A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Sep 25 - Sep 27
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Oct 2 - Oct 4

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ₩147,447
₩165,605 total
Sep 26 - Sep 27
Wyndham Guayaquil Puerto Santa Ana
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (65 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₩146,218
₩147,583 total
Oct 1 - Oct 2
River View suites Puerto Santa Ana gye
A cocktail on a marble table with a pool in the background.

3. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (165 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ₩60,526
₩61,892 total
Sep 26 - Sep 27
Hotel Patrimonial by Greenfield
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ₩81,096
₩90,571 total
Oct 4 - Oct 5
Mansión del Río
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

5. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (956 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ₩88,358
₩99,242 total
Oct 4 - Oct 5
Hotel Palace Guayaquil
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

6. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,009 reviews)
"Nice breakfast setup the pool was fantastic and the room very spacious location was perfect next to everything"
United States
Edwin
The price is ₩98,350
₩110,234 total
Oct 24 - Oct 25
Grand Hotel Guayaquil, Centro Histórico.
A hotel room with a bed, a nightstand, a desk, a chair, and a window with curtains.

7. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very good, (124 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ₩36,862
₩38,227 total
Oct 1 - Oct 2
Hotel Las Peñas
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

8. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₩447,169
₩497,691 total
Sep 26 - Sep 27
Hotel Río Guayas by Art Hotels Ecuador

9. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (661 reviews)
"The hotel was very nice and a very helpful staff. Easy on the eyes too."
Canada
Jeff
The price is ₩49,175
₩50,541 total
Sep 26 - Sep 27
DC Suites Aeropuerto
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

10. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (412 reviews)
"👍"
United States
Washington
The price is ₩86,011
₩87,376 total
Sep 27 - Sep 28
Hotel Ramada
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

11. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ₩109,220
₩122,190 total
Oct 4 - Oct 5
Courtyard by Marriott Guayaquil
A hotel with a modern facade, featuring a prominent vertical light installation.

12. Hotel Sada

Hotel Sada
3.0 star property
1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ₩63,307
₩64,672 total
Oct 1 - Oct 2
Hotel Sada
A breakfast table with various foods and a view of a park through a window.

13. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean hospitality excellent place to stay. Would come again ."
United States
silvia
The price is ₩102,516
₩116,183 total
Oct 17 - Oct 18
Unipark by Oro Verde Hotels
A hotel room with two beds, a TV, a painting, and a desk.

14. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.8 out of 10, Excellent, (49 reviews)
"Breakfast was amazing! I loved everything about it!"
United States
Josue
The price is ₩41,651
₩43,017 total
Oct 1 - Oct 2
Hotel GH Alexander
A buffet setup with various food items, a modern chandelier, and a patterned floor.

15. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (340 reviews)
"Clean, safe & secure facilities with friendly and accommodating staff. Rooms were decent size/layout, with very comfortable bedding, The food at the hotel is a little pricey but excellent, as is the location - steps away from other outstanding local restaurants."
United States
Carmen
The price is ₩86,011
₩96,660 total
Sep 26 - Sep 27
Ibis Styles El Malecon Guayaquil
A modern lobby with large windows, a staircase, and comfortable seating areas.

16. Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (127 reviews)
"Good staff...great location"
United States
ALBERTO
The price is ₩104,436
₩133,529 total
Oct 4 - Oct 5
Doubletree By Hilton Guayaquil
A modern hotel room with a bed, bedside table, and a desk with a chair.

17. Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
8.2 out of 10, Very good, (83 reviews)
"Overall a good place to stay and close to most destinations."
United States
Daniel
The price is ₩34,422
₩35,788 total
Sep 28 - Sep 29
Hotel Varadero Internacional
A building with a traditional architectural style, featuring a prominent entrance with a set of stairs leading up to a double door.

18. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 3.5 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (182 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ₩143,761
₩145,126 total
Oct 5 - Oct 6
Luxva Hotel Boutique
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

19. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (737 reviews)
"The pool was truly wonderful, offering beautiful views and the perfect water temperature. The food was exceptional as well, and the staff were incredibly helpful."
United States
Yoan
The price is ₩109,220
₩123,555 total
Oct 4 - Oct 5
Radisson Hotel Guayaquil
An outdoor seating area with wicker chairs and a table, a glass wall with a reflection, and hanging orange lights.

20. Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 3.7 km from Puerto Santa Ana
8.8 out of 10, Excellent, (287 reviews)
"The staff was very nice and helpful, the room was very clean along with their good smelling towels. Area seemed very safe."
United States
Diana
The price is ₩85,196
₩95,769 total
Oct 25 - Oct 26
Hotel Puerto Pacifico Guayaquil Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to Alban Borja Commercial Center or San Marino Mall.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

10/10 Excellent
"Excelente servicio. Personal muy amable y atento. Experiencia sobresaliente."
Antonio 1-night trip
Posted 8 hours ago
Unipark by Oro Verde Hotels

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 89 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.