Southern Illinois Pet-friendly Vacations
Book a Pet-friendly Hotel + Flight or Car together to unlock savings
Photo by Southernmost Illinois Tourism Bureau
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Save up to ₩234,741 when you book a flight and hotel together*
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Top Pet-friendly Southern Illinois Hotels
La Quinta Inn & Suites by Wyndham Effingham
1103 Avenue Of Mid America, Effingham, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
9/10 Wonderful! (1,008 reviews)
"Nice stay"
Reviewed on Jul 2, 2025
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
136 Regency Park, O'Fallon, IL
This pet-friendly hotel welcomes dogs and cats (fees apply).
6.2/10 (1,002 reviews)
Honest review
"Room was clean and everything else. However the smell when you go through those doors are not the best, stink really bad."
Reviewed on Jun 30, 2025
Red Roof Inn St Louis - Troy, IL
2030 Formosa Road, Troy, IL
Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.
7.6/10 Good! (1,002 reviews)
"I wish they had a hot breakfast, with waffles. Other than that it was a great stay!!"
Reviewed on Jul 4, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.