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Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Candy

₩201,392 total

includes taxes & fees

Aug 20 - Aug 21

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Cecil

₩168,749 total

includes taxes & fees

Aug 16 - Aug 17

3. Comfort Suites Mount Vernon

Mount Vernon

Lee

₩191,476 total

includes taxes & fees

Aug 30 - Aug 31

4. Cobblestone Inn & Suites - Altamont

Altamont

William

₩154,200 total

includes taxes & fees

Aug 9 - Aug 10

5. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Anne-Marie

₩152,973 total

includes taxes & fees

Aug 2 - Aug 3

In-room safe, desk, iron/ironing board, cribs (surcharge)

6. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

John

₩107,532 total

includes taxes & fees

Aug 9 - Aug 10

7. Best Western Delta Inn

Effingham

Roger

₩159,281 total

includes taxes & fees

Aug 10 - Aug 11

8. Suite Dreams Hotel

Mattoon

Judd

₩153,464 total

includes taxes & fees

Aug 1 - Aug 2

9. Hampton Inn & Suites Effingham

Effingham

Kate

₩223,004 total

includes taxes & fees

Aug 14 - Aug 15

10. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Samuel

₩222,348 total

includes taxes & fees

Aug 9 - Aug 10

Desk, laptop workspace, blackout drapes, iron/ironing board

11. Baymont by Wyndham Effingham

Effingham

Amy

₩115,673 total

includes taxes & fees

Aug 18 - Aug 19

12. Holiday Inn Express Metropolis by IHG

Metropolis

James

₩147,938 total

includes taxes & fees

Aug 13 - Aug 14

13. Best Western Plus Parkside Inn & Suites

Olney

Brenda

₩202,766 total

includes taxes & fees

Aug 20 - Aug 21

14. Holiday Inn Effingham by IHG

Effingham

Parry

₩153,782 total

includes taxes & fees

Aug 20 - Aug 21

15. Super 8 by Wyndham Troy IL/St. Louis Area

Troy

Donta

₩134,724 total

includes taxes & fees

Aug 11 - Aug 12

Iron/ironing board, WiFi (free), bed sheets

16. Quality Inn & Suites Metropolis I-24

Metropolis

Howard

₩109,258 total

includes taxes & fees

Aug 2 - Aug 3

17. La Quinta Inn & Suites by Wyndham Effingham

Effingham

michael

₩166,147 total

includes taxes & fees

Aug 16 - Aug 17

18. Drury Inn & Suites Marion

Marion

Claudia

₩173,069 total

includes taxes & fees

Aug 9 - Aug 10

19. The Principal Hotel

Columbia

Bounma

₩180,614 total

includes taxes & fees

Aug 2 - Aug 3

20. Best Western Marion Hotel

Marion

Lauren

₩154,702 total

includes taxes & fees

Aug 11 - Aug 12

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Vacation Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Vacation Home

Villa, 4 Bedrooms | Private kitchen | Coffee/tea maker, fridge, oven

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

The Principal Hotel

8/10 Good

"The Principal Hotel is a jewel. Accommodations were very adequate. The staff was super friendly and the surrounding area was quaint. My issues are the room needed a little more cleaning, i.e. lots of hair left in the sofa bed along with food crumbs and Carmex. Next, a fan was constantly running and could not be turned off so the room was mostly always freezing for us. The space was large and more then enough room for everyone."

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"Pool was so much fun and my daughter’s birthday was recognized by the staff when we checked in that was so nice! Also I thought I left something in the room the staff went above and beyond to look for our missing item. We also enjoyed the drinks in the evening."

Ramada by Wyndham Effingham

8/10 Good

"The room was clean. The staff was excellent. I like the location. It diminishes the traffic noise. Nice hiking trail nearby. I love the fact that they are dog friendly. Only a couple of minor issues: The thermostat on the A/C unit did not work. No matter how high I set the temperature, the unit never shut off. No problem. I just turned it on and off manually. The tub could be replaced. It was functional, but it did not look too nice. Not a problem for me, but some guests might not like that."