Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southern Illinois Hotels

La Quinta Inn & Suites by Wyndham Effingham

1103 Avenue Of Mid America Effingham IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

9.2/10 Wonderful! (1,001 reviews)

Clean rooms and lobby space. The breakfast had lots of options, and in the afternoon the lobby also offered cookies and popcorn.

Reviewed on Mar 23, 2026

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

6/10 (1,003 reviews)

Found roaches in the bathroom

Reviewed on Mar 26, 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

4 hours drive from Shawnee National Forest

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.8/10 Good! (1,000 reviews)

Not very clean

Reviewed on Mar 25, 2026

See all 1,172 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.