The Best Hotels Closest to Mississippi River in for 2026

A bridge spanning a body of water with a city skyline in the background during sunset.

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Our top choices for Mississippi River hotels

A hotel room with a desk, a chair, a television, and a patterned armchair.

A gazebo with a table and benches, surrounded by trees and a body of water.

A hotel room with a desk, a television, a chair, a small refrigerator, a lamp, and a plant.

A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.

1. River's Edge Motel

13.6 km from Mississippi River

₩111,303

₩126,376 total

includes taxes & fees

Oct 18 - Oct 19

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

2. Sleep Inn & Suites Hannibal West

30.3 km from Mississippi River

Patricia

₩158,439

₩184,343 total

includes taxes & fees

Nov 8 - Nov 9

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.

A bedroom with a brick wall, a wooden bed, two bedside tables with lamps, and a ceiling fan.

A staircase with wooden steps and a wooden handrail, leading up a brick wall.

3. The Eagles Nest Inn

14.2 km from Mississippi River

Kimberly

₩156,897

₩178,137 total

includes taxes & fees

Nov 5 - Nov 6

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

4. Best Western On The River

25.3 km from Mississippi River

Wei

₩147,497

₩170,133 total

includes taxes & fees

Oct 28 - Oct 29

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A compact kitchen with a refrigerator, microwave, and sink.

A historic building with a stone facade and multiple windows, featuring a sign about Tom Sawyer's fence.

A wooden table with a bottle of champagne, two glasses, and scattered rose petals.

5. Riverside Inn Hannibal

25.1 km from Mississippi River

Janee

₩201,693

₩279,124 total

includes taxes & fees

Oct 18 - Oct 19

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.

6. Quality Inn & Suites Hannibal West

30 km from Mississippi River

Gayle

₩101,339

₩117,908 total

includes taxes & fees

Nov 8 - Nov 9

A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

A compact living space with a kitchenette, a sofa, a patterned armchair, and a television.

A lobby with a reception desk, seating area, and a staircase.

7. Heritage Hotel Quincy

47.8 km from Mississippi River

Amy

₩104,437

₩119,037 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with a bed, a lamp, a mirror, and a door.

A grand, circular staircase with white balustrades and a chandelier in the center.

A Town & Country Inn and Suites building with a prominent entrance, multiple windows, and a green roof.

A swimming pool with lounge chairs and sunbathing areas.

8. Town & Country Inn and Suites

45.2 km from Mississippi River

Tracy

₩167,755

₩191,208 total

includes taxes & fees

Oct 19 - Oct 20

A hotel room with a bed, a sofa, a desk, and a lamp.

A restaurant with multiple tables and chairs, an exit sign, and a counter area.

An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.

A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.

9. Comfort Inn & Suites - Hannibal

26.2 km from Mississippi River

Jerry

₩102,828

₩122,636 total

includes taxes & fees

Nov 15 - Nov 16

A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

An outdoor patio with tables and chairs, green umbrellas, and string lights.

A spacious lobby with a fireplace, seating area, and large windows.

A hotel room with a sofa, armchair, lamp, and a large mirror.

10. Holiday Inn Quincy East by IHG

46.1 km from Mississippi River

Colleen

₩143,487

₩163,546 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

A coffee station with a coffee machine, cups, and a sign that says "RISE & SHINE."

A building with a covered entrance and a sign indicating a clearance height of 13 feet.

A hotel room with two beds, a window with red curtains, an air conditioning unit, and two bedside lamps.

11. Motel 6 Hannibal, MO

26.1 km from Mississippi River

Jared

₩77,765

₩89,700 total

includes taxes & fees

Oct 20 - Oct 21

A reception area with a marble counter, a 'Days Inn' sign, and a welcome mat.

A hotel with a covered entrance, a parking lot, and a clear sky.

A hotel room with two beds, a desk with a computer, a television, and a small seating area.

A hotel room with a dining area, kitchenette, and a door leading to a hallway.

12. Days Inn by Wyndham Hannibal

26.4 km from Mississippi River

Christian

₩84,483

₩97,451 total

includes taxes & fees

Oct 28 - Oct 29

A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

A hotel room with a large bed, a desk with a chair, a window with curtains, and a wall-mounted artwork.

A patio with red Adirondack chairs and a table, surrounded by a pebble border.

A long hallway with a patterned carpet, wooden paneling on the walls, and a ceiling light.

13. Super 8 by Wyndham Hannibal

26.3 km from Mississippi River

Betty

₩82,807

₩95,518 total

includes taxes & fees

Oct 21 - Oct 22

A hot tub with a rocky backdrop and a mural.

