A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Check prices for these dates

Next weekend
Sep 11 - Sep 13
In two weeks
Sep 18 - Sep 20

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Our top choices for Puerto Santa Ana hotels

Bar (on property)

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,006 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ₩155,075
₩173,948 total
Sep 13 - Sep 14
Wyndham Guayaquil Puerto Santa Ana
Outdoor spa tub

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (109 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ₩115,014
₩116,360 total
Sep 12 - Sep 13
Luxury Suites Riverfront GYE
Rooftop terrace

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (63 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₩144,172
₩145,518 total
Sep 7 - Sep 8
River View suites Puerto Santa Ana gye
Food and drink

4. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very Good, (163 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ₩59,647
₩60,993 total
Sep 7 - Sep 8
Hotel Patrimonial by Greenfield
Lobby

5. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (950 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ₩87,122
₩97,853 total
Sep 12 - Sep 13
Hotel Palace Guayaquil
Lobby lounge

6. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ₩79,960
₩89,302 total
Sep 7 - Sep 8
Mansión del Río
Pool

7. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,006 reviews)
"Pool is surrounded by the dining area, it made it more a chill space than lounge. The hotel great service, very accommodating and noticeable security around the premises"
United States
tahiane
The price is ₩101,230
₩113,372 total
Sep 27 - Sep 28
Grand Hotel Guayaquil, Centro Histórico.
Indoor pool

8. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very Good, (410 reviews)
"Love the area where the hotel is located. Excellent breakfast. The pool area is beautiful where you can seat and relax "
United States
Sixto
The price is ₩84,807
₩86,153 total
Sep 7 - Sep 8
Hotel Ramada
Breakfast meal

9. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,012 reviews)
"Excellent hotel"
United States
Monica
The price is ₩95,912
₩108,875 total
Sep 26 - Sep 27
Unipark by Oro Verde Hotels
Property entrance

10. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (655 reviews)
"Nice, clean simple, family run hotel with good transportation."
United States
Gerald
The price is ₩48,461
₩49,807 total
Sep 7 - Sep 8
DC Suites Aeropuerto
Room

11. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very Good, (122 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ₩36,346
₩37,692 total
Sep 19 - Sep 20
Hotel Las Peñas
Restaurant

12. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (336 reviews)
"Great location."
United States
George S
The price is ₩84,807
₩95,307 total
Sep 12 - Sep 13
Ibis Styles El Malecon Guayaquil
Lobby

13. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Good staff, excelent food. I will defenetly will come back"
United States
Gloria E
The price is ₩107,691
₩120,479 total
Sep 11 - Sep 12
Courtyard by Marriott Guayaquil
Bar (on property)

14. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ₩107,825
₩120,627 total
Sep 12 - Sep 13
Wyndham Garden Guayaquil
Comfort Double Room

15. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.8 out of 10, Excellent, (47 reviews)
"Breakfast was amazing! I loved everything about it!"
United States
Josue
The price is ₩41,047
₩42,393 total
Sep 7 - Sep 8
Hotel GH Alexander
Room

16. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₩452,303
₩503,254 total
Sep 7 - Sep 8
Hotel Río Guayas by Art Hotels Ecuador
Front of property

17. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 3.5 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (181 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ₩129,633
₩130,979 total
Sep 7 - Sep 8
Luxva Hotel Boutique
Front of property

18. Hotel Sada

Hotel Sada
3.0 star property
Roca, 1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ₩62,421
₩63,767 total
Sep 7 - Sep 8
Hotel Sada
Children's activities

19. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,002 reviews)
"Very nice stay"
United States
Freddy
The price is ₩123,845
₩139,594 total
Sep 18 - Sep 19
Oro Verde Guayaquil
Property entrance

20. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (730 reviews)
"Great property"
United States
Joseph
The price is ₩119,806
₩135,152 total
Sep 13 - Sep 14
Radisson Hotel Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

An iguana on green grass.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Moorish Clock Tower while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Policentro.

A golden statue of two figures forming a heart shape on a paved area with a modern building in the background.
Photo by Botak Jon
Open Photo by Botak Jon

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Radisson Hotel Guayaquil

Radisson Hotel Guayaquil

10/10 Excellent
"The pool was truly wonderful, offering beautiful views and the perfect water temperature. The food was exceptional as well, and the staff were incredibly helpful."
Yoan 1-night trip
Posted 8 hours ago
Radisson Hotel Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 90 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.