A street lined with historic buildings, palm trees, and a church tower with a clock.

Find Business Hotels in Daniel Island, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Daniel Island Business Hotels

Tonight
Oct 5 - Oct 6
Tomorrow
Oct 6 - Oct 7
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Our top choices for Daniel Island business-friendly hotels

An outdoor patio area with a fire pit, seating, and a covered section.
A modern hotel room with a kitchenette, a bed, a desk, and a television.
A modern breakfast bar with a 'GOOD MORNING' sign, a 'inspired table' sign, and various breakfast items and appliances.
A modern kitchen area with a coffee station featuring three coffee makers labeled 'GOURMET,' 'DECAF,' and 'HOT WATER.' There is a stone pillar and a sign on the wall that reads 'HOMER.'

1. Home2 Suites by Hilton Charleston Daniel Island

Home2 Suites by Hilton Charleston Daniel Island
Charleston
United States
Layla
₩183,814
₩209,550 total
includes taxes & fees
Nov 1 - Nov 2
Home2 Suites by Hilton Charleston Daniel Island
A covered outdoor area with a pool, palm trees, and lounge chairs.
A spacious lobby with high ceilings, a grand chandelier, and a central open area leading to a door.
A spacious restaurant with high ceilings, exposed beams, and a brick fireplace. Tables are arranged in a U-shape around the fireplace, with hanging pendant lights above.
A covered outdoor lounge area with wicker furniture, a pool, and a view of the beach and marina.

2. The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina
Mount Pleasant
United States
Lane
₩220,151
₩312,384 total
includes taxes & fees
Oct 25 - Oct 26
The Beach Club at Charleston Harbor Resort and Marina
A pool area with lounge chairs and palm trees.
A modern restaurant with a long counter, multiple dining tables, and a seating area with sofas.
A modern kitchen with a central island, built-in shelves, and a variety of kitchen appliances.
A paved pathway leading to a building with large trees and hanging moss.

3. Hotel Indigo Mount Pleasant by IHG

Hotel Indigo Mount Pleasant by IHG
Mount Pleasant
United States
Linda C
₩120,765
₩163,255 total
includes taxes & fees
Nov 2 - Nov 3
Hotel Indigo Mount Pleasant by IHG
A swimming pool with lounge chairs and umbrellas, surrounded by trees and a building with multiple windows.
A hotel lobby with a buffet area, seating arrangements, and a large plant.
A hotel room with a sofa, two beds, a desk, and a window with a view.
A modern living room with a sectional sofa, a coffee table, a chair, and a flat-screen TV mounted on the wall.

4. Holiday Inn Express & Suites Mt. Pleasant by IHG

Holiday Inn Express & Suites Mt. Pleasant by IHG
Mount Pleasant
United States
Tami
₩148,778
₩171,175 total
includes taxes & fees
Oct 8 - Oct 9
Holiday Inn Express & Suites Mt. Pleasant by IHG
A modern bar area with a wooden ceiling, bar stools, and a counter.
A gym with treadmills, weight machines, and a mirror.
A modern lounge area with a black sofa, wooden stools, and contemporary chairs.
A modern kitchen with a Keurig coffee maker, a coffee station, a large mirror, and artwork on the wall.

5. Cambria Hotel Mount Pleasant – Charleston

Cambria Hotel Mount Pleasant – Charleston
Mount Pleasant
United States
Fred V.
₩163,950
₩186,547 total
includes taxes & fees
Oct 28 - Oct 29
Cambria Hotel Mount Pleasant – Charleston
A bar area with a curved counter, multiple seating options including round tables and chairs, and a patterned floor.
A lobby with a central seating area, a chandelier, and framed pictures on the walls.
A hallway with a patterned carpet, a modern chandelier, and an elevator.
A modern hotel lobby with a round seating area, a chandelier, and a patterned floor.

6. DoubleTree by Hilton Charleston Mount Pleasant

DoubleTree by Hilton Charleston Mount Pleasant
Mount Pleasant
United States
Paul
₩151,324
₩173,678 total
includes taxes & fees
Nov 4 - Nov 5
DoubleTree by Hilton Charleston Mount Pleasant
A modern lobby with seating areas, a reception desk, and decorative lighting.
A multi-story hotel with a modern design, featuring a parking lot and landscaped areas.
A modern hotel with a pool, surrounded by trees and a sunset sky.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view of trees.

