Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southern Illinois Hotels

La Quinta Inn & Suites by Wyndham Effingham

1103 Avenue Of Mid America Effingham IL

4 hours drive from Southern Illinois University

This pet-friendly hotel welcomes dogs and cats (fees apply).

9.2/10 Wonderful! (1,002 reviews)

Always a nice clean room.

Reviewed on Dec 12, 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

This pet-friendly hotel welcomes dogs and cats (fees apply).

5.8/10 (1,002 reviews)

Clean bed and room. Very nice staff

Reviewed on Dec 12, 2025

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.6/10 Good! (1,000 reviews)

Would have liked a better variety for breakfast but overall stay was great.

Reviewed on Nov 25, 2025

See all 1,112 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.