A restaurant with wooden walls, a bar area, and multiple seating arrangements.

An indoor swimming pool with a 'No Diving' sign, lounge chairs, and a mural on the wall.

An outdoor patio area with wooden furniture, string lights, and umbrellas.

14. Stoney Creek Inn Quincy

46.5 km from Mississippi River

Kent

₩161,731

₩184,340 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

A reception area with a reception desk, seating area with chairs, a patterned rug, and a large window with a view of the outside.

A modern kitchen with dark cabinets, a central island with bar stools, and pendant lighting.

A hotel room with a bed, a desk with a chair, a television, and a dining area with chairs.

15. Quality Inn & Suites Quincy - Downtown

47.8 km from Mississippi River

Bryan

₩148,918

₩169,737 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A swimming pool with lounge chairs and a covered seating area.

16. Lighthouse Inn & Suites

25.8 km from Mississippi River

Connie

₩213,902

₩293,200 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

17. Drury Inn & Suites St. Louis St. Peters

95.3 km from Mississippi River

Ashley

₩147,497

₩169,547 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a dining area, a bar, and a fireplace.

A snack shelf stocked with various chips and snacks, a mini-fridge with beverages, and a small refrigerator with hot food items.

An indoor swimming pool with clear blue water, yellow and white lounge chairs, and a clock on the wall.

A neatly made bed with white linens, a wooden headboard, two bedside tables with lamps, a blue chair, and a framed picture on the wall.

18. Fairfield Inn & Suites Quincy

46 km from Mississippi River

Chris

₩158,439

₩180,589 total

includes taxes & fees

Nov 1 - Nov 2

A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

A kitchen with wooden cabinets, a granite countertop, and various food items and kitchen appliances.

A clean, modern reception area with a reception desk, a clock, and a potted plant.

A modern building with a red awning, a parking lot, and a sign indicating an entrance.

19. Howard Johnson BY Wyndham Hannibal

26.3 km from Mississippi River

Debbie

₩78,448

₩91,097 total

includes taxes & fees

Nov 15 - Nov 16

A large indoor swimming pool with a lifeguard chair, poolside chairs, and a view of the outside through large windows.

A Hampton Inn hotel with a covered entrance, a well-lit facade, and a landscaped front yard.

A breakfast buffet area with a sign reading "EAT HERE" and various food items like cereal and pastries.

A modern hotel room with a large bed, two bedside tables with lamps, a small sofa, and a desk.

20. Hampton Inn Keokuk

98.9 km from Mississippi River

Kristopher

₩135,642

₩151,919 total

includes taxes & fees

Nov 1 - Nov 2

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Compare popular hotels close to Mississippi River

Property	Property class	Guest rating
River's Edge Motel	9.0 Wonderful 393 reviews	View
Sleep Inn & Suites Hannibal West	9.6 Exceptional 1,000 reviews	View
The Eagles Nest Inn	9.6 Exceptional 27 reviews	View
Best Western On The River	8.6 Excellent 1,004 reviews	View
Riverside Inn Hannibal	9.6 Exceptional 201 reviews	View

Top Mississippi River Hotel Reviews

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Fantastic place to stay! The staff was amazing!"

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"The all day free fountain soda machine was fantastic! The view was great and overall experience was wonderful. I will stay here again!"

Pear Tree Inn St. Louis Airport

10/10 Excellent

"Nice and clean. Breakfast delicious 😋"

Live by Loews - St.Louis

10/10 Excellent

"Staff were very helpful and friendly.."

Ameristar Casino Resort and Spa

10/10 Excellent

"Very clean and professional"

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"Very clean and spacious room!"

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

10/10 Excellent

"Very cute hotel. Definitely would stay again. We were busy this trip so didn’t have time to check out the rooftop bar. Would have liked to have done that."

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)

You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savor the top-notch restaurants.

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Sawyer's Creek Fun Park

7.8/10 (16 reviews)

Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savor the top-notch restaurants.

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Lovers Leap

8.8/10 (171 reviews)

Find out about the history of Hannibal with a stop at Lovers Leap. While in this walkable area, you can savor the top-notch restaurants.

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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Bluff City Theater

7.6/10 (5 reviews)

Enjoy a show at Bluff City Theater, a theater with a story to tell in Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Planters Barn Theater

8.8/10 (22 reviews)

Enjoy a show at Planters Barn Theater, a storied theater in Hannibal. While in this walkable area, you can savor the top-notch restaurants.

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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)

Find out about the history of Hannibal when you take a trip to Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savor the top-notch restaurants.

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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)

You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your travels to Hannibal. While in this family-friendly area, you can savor the top-notch restaurants.

