Top 10 Hotels in Santa Fe, FL from ₩76,165 - Competitive Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Pool

Condo

Hot tub

Family friendly

Cottage

Waterpark

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Fe hotels

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.

A hotel reception area with directional signs for elevators, floor 1, pool restrooms, and business center.

1. La Quinta by Wyndham Gainesville

Gainesville

Tiffany

₩127,989

₩143,988 total

includes taxes & fees

Sep 20 - Sep 21

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

2. Hampton Inn & Suites Alachua I-75

Alachua

Tara

₩141,914

₩159,653 total

includes taxes & fees

Sep 21 - Sep 22

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

A spacious lobby with a large painting, a fireplace, a piano, and multiple seating areas.

3. Best Western Gateway Grand

Gainesville

Ammarica

₩113,446

₩127,627 total

includes taxes & fees

Sep 21 - Sep 22

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.

A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

4. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Tobias

₩139,526

₩156,967 total

includes taxes & fees

Sep 21 - Sep 22

A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

A fire pit area surrounded by stone tiles, with a metal fence in the background.

A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.

A modern hotel lobby with a reception desk, seating area with chairs and ottomans, a large artwork, and a corridor leading to other rooms.

5. Comfort Suites Gainesville near University

Gainesville

Gladys

₩107,462

₩120,895 total

includes taxes & fees

Sep 21 - Sep 22

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

A hotel room with a large window offering a view of a cityscape, a blue armchair, and a small table with a lamp.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

6. Drury Inn & Suites Gainesville

Gainesville

Shirley

₩140,855

₩158,462 total

includes taxes & fees

Sep 20 - Sep 21

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

A spacious lobby with modern furniture, large windows, and a colorful abstract wall.

A modern bar area with a marble countertop, bar stools, and pendant lighting.

A modern hotel lobby with a round table featuring two drinks, a sofa, and a colorful wall art piece.

7. Hyatt Place Gainesville Downtown

Downtown Gainesville

maria

₩131,477

₩147,911 total

includes taxes & fees

Sep 21 - Sep 22

A spacious hotel lobby with a curved sofa, a patterned carpet, and a large window with sheer curtains.

A large banquet hall with round tables, chairs, and floral centerpieces.

A Hilton hotel with a brick facade, multiple windows, and a well-lit entrance.

A hotel lobby with a blue patterned carpet, black round tables with candles, beige sofas, and a curved seating area.

8. Hilton University of Florida Conference Center Gainesville

Gainesville

Nandini

₩163,917

₩184,406 total

includes taxes & fees

Sep 21 - Sep 22

A hotel room with a sofa, a desk, a chair, a bed, a TV, and a dining table with a glass and cookie.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

9. Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

Arleana

₩152,942

₩173,780 total

includes taxes & fees

Sep 17 - Sep 18

A multi-story hotel with a central entrance, palm trees, and a clear sky.

A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.

A modern living room with a green sofa, a round coffee table, and a fireplace.

A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.

10. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

Henry

₩118,597

₩133,422 total

includes taxes & fees

Sep 21 - Sep 22

A hotel room with two beds, a desk, a chair, and a television.

A bathroom with a white sink, mirror, and towel rack.

A parking lot with marked lanes and a grassy area on one side.

A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.

11. Royal Inn

Alachua

Alec

₩96,595

₩108,669 total

includes taxes & fees

Sep 21 - Sep 22

A hotel room with two beds, a ceiling fan, a TV, and a desk with a chair.

A hotel with a modern facade, a covered entrance, and a palm tree in front.

A modern dining area with tables and chairs, a kitchen counter, and a sign reading "höm cooking".

12. HOM Hotel Gainesville, SureStay Collection by Best Western

Gainesville

Armando Serradet

₩97,186

₩109,334 total

includes taxes & fees

Sep 21 - Sep 22

A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.

A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.

A hotel hallway with carpeted floors, doors on both sides, and overhead lighting.

A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

13. Hampton Inn Gainesville

Gainesville

Charles

₩122,193

₩137,467 total

includes taxes & fees

Sep 17 - Sep 18

A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.

