A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Sep 11 - Sep 13
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Sep 18 - Sep 20

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ₩172,781
₩193,434 total
Oct 4 - Oct 5
Wyndham Guayaquil Puerto Santa Ana
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (63 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₩143,514
₩144,854 total
Sep 12 - Sep 13
River View suites Puerto Santa Ana gye

3. HOTEL MILENIO

HOTEL MILENIO
2.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
The price is ₩30,391
₩30,391 total
Sep 12 - Sep 13
HOTEL MILENIO
A cocktail on a marble table with a pool in the background.

4. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very Good, (165 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ₩59,375
₩60,715 total
Sep 12 - Sep 13
Hotel Patrimonial by Greenfield
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

5. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ₩79,596
₩88,896 total
Sep 15 - Sep 16
Mansión del Río
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

6. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Pool is surrounded by the dining area, it made it more a chill space than lounge. The hotel great service, very accommodating and noticeable security around the premises"
United States
tahiane
The price is ₩101,509
₩113,685 total
Oct 3 - Oct 4
Grand Hotel Guayaquil, Centro Histórico.
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

7. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₩450,240
₩500,959 total
Sep 12 - Sep 13
Hotel Río Guayas by Art Hotels Ecuador
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

8. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very Good, (411 reviews)
"Love the area where the hotel is located. Excellent breakfast. The pool area is beautiful where you can seat and relax "
United States
Sixto
The price is ₩84,421
₩85,761 total
Sep 13 - Sep 14
Hotel Ramada
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

9. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Very nice stay"
United States
Freddy
The price is ₩124,620
₩140,432 total
Sep 20 - Sep 21
Oro Verde Guayaquil

10. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (658 reviews)
"My parents had a great time at this hotel so much that will come in 2 weeks! Friendly staff and secure place."
United States
Beatriz
The price is ₩48,595
₩49,945 total
Sep 12 - Sep 13
DC Suites Aeropuerto
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

11. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (950 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ₩86,725
₩97,407 total
Sep 20 - Sep 21
Hotel Palace Guayaquil
A building with a traditional architectural style, featuring a prominent entrance with a set of stairs leading up to a double door.

12. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 3.5 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (181 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ₩141,102
₩142,442 total
Sep 12 - Sep 13
Luxva Hotel Boutique
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

13. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (9 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ₩66,330
₩67,670 total
Sep 15 - Sep 16
Fortune Hotel
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

14. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ₩115,426
₩128,994 total
Sep 12 - Sep 13
Wyndham Garden Guayaquil
A hotel room with a bed, a nightstand, a desk, a chair, and a window with curtains.

15. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very Good, (123 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ₩36,180
₩37,520 total
Sep 19 - Sep 20
Hotel Las Peñas
A buffet setup with various food items, a modern chandelier, and a patterned floor.

16. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (338 reviews)
"Great location."
United States
George S
The price is ₩84,420
₩94,872 total
Sep 25 - Sep 26
Ibis Styles El Malecon Guayaquil
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

17. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ₩107,200
₩119,930 total
Sep 18 - Sep 19
Courtyard by Marriott Guayaquil
A hotel room with two beds, a TV, a painting, and a desk.

18. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.8 out of 10, Excellent, (47 reviews)
"Breakfast was amazing! I loved everything about it!"
United States
Josue
The price is ₩40,859
₩42,199 total
Sep 12 - Sep 13
Hotel GH Alexander
A breakfast table with various foods and a view of a park through a window.

19. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Excellent hotel"
United States
Monica
The price is ₩100,500
₩113,900 total
Sep 26 - Sep 27
Unipark by Oro Verde Hotels
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

20. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (732 reviews)
"The pool was truly wonderful, offering beautiful views and the perfect water temperature. The food was exceptional as well, and the staff were incredibly helpful."
United States
Yoan
The price is ₩103,264
₩116,965 total
Sep 12 - Sep 13
Radisson Hotel Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Moorish Clock Tower while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Policentro.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Hilton Colon Guayaquil

Hilton Colon Guayaquil

10/10 Excellent
"Excelente"
SABRINA 2-night trip
Posted 2 hours ago
Hilton Colon Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 90 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.