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Find out more about Mississippi River

Top reasons to visit Mississippi River

Vibrant Activities: Enjoy baseball games, live music, and various sports along the river.
Cultural Heritage Festivals: Experience local culture at heritage festivals featuring food and music.
Outdoor Adventures: Engage in river studies, bird watching, and scenic day trips to appreciate nature.
Historic Attractions: Discover historic houses, museums, and caves that showcase the region's rich history.
Diverse Accommodations: Choose from cozy Bed & Breakfasts or comfortable hotels for a relaxing stay.

Find great hotels near Mississippi River

Discover the charm of the Mississippi River with a variety of accommodation options, including cozy Bed & Breakfasts and inviting guesthouses. Whether you're seeking family-friendly amenities, historic themes, or pet-friendly spaces, there's something for everyone. Explore the unique offerings of La Salle and unwind in wilderness cabins or stay at well-known chains like Hampton Inn for a comfortable retreat during your adventure along this iconic waterway.

Super 8 by Wyndham Bowling Green: Located 24km from the Mississippi River, Super 8 by Wyndham Bowling Green offers budget-friendly lodging with a guest rating of 8.4 out of 10. This hotel is ideal for travelers looking for affordability without sacrificing comfort. Guests can enjoy complimentary breakfast options available daily, including a to-go breakfast. The property features entertainment amenities such as a television with premium channels and a DVD player, ensuring a relaxing stay after a day of exploration.
River's Edge Motel: Just 13km away from the Mississippi River, River's Edge Motel boasts a commendable guest rating of 9.0 out of 10. This pet-friendly motel caters to travelers wishing to bring their furry companions along, with specific pet policies in place. Guests can expect a comfortable stay with amenities that accommodate pets, including fee waivers for service animals. The cozy atmosphere and proximity to the river make it a great choice for those seeking a relaxing getaway with their pets.
Riverside Inn Hannibal: Situated 26km from the Mississippi River, Riverside Inn Hannibal features guesthouse-style lodging with an impressive rating of 9.4 out of 10. The property offers dining at its on-site restaurant and a variety of entertainment options, including televisions equipped with Hulu and access to first-run movies. With a location near local attractions like the entertainment district and historical sites, it provides an engaging experience for guests looking to explore the charm of Hannibal.

Where to stay near Mississippi River

Your vacation along the Mississippi River promises a delightful blend of experiences, from the vibrant cities of Minneapolis and St. Louis to the serene landscapes of the Mississippi Delta. Enjoy friendly interactions with locals, explore family-friendly attractions, and embark on relaxing excursions along the scenic rivers. Don't miss the beautiful Minnesota River and the charming Iowa River, both offering unique atmospheres that highlight the warmth and hospitality of the region.

Louisiana: Nestled 14km from the Mississippi River, Louisiana offers a blend of outdoor adventure and scenic beauty. With visitor numbers peaking in April, July, and September, this city is a popular destination for those seeking a romantic getaway or a peaceful retreat. The recreational areas and vibrant theater scene provide entertainment options for all ages. Visitors can enjoy the stunning views of the nearby river and lake, along with the natural wonders found in the state park. Louisiana is perfect for travelers looking to immerse themselves in nature while enjoying a relaxed urban atmosphere.
New Canton: Located 11km away from the Mississippi River, New Canton is an inviting city that attracts families and outdoor enthusiasts alike. With peak travel seasons in January to February, April, August, and November, visitors can enjoy a variety of activities, including golfing at local courses and exploring the natural history museum. This city is ideal for those who appreciate the beauty of the environment and want to create family memories in a charming setting. The proximity to the river and lake adds to the scenic allure, making it a delightful spot for outdoor excursions.
Rockport: Just 13km from the Mississippi River, Rockport is a vibrant city known for its family-friendly atmosphere and urban charm. Peak visitor months include May, July, and September, attracting those interested in city-themed experiences and outdoor fun. Rockport offers a range of activities, including educational experiences, theater performances, and golfing opportunities. Visitors can explore the local urban park, delve into history at the museum, or enjoy the lively campus of the modern college university nearby. Rockport is a city that beautifully balances culture, education, and outdoor recreation.

Things to do in Mississippi River

Shopping

Visit the River Market in Downtown Memphis for local crafts and unique souvenirs. If you're up for a drive, check out the Mall of America in Bloomington, located over 16km away, featuring a wide range of shops, dining options, and entertainment to explore.

Recreation

In Mississippi, the River Valley Wellness offers yoga sessions and meditation workshops amidst serene landscapes. Nearby, the Golden Triangle offers nature trails for hiking and biking, allowing guests to immerse themselves in the tranquil environment while enjoying local flora and fauna.