A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.

An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.

A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.

14. Holiday Inn Express Starke by IHG

Starke

Judy

₩147,576

₩163,809 total

includes taxes & fees

Sep 20 - Sep 21

A modern bar area with a long counter, green bar stools, and a television displaying a golf game.

A modern kitchen with a central island, bar stools, pendant lighting, and a dining area with a sofa and chairs.

A modern living room with a fireplace, comfortable seating, and a large TV.

A modern hotel room with a large bed, a desk, a chair, and a TV mounted on the wall.

15. Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

Robert

₩159,650

₩179,607 total

includes taxes & fees

Sep 20 - Sep 21

A modern hotel lobby with a curved ceiling, a central seating area with a sofa and ottoman, a bar area, and a dining space with chairs and tables.

A spacious lobby with a modern design, featuring a large seating area with sofas and chairs, a patterned carpet, and large windows offering views of the outside.

A hotel reception area with a curved reception desk, a refrigerator stocked with beverages, and a wall with a blue abstract design.

A modern hotel lobby with a breakfast bar, seating area, and a large window.

16. SpringHill Suites by Marriott Gainesville

Gainesville

Robert

₩118,597

₩133,422 total

includes taxes & fees

Sep 20 - Sep 21

A Courtyard by Marriott hotel with a covered entrance, outdoor seating, and a well-lit facade.

A modern living room with a large flat-screen TV, built-in shelves, a glass coffee table, and a seating area with sofas and chairs.

A modern restaurant with multiple tables and chairs, a counter with a menu board, and a coffee machine.

A hotel room with a bed, desk, chair, TV, and a small kitchenette.

17. Courtyard by Marriott Gainesville FL

Gainesville

Jvotric

₩113,295

₩127,458 total

includes taxes & fees

Sep 20 - Sep 21

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.

A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

18. BlueGem Motel

High Springs

Wesley

₩125,116

₩140,756 total

includes taxes & fees

Sep 16 - Sep 17

An outdoor patio with wicker furniture, stone walls, and a barbecue grill.

TownePlace Suites Marriott with a modern exterior, multiple windows, and a covered entrance area.

A modern hotel room with a flat-screen TV, a dining area with a table and chairs, a kitchenette, and a wardrobe with hanging space.

A modern dining area with a wooden table, blue upholstered chairs, and pendant lighting.

19. TownePlace Suites by Marriott Gainesville Northwest

Gainesville

Tanya

₩140,492

₩158,053 total

includes taxes & fees

Sep 20 - Sep 21

A clean, modern cafe with a marble floor, a counter with coffee machines, and a clock on the wall.

A hotel room with two beds, a wooden headboard, a flat-screen TV, a desk with a chair, and a bathroom visible through an open door.

A corner of a store with shelves stocked with snacks, beverages, and a refrigerated display case.

A workspace with two chairs, a desk, a computer monitor, and a wall-mounted sign reading 'BUSINESS CENTER'.

20. Clarion Pointe Alachua - Gainesville Area

Alachua

YESSICA

₩61,740

₩76,165 total

includes taxes & fees

Sep 27 - Sep 28

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

Hotel Eleo at the University of Florida

10/10 Excellent

"There's a good variety of food everything was good. The room was kept clean with new towels and sheets while I was away. A late checkout option would be helpful."

Sleep Inn & Suites University/Shands

10/10 Excellent

"The facilities were clean and the staff was excellent. Perfect place for gator game day with the complementary shuttle from the hotel to the stadium and back."

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent

"Quick and easy to the interstate and close to good dinning options."

Red Roof Inn PLUS+ Gainesville

8/10 Good

"It’s the red roof ya know. This was still a nice stay mainly because of the staff being so friendly, we all enjoyed the pool my daughter especially and they allow 1 pet to stay for free so we were able to bring along our dog! We did have to request a new room our first night there - the one they originally gave us was extremely broke down and honestly shouldn’t be allowed to be rented out until the several Required repairs are complete, BUT they didn’t give us any hassle. Just went back down to the front desk requested something else and they gave a cleaner/better room on the same floor which made moving easy peasy. I’ve stayed here before in the past and it’s always an ok experience as far as quality goes, but you can’t beat the rate + location + great staff & the pool was clean and cool which makes up for quality in my opinion."

