Otay Mesa Vacations

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

4 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩245,650 per night from Jan 11 to Jan 12
₩245,650
₩346,318 total
Jan 11 - Jan 12
includes taxes & fees
8.2/10 Very Good! (3,226 reviews)
The room was beautiful

Reviewed on Jan 8, 2026

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩179,908 per night from Jan 25 to Jan 26
₩179,908
₩206,796 total
Jan 25 - Jan 26
includes taxes & fees
9/10 Wonderful! (3,273 reviews)
When I arrived at the hotel, the hotel clerk kindly checked me in and noticed that my wife looked sick. My wife had gotten carsick on the ride to Sand Diego. The clerk asked if she could get my wife some ginger ale. I took her up on this. This was just one of many positive interactions I had with ...

Reviewed on Jan 9, 2026

Bay Club Hotel & Marina
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
Fully refundableReserve now, pay when you stay
The price is ₩202,816 per night from Jan 19 to Jan 20
₩202,816
₩235,155 total
Jan 19 - Jan 20
includes taxes & fees
8.8/10 Excellent! (191 reviews)
I enjoyed the stay. Staff was pleasant just upset the ice machine didn’t work and could of used more towels

Reviewed on Jan 5, 2026

Courtyard by Marriott San Diego Downtown Little Italy
See all 4,868 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as , a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
Balboa Park which includes a pond

Balboa Park

Culture and nature converge in this diverse park located in the heart of the city.

Balboa Park
USS Midway Museum which includes military items

USS Midway Museum

Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.

USS Midway Museum
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.