A cannon on a brick platform by a river, with a steamboat in the background.

Find hotels in New Madrid, MO from ₩73,948

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Sep 8 - Sep 9
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Sep 9 - Sep 10
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

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Our top choices for New Madrid hotels

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A kitchenette with a coffee machine, a kettle, and storage shelves.
An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.
A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

1. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
₩142,623
₩161,485 total
includes taxes & fees
Oct 9 - Oct 10
Holiday Inn Express & Suites Sikeston Southwest by IHG
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

2. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
₩135,896
₩153,870 total
includes taxes & fees
Sep 17 - Sep 18
Fairfield Inn & Suites by Marriott Sikeston
A hotel room with a dark wooden desk, a television, a lamp, a chair, and a mirror on the wall.
A bathroom with a bathtub, a toilet, and a sink.
A building with multiple floors and a flat roof, surrounded by a grassy area with trees.
A parking lot with a grassy area and trees in the background.

3. Reelfoot Lake Inn

Reelfoot Lake Inn
Tiptonville
United States
Larry
₩82,076
₩94,182 total
includes taxes & fees
Oct 6 - Oct 7
Reelfoot Lake Inn
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.
An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

4. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
Jeffrey
₩136,810
₩154,903 total
includes taxes & fees
Sep 20 - Sep 21
Hampton Inn Sikeston
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.
A modern kitchen with a marble countertop, a red accent wall, and a black and yellow logo on the floor mat.

5. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Rachel
₩90,095
₩102,912 total
includes taxes & fees
Oct 1 - Oct 2
Super 8 By Wyndham Marston
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

6. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Lauren
₩158,769
₩179,768 total
includes taxes & fees
Sep 17 - Sep 18
TownePlace Suites by Marriott Sikeston
A hotel room with two beds, a television, a desk, and a mirror.
A bathroom with a sink, mirror, and chair.
A hotel room with a dining area, a sofa, and a kitchen counter with appliances.
A hotel room with a bed, a desk, a television, and a seating area with a small table.

7. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
Marston
United States
Frank
₩64,745
₩73,948 total
includes taxes & fees
Sep 16 - Sep 17
Travel Inn Marston I-55 by Hotel O
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Stay near popular New Madrid attractions

Hunter-Dawson State Historic Site

7.6/10 (13 reviews)
Step back in time at this antebellum mansion with 80% of its original furnishings intact. Explore nine fireplaces and period decor through guided tours of the 15-room Hunter-Dawson House.
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New Madrid Historical Museum

8.2/10 (36 reviews)
Explore the powerful 1811-1812 earthquakes that reshaped America's heartland at this historic museum. Engage with knowledgeable curators while viewing artifacts from Native American cultures and the Civil War.
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River Ridge Winery

8.4/10 (15 reviews)
Sip handcrafted wines in a century-old farmhouse atop the Mississippi River hills. Wander through estate vineyards or enjoy fresh meals on the scenic grounds of this Missouri wine destination.
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Learn more about New Madrid

The New Madrid Historical Museum reveals the dramatic story of the 1811-1812 earthquakes that changed the course of the Mississippi River. Enjoy peaceful fishing at Donaldson Point Conservation Area or take a sunset river cruise to spot bald eagles along the mighty Mississippi.

See all hotels in New Madrid
A cannon on a brick platform by a river, with a steamboat in the background.

Top New Madrid Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Really quiet place close to good restaurants and stores."
james 1-night trip
Posted 5 hours ago
Hampton Inn Sikeston
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

10/10 Excellent
"Great location"
Rubin 2-night trip
Posted 18 hours ago
TownePlace Suites by Marriott Sikeston
Reelfoot Lake Inn

Reelfoot Lake Inn

10/10 Excellent
"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"
Larry 4-night trip
Posted 10 days ago
Reelfoot Lake Inn
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

10/10 Excellent
"they were very nice and my room was close to my car"
Rachel 1-night trip
Posted 3 weeks ago
Super 8 By Wyndham Marston
Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O

8/10 Good
"Worked for the price. Room was clean. Staff was friendly! "
Alicia 1-night trip
Posted 4 months ago
Travel Inn Marston I-55 by Hotel O

More cheap stays in New Madrid

Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O

301 Route Ad Marston MO
₩64,745
₩73,948 total
Sep 16 - Sep 17
includes taxes & fees
5.8/10 (129 reviews)
Travel Inn Marston I-55 by Hotel O
Reelfoot Lake Inn

Reelfoot Lake Inn

1520 State Route 21 East Tiptonville TN
₩82,076
₩94,182 total
Oct 6 - Oct 7
includes taxes & fees
7.2/10 Good! (504 reviews)
Reelfoot Lake Inn
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

501 S Outer Road Marston MO
₩90,095
₩102,912 total
Oct 1 - Oct 2
includes taxes & fees
8/10 Very Good! (72 reviews)
Super 8 By Wyndham Marston
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
₩136,810
₩154,903 total
Sep 20 - Sep 21
includes taxes & fees
9/10 Wonderful! (621 reviews)
Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO
₩142,623
₩161,485 total
Oct 9 - Oct 10
includes taxes & fees
Holiday Inn Express & Suites Sikeston Southwest by IHG
New Orleans Inn Portageville

New Orleans Inn Portageville

600 US-61 Portageville MO
Get rates
8/10 Very Good! (797 reviews)
New Orleans Inn Portageville

Frequently asked questions

Where is the best place for a stay in New Madrid?
Hampton Inn Sikeston, located 18.9 mi (30.4 km) from the heart of New Madrid, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Holiday Inn Express & Suites Sikeston Southwest by IHG and Fairfield Inn & Suites by Marriott Sikeston. See all available top hotels, or vacation rentals in New Madrid.
If I need to cancel my hotel reservation in New Madrid, will I receive a refund?
Yes, most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in New Madrid.
Where can I learn more about changing or cancelling my trip to New Madrid?
For additional details about updating your trip to New Madrid or cancelling it, head over to our customer service page.
What's the best hotel to stay with easy access to New Madrid Historical Museum?
Travel Inn is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. You'll find it 6.8 mi (10.9 km) from New Madrid Historical Museum. Other good options around the area include Reelfoot Lake Inn and Lodge that sleeps 16! Ideal for Fishermen, Family reunions, Hunters and Tourist!.
What about the best place to stay near Hunter-Dawson State Historic Site?
One of the top choices for your stay is Travel Inn, located 7.2 mi (11.6 km) from Hunter-Dawson State Historic Site, and this hotel offers free breakfast and free parking. Reelfoot Lake Inn and Lodge that sleeps 16! Ideal for Fishermen, Family reunions, Hunters and Tourist! are other good choices within the area.
What's the best accommodation near Cairo Regional Airport (CIR)?
Quality Inn Cairo I-57 is one of the top choices for your stay and is a popular hotel, featuring free breakfast and free WiFi. It's located 2.1 mi (3.3 km) from Cairo Regional Airport.
What is staying in New Madrid like?
Visitors can enjoy all that New Madrid has to offer including the parks and museums. There are 58 hotels and other accommodations in the surrounding area. Find out more about New Madrid.
What are the top places to visit in New Madrid?
Cultural venues include New Madrid Historical Museum and Hunter-Dawson State Historic Site. A couple of additional sights to add to your agenda are Mississippi River and River Ridge Winery. Check out what more to see and do in Expedia's New Madrid guide.
What's the weather like in New Madrid?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 42°F. Average annual precipitation for New Madrid is 60 inches.

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