A densely packed urban area with numerous buildings and a prominent tower on a hill.

Find hotels in Puerto Santa Ana, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,006 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ₩156,487
₩175,532 total
Sep 13 - Sep 14
Wyndham Guayaquil Puerto Santa Ana
A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (109 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ₩116,061
₩117,419 total
Sep 6 - Sep 7
Luxury Suites Riverfront GYE
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (62 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₩145,485
₩160,427 total
Sep 5 - Sep 6
River View suites Puerto Santa Ana gye
A cocktail on a marble table with a pool in the background.

4. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very Good, (163 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ₩60,191
₩61,549 total
Sep 23 - Sep 24
Hotel Patrimonial by Greenfield
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

5. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (950 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ₩87,916
₩98,746 total
Sep 6 - Sep 7
Hotel Palace Guayaquil
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

6. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (146 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ₩80,689
₩90,116 total
Sep 10 - Sep 11
Mansión del Río
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

7. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,005 reviews)
"Good service but just inconsistent Internet/wi-fi. Beautiful hotel."
United States
Maria
The price is ₩91,937
₩103,169 total
Oct 3 - Oct 4
Grand Hotel Guayaquil, Centro Histórico.
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

8. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very Good, (410 reviews)
"Love the area where the hotel is located. Excellent breakfast. The pool area is beautiful where you can seat and relax "
United States
Sixto
The price is ₩85,580
₩86,938 total
Sep 27 - Sep 28
Hotel Ramada
A breakfast table with various foods and a view of a park through a window.

9. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,011 reviews)
"Excellent hotel"
United States
Monica
The price is ₩96,786
₩109,861 total
Sep 27 - Sep 28
Unipark by Oro Verde Hotels

10. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (655 reviews)
"Nice, clean simple, family run hotel with good transportation."
United States
Gerald
The price is ₩48,902
₩50,260 total
Sep 5 - Sep 6
DC Suites Aeropuerto
A hotel room with a bed, a nightstand, a desk, a chair, and a window with curtains.

11. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very Good, (122 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ₩40,752
₩42,110 total
Sep 29 - Sep 30
Hotel Las Peñas
A wooden bedside table with a remote control, a lamp, and a power outlet.

12. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (336 reviews)
"Great location."
United States
George S
The price is ₩81,510
₩91,699 total
Sep 5 - Sep 6
Ibis Styles El Malecon Guayaquil
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

13. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Good staff, excelent food. I will defenetly will come back"
United States
Gloria E
The price is ₩108,672
₩121,577 total
Sep 11 - Sep 12
Courtyard by Marriott Guayaquil
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

14. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ₩108,808
₩121,726 total
Sep 12 - Sep 13
Wyndham Garden Guayaquil
A hotel room with two beds, a TV, a painting, and a desk.

15. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.6 out of 10, Excellent, (45 reviews)
"Great value hot water clean friendly staff on site restaurant "
United States
Monty
The price is ₩41,421
₩42,779 total
Sep 5 - Sep 6
Hotel GH Alexander
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

16. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₩456,422
₩507,837 total
Sep 14 - Sep 15
Hotel Río Guayas by Art Hotels Ecuador
A building with a traditional architectural style, featuring a prominent entrance with a set of stairs leading up to a double door.

17. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 3.5 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (181 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ₩130,814
₩132,172 total
Sep 6 - Sep 7
Luxva Hotel Boutique
A hotel with a modern facade, featuring a prominent vertical light installation.

18. Hotel Sada

Hotel Sada
3.0 star property
Roca, 1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ₩62,989
₩64,347 total
Sep 5 - Sep 6
Hotel Sada
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

19. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,001 reviews)
"Great breakfast, friendly and helpful staff."
United States
VICENTE
The price is ₩124,973
₩140,866 total
Sep 18 - Sep 19
Oro Verde Guayaquil
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

20. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (729 reviews)
"Great property"
United States
Joseph
The price is ₩120,898
₩136,384 total
Sep 6 - Sep 7
Radisson Hotel Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

An iguana on green grass.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Central Market while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Policentro.

A golden statue of two figures forming a heart shape on a paved area with a modern building in the background.
Photo by Botak Jon
Open Photo by Botak Jon

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport

10/10 Excellent
"👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍"
MARLON G 2-night trip
Posted 7 hours ago
Hotel Puerto Pacifico Guayaquil Airport

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 90 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.