7. Tru by Hilton Mt Pleasant Charleston

Tru by Hilton Mt Pleasant Charleston
Mount Pleasant
United States
FELECIA
₩146,968
₩168,757 total
includes taxes & fees
Oct 18 - Oct 19
Tru by Hilton Mt Pleasant Charleston
A grand lobby with a central round table, seating, and potted plants.
A grand lobby with a large chandelier, a wooden cabinet with glass doors, and a patterned carpet.
A grand hallway with a patterned floor, chandeliers, and seating areas.
A spacious lobby with a grand piano, elegant chandeliers, and plush seating areas.

8. The Francis Marion Hotel

The Francis Marion Hotel
Charleston Historic District
United States
Brady
₩288,307
₩328,665 total
includes taxes & fees
Nov 1 - Nov 2
The Francis Marion Hotel
A hotel lobby with a bar area, multiple dining tables, and chairs.
A gym with treadmills, elliptical machines, and an ICG stationary bike, large windows, and a clock on the wall.
A modern kitchen with a central island, bar stools, and a variety of kitchen appliances.
A spacious lobby with a high ceiling, a staircase with a wooden handrail, and a seating area with patterned cushions.

9. Hilton Garden Inn Charleston / Mt. Pleasant

Hilton Garden Inn Charleston / Mt. Pleasant
Mount Pleasant
United States
Susan
₩169,767
₩191,836 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn Charleston / Mt. Pleasant
A modern kitchen with a large island, bar stools, framed pictures on the wall, and a view of the outside.
A hotel room with a bed, desk, chair, television, and a mirror.
A hotel with a swimming pool, outdoor seating, and a gazebo.
A modern hotel lobby with a gray sofa, a wooden coffee table, and a patterned rug.

10. Quality Inn Mt. Pleasant - Charleston

Quality Inn Mt. Pleasant - Charleston
Mount Pleasant
United States
Lori
₩117,802
₩135,797 total
includes taxes & fees
Nov 3 - Nov 4
Quality Inn Mt. Pleasant - Charleston
View all properties

Top Daniel Island Hotel Reviews

Drury Plaza Hotel North Charleston

Drury Plaza Hotel North Charleston

10/10 Excellent
"Everything was Great!!! I will be coming back to stay."
Robert 2-night trip
Posted 2 hours ago
Drury Plaza Hotel North Charleston
Tides Folly Beach, Charleston's Oceanfront Hotel

Tides Folly Beach, Charleston's Oceanfront Hotel

10/10 Excellent
"Fri T desk very helpful. Literally in the beach n on premise bar was fun"
Peter 2-night trip
Posted 6 hours ago
Tides Folly Beach, Charleston's Oceanfront Hotel
Hotel Indigo Mount Pleasant by IHG

Hotel Indigo Mount Pleasant by IHG

10/10 Excellent
"Hotel is beautiful and clean. I would definitely stay there again."
Althea 3-night trip
Posted 7 hours ago
Hotel Indigo Mount Pleasant by IHG
The Francis Marion Hotel

The Francis Marion Hotel

10/10 Excellent
"Tom was an amazing and looked after me at Valet and the front desk."
Stuart 1-night trip
Posted 7 hours ago
The Francis Marion Hotel
The Vendue

The Vendue

10/10 Excellent
"The staff were welcoming and kind. The complimentary breakfast each morning was a nice touch. Great location. We would definitely come back again!"
Monica 3-night trip
Posted 10 hours ago
The Vendue
The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina

10/10 Excellent
"Beautiful rooms, large bathroom, Beautifully decorated, lovely pools, all around a great hotel!"
Lane 1-night trip
Posted 1 day ago
The Beach Club at Charleston Harbor Resort and Marina

Frequently asked questions

Why book your business-friendly hotel in Daniel Island with Expedia?
With amenities like conference rooms, housekeeping and on-site restaurants, our business-friendly properties come with all you'll need to settle that big contract — and then put your feet up! Enter your preferred travel dates and destination and Expedia will help you plan the rest.
How can I find cheap business-friendly hotels in Daniel Island?
When work takes you on the road in Daniel Island, our "business friendly" filter will help you find the right hotel. From free WiFi to conference spaces and in-room desks, they have the amenities you need to be productive. You can also narrow your search by your preferred star rating and budget to view the most affordable accommodations.

Explore a world of travel with Expedia