average of 15% on thousands of hotels when you're signed in

Find out more about Mayo River

Mayo River Vacation Homes information

Number of reviews
Accommodation	Vacation Homes
Lowest Price
Highest Price

Recent reviews of Mayo River hotels

5/5 Excellent

"This was recommended and it did not disappoint!!!!!!"

A verified traveler stayed at Hotel Floyd

Posted 2 days ago

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Members save 10% or more on over 100,000 hotels worldwide when you’re signed in

Search Vacation Homes in Mayo River

Change your mind

Treat yourself

Be picky

Check prices for these dates

Vacation Homes in Mayo River

Find out more about Mayo River

Mayo River Vacation Homes information

Recent reviews of Mayo River hotels

Hotel Floyd

Hampton Inn Martinsville

Baymont by Wyndham Eden

Moonlight Manor Bed and Breakfast

Scottish Inns Collinsville-Martinville

Virginian Motel

Tuggle's Gap Roadside Inn - Blue Ridge Parkway

Hampton Inn Eden

Comfort Inn

Explore a world of travel with Expedia

More Accommodation Types in Mayo River

All Accommodation Types

More ways to book

Expedia's Latest Trends