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Our top choices for Puerto Santa Ana hotels

A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is ₩147,537
₩165,650 total
Nov 29 - Nov 30
Wyndham Guayaquil Puerto Santa Ana
A laptop on a glass table with a plate of food and a chair in a room with a view of the sea.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (67 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₩105,211
₩119,992 total
Nov 8 - Nov 9
River View suites Puerto Santa Ana gye
A rooftop pool with a view of the city skyline.

3. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (112 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ₩114,804
₩116,148 total
Nov 19 - Nov 20
Luxury Suites Riverfront GYE
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is ₩71,612
₩80,117 total
Nov 5 - Nov 6
Mansión del Río
A rooftop pool with a curved edge, lounge chairs, and potted plants.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₩399,076
₩444,695 total
Nov 16 - Nov 17
Hotel Río Guayas by Art Hotels Ecuador
A hot tub surrounded by palm trees and a brick wall, with a metal railing in the foreground.

6. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ₩107,495
₩120,260 total
Nov 7 - Nov 8
Wyndham Garden Guayaquil
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

7. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (422 reviews)
"Excelente atención, good service, sauna and pull in great condition, food very good"
United States
Pedro
The price is ₩84,649
₩85,993 total
Nov 8 - Nov 9
Hotel Ramada
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

8. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Very friendly staff, excellent breakfast, maintained and modern rooms. Was a great stay."
United States
ricardo
The price is ₩122,276
₩137,863 total
Nov 8 - Nov 9
Oro Verde Guayaquil
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

9. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,006 reviews)
"Great service"
United States
Rene
The price is ₩133,630
₩150,352 total
Nov 22 - Nov 23
Hilton Colon Guayaquil
A swimming pool with a tiled deck, surrounded by buildings with large windows and a balcony.

10. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (169 reviews)
"Was ok"
United States
Juan
The price is ₩54,258
₩55,602 total
Nov 5 - Nov 6
Hotel Patrimonial by Greenfield
An indoor pool with a waterfall, surrounded by lush tropical plants.

11. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is ₩101,045
₩113,166 total
Nov 28 - Nov 29
Grand Hotel Guayaquil, Centro Histórico.
A modern building with the Fortune Hotel sign, featuring a flat facade, large windows, and a gated entrance.

12. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
8.0 out of 10, Very good, (12 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ₩66,513
₩67,857 total
Nov 12 - Nov 13
Fortune Hotel
A person sitting by a window with a towel on their head, reading a magazine.

13. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,005 reviews)
"Clean room, professional staff, delicious breakfast."
United States
Iris
The price is ₩135,713
₩152,643 total
Nov 14 - Nov 15
Holiday Inn Guayaquil Airport by IHG
A reception desk with a marble top and a modern light fixture above it.

14. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,008 reviews)
"Convenient near airport."
United States
MIGUEL A.
The price is ₩120,932
₩136,384 total
Nov 22 - Nov 23
TRYP by Wyndham Guayaquil Airport
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

15. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ₩102,792
₩115,088 total
Nov 14 - Nov 15
Courtyard by Marriott Guayaquil
An outdoor seating area with tables and chairs, potted plants, and a view of trees through large windows.

16. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (359 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is ₩80,621
₩90,699 total
Dec 4 - Dec 5
Ibis Styles El Malecon Guayaquil
A modern living room with a sectional sofa, a yellow armchair, and a wooden coffee table.

17. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (759 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is ₩114,214
₩128,994 total
Nov 7 - Nov 8
Radisson Hotel Guayaquil
A spacious living area with a sectional sofa, a round coffee table, and a large vase. There is a view of trees through the windows.

18. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Great for a short stay"
United States
Maria
The price is ₩82,973
₩94,636 total
Nov 20 - Nov 21
Unipark by Oro Verde Hotels
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

19. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (967 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is ₩77,385
₩87,139 total
Nov 14 - Nov 15
Hotel Palace Guayaquil
A rooftop pool with lounge chairs and umbrellas, surrounded by greenery and a multi-level parking garage in the background.

20. Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 2.9 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (694 reviews)
"Clean room, nice hotel"
United States
John
The price is ₩130,069
₩146,435 total
Nov 14 - Nov 15
Sheraton Guayaquil Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Puerto Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.
Wyndham Guayaquil Puerto Santa Ana
4.5 star property
9.4
Exceptional
1,003 reviews
View
A rooftop pool with a view of the city skyline.
Luxury Suites Riverfront GYE
3.5 star property
9.4
Exceptional
112 reviews
View
A laptop on a glass table with a plate of food and a chair in a room with a view of the sea.
River View suites Puerto Santa Ana gye
3.0 star property
9.0
Wonderful
67 reviews
View
A rooftop pool with a curved edge, lounge chairs, and potted plants.
Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
10.0
Exceptional
5 reviews
View
A hotel with a modern facade, featuring a prominent vertical light installation.
Hotel Sada
3.0 star property
9.8
Exceptional
12 reviews
View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

A rooftop pool with a curved edge, lounge chairs, and potted plants.
Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
Las Peñas

10/10 Excellent

Outstanding staff - great property
United States
septimiu
Reviewed August 28, 2026
Hotel Río Guayas by Art Hotels Ecuador

Frequently Asked Questions

What's it like in Puerto Santa Ana?

Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.

Where is the best hotel for a stay in Puerto Santa Ana?

Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.

How many hotels will I find in Puerto Santa Ana?

If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.

Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?

To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.

What is there to do around this Guayaquil neighborhood?

Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.