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Overall, room was nice and clean. Bed was comfortable. AC cooled off super quick and fast. We had it nice and freezing like we love. We had space for our family of 5 to sleep in comfortable. The only complaint was that the sofa bed mattress was uncomfortable. Other than that, it was a great stay. I would stay again. Staff was friendly and helpful."

Best Western Gateway Grand

10/10 Excellent

"I highly recommend stay at this hotel. Very clean and the staff was really nice. Only issue is our toilet was stopped up when we got there."

HOM Hotel Gainesville, SureStay Collection by Best Western

8/10 Good

"First time staying here. Clean and had wonderful hot water in the rooms! Nice staff. Convenient to restaurants and UF."

Comfort Inn Gainesville - University Area

10/10 Excellent

"Great staff. Game day decorations were fun."

Holiday Inn Gainesville - University Center by IHG

10/10 Excellent

"Very nice and convenient to the campus."

More cheap stays in Santa Fe

Days Inn by Wyndham Gainesville Hospital/University Area

2649 Sw 13th St Gainesville FL

₩82,844

₩93,199 total

Sep 16 - Sep 17

includes taxes & fees

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

₩96,931

₩109,048 total

Sep 17 - Sep 18

includes taxes & fees

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

₩97,186

₩109,334 total

Sep 21 - Sep 22

includes taxes & fees

8.6/10 Excellent! (2,130 reviews)

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL

₩98,391

₩118,263 total

Oct 15 - Oct 16

includes taxes & fees

8.2/10 Very Good! (1,093 reviews)

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

₩107,462

₩120,895 total

Sep 21 - Sep 22

includes taxes & fees

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

₩101,492

₩121,725 total

Oct 5 - Oct 6

includes taxes & fees

8.8/10 Excellent! (1,308 reviews)

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and DoubleTree by Hilton Gainesville. See all available top hotels, or vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

What is staying in Santa Fe like?

Travelers to Santa Fe will find plenty to explore and enjoy. There are 807 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.

What are the top places to visit in Santa Fe?

Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.

What's the seasonal weather like in Santa Fe?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

Explore a world of travel with Expedia

More ways to book

Book Hotels in Santa Fe on Expedia.com

Find hotels in Santa Fe, FL from ₩76,165

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe hotels

1. La Quinta by Wyndham Gainesville

2. Hampton Inn & Suites Alachua I-75

3. Best Western Gateway Grand

4. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

5. Comfort Suites Gainesville near University

6. Drury Inn & Suites Gainesville

7. Hyatt Place Gainesville Downtown

8. Hilton University of Florida Conference Center Gainesville

9. Hotel Indigo Gainesville-Celebration Pointe by IHG

10. Country Inn & Suites by Radisson, Gainesville, FL

11. Royal Inn

12. HOM Hotel Gainesville, SureStay Collection by Best Western

13. Hampton Inn Gainesville

14. Holiday Inn Express Starke by IHG

15. Fairfield Inn & Suites by Marriott Gainesville I-75

16. SpringHill Suites by Marriott Gainesville

17. Courtyard by Marriott Gainesville FL

18. BlueGem Motel

19. TownePlace Suites by Marriott Gainesville Northwest

20. Clarion Pointe Alachua - Gainesville Area

Top Santa Fe Hotel Reviews

Hotel Eleo at the University of Florida

Sleep Inn & Suites University/Shands

Country Inn & Suites by Radisson, Gainesville, FL

Red Roof Inn PLUS+ Gainesville

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Best Western Gateway Grand

HOM Hotel Gainesville, SureStay Collection by Best Western

Comfort Inn Gainesville - University Area

Holiday Inn Gainesville - University Center by IHG

More cheap stays in Santa Fe

Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Comfort Inn Gainesville - University Area

Comfort Suites Gainesville near University

Sleep Inn & Suites University/Shands

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app