Adventure

Experience the thrill of kayaking on the Mississippi River, where you can paddle through stunning landscapes and observe local wildlife. For the adventurous, join a riverboat cruise to enjoy breathtaking views while learning about the river's rich history and culture. Don’t miss the chance to fish in its abundant waters.

Nightlife

The nightlife along the Mississippi River offers vibrant experiences. Check out the lively bars in New Orleans for jazz and cocktails, or enjoy a riverboat cruise with dinner and entertainment. In Memphis, the Beale Street scene showcases blues music and bustling venues, perfect for a fun night out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mississippi River

The Mississippi River offers a variety of attractions for tourists, including historic houses, caves, and museums, perfect for those seeking cultural, outdoor, and adventurous experiences. Explore the amazing Mississippi River, its stunning delta, and the mighty upper Mississippi, or delve into the rich history of American rivers. There’s something for everyone to enjoy along this iconic waterway.

Mark Twain Boyhood Home and Museum: Located 26km from the Mississippi River, this historic site offers a glimpse into the early life of Samuel Clemens, better known as Mark Twain. Explore the charming home and engaging exhibits that reflect the culture and history of the time, enhancing your appreciation for Twain's literary contributions.
Mark Twain Cave: Situated 23km from the Mississippi River, this cave invites adventure enthusiasts to explore its winding passages. Discover the natural beauty of the cave while learning about its historical significance to Twain, who often drew inspiration from its depths for his writing.
Mark Twain Memorial Lighthouse: At 26km from the Mississippi River, this historic lighthouse stands as a tribute to Twain's legacy. Climb to the top for a stunning view of the river and the surrounding landscape, immersing yourself in the culture that inspired one of America's greatest authors.

The nearest major airports for your trip to Mississippi River

Traveling to the Mississippi River is easy with several nearby airports. Columbia Regional Airport (COU) is 122km away, with hotel options like The Broadway Columbia - a DoubleTree by Hilton, and voco The Tiger Hotel, both 18km from the airport. Lambert-St. Louis International Airport (STL) is 113km away, featuring luxury accommodations such as The Ritz-Carlton and Ameristar Casino Resort, both 11km from STL. Greater Peoria Regional Airport (PIA) is 175km away, with hotels like Embassy Suites by Hilton and Peoria Marriott Pere Marquette, both within 10km. Each hotel offers various transportation services to their respective airports.

Frequently asked questions

What's the area like around Mississippi River?

Mississippi River is located in an area that travelers like for its baseball games. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.

What's the best place to stay close to Mississippi River?

Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveler data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.

If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?

Yes, you'll find most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get top deals close to Mississippi River.

Where can I learn more about changing or cancelling my trip in the area near Mississippi River?

For additional details about updating your stay near Mississippi River or cancelling it, head over to our customer service page.

Find hotels near Mississippi River, from ₩89,700

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Be picky

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Our top choices for Mississippi River hotels

1. River's Edge Motel

2. Sleep Inn & Suites Hannibal West

3. The Eagles Nest Inn

4. Best Western On The River

5. Riverside Inn Hannibal

6. Quality Inn & Suites Hannibal West

7. Heritage Hotel Quincy

8. Town & Country Inn and Suites

9. Comfort Inn & Suites - Hannibal

10. Holiday Inn Quincy East by IHG

11. Motel 6 Hannibal, MO

12. Days Inn by Wyndham Hannibal

13. Super 8 by Wyndham Hannibal

14. Stoney Creek Inn Quincy

15. Quality Inn & Suites Quincy - Downtown

16. Lighthouse Inn & Suites

17. Drury Inn & Suites St. Louis St. Peters

18. Fairfield Inn & Suites Quincy

19. Howard Johnson BY Wyndham Hannibal

20. Hampton Inn Keokuk

Compare popular hotels close to Mississippi River

Top Mississippi River Hotel Reviews

Hampton Inn St. Charles St. Peters

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Airport

Live by Loews - St.Louis

Ameristar Casino Resort and Spa

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Other attractions near Mississippi River

Mark Twain Cave

Sawyer's Creek Fun Park

Lovers Leap

Sodalis Nature Preserve

Bluff City Theater

Planters Barn Theater

Mark Twain Boyhood Home and Museum

Jim's Journey: The Huck Finn Freedom Center

Find out more about Mississippi River

Top reasons to visit Mississippi River

Find great hotels near Mississippi River

Where to stay near Mississippi River

Things to do in Mississippi River

Find the best attractions near Mississippi River

The nearest major airports for your trip to Mississippi River

Frequently asked questions