The Best Hotels Closest to Santo Spirito Hospital in Rome for 2026

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Our top choices for Santo Spirito Hospital hotels

A historic building with a cobblestone street, a well-lit entrance, and a car parked nearby.

A room with a leather chair, a small table with a bottle and glasses, a vase with flowers, and a large window with curtains.

A balcony with a table set for breakfast, including plates of food, drinks, and a basket of bread.

A well-lit, elegant room with a bar area featuring a wine and glass display, comfortable seating, and a large painting on the wall.

1. Hotel De' Ricci - Small Luxury Hotels of The World

Regola, 0.7 km from Santo Spirito Hospital

William

₩777,479

₩877,745 total

includes taxes & fees

Nov 2 - Nov 3

A building with a large wooden door, a shop with a green sign, and a signboard with contact information.

A modern kitchen with a built-in oven, a kettle, and a toaster. There is a window with a view of buildings outside.

A hotel room with a bed, a seating area, a wardrobe, and a view of buildings through a window.

A room with a bed, a sink, and curtains.

2. GV Suite Collection

Prati, 0.8 km from Santo Spirito Hospital

"Great location in a quieter area with all attractions easy to get to. Shelf check in was easy and the lift (albeit old) was super helpful as we had lots of luggage. Room was well maintained and clean, the bath was a delight after a long days stroll. Communal coffee area was a lovely touch and we used several times during our stay. Safe, secure and plenty of space! Highly recommend and can’t wait to return."

Melissa

₩395,499

₩456,066 total

includes taxes & fees

Nov 7 - Nov 8

A building with a large wooden door, a small window with a metal grille, and a potted plant in front.

A historical fortification with brick walls and a grassy mound, surrounded by tall trees and a clear sky.

A neatly made bed with a headboard, a bedside table with a lamp, and a view of the outdoors through a window with curtains.

A modern hotel room with a grey sofa, teal armchair, and a large peacock painting on the wall.

3. Porta Castello Suites

0.5 km from Santo Spirito Hospital

Emily

₩141,719

₩176,908 total

includes taxes & fees

Nov 9 - Nov 10

An outdoor seating area with a table and chairs, a potted plant, and a building entrance.

A bedroom with a large bed, a wooden ceiling, a brick wall, and a small table with a chair.

A bar area with a counter, shelves with bottles, and stools.

A reception area with a receptionist, a yellow chair, a lamp, and a vase with sticks.

4. Passpartout Boutique Palace

0.4 km from Santo Spirito Hospital

Mauricio

₩320,031

₩373,052 total

includes taxes & fees

Nov 8 - Nov 9

A grand staircase leading to a street view, with ornate wall sconces and a clear view of parked cars and trees outside.

A modern room with a wooden desk, a chair, a mounted TV, a radiator, a window, a sink, and a trash bin.

A hotel reception area with a herringbone floor, a bar, and a reception desk.

A historic building with a pink facade, ornate architectural details, and a gated entrance.

5. Eccelso Hotel

Prati, 0.8 km from Santo Spirito Hospital

Michelle

₩191,743

₩228,931 total

includes taxes & fees

Nov 10 - Nov 11

The entrance of Hotel S. Anna with a covered entrance, a staircase leading inside, and a sign indicating the hotel's name.

A hotel room with a large bed, a desk, and a chair. There is a television and a window with curtains.

A grand lobby with a chandelier, a round wooden table, a red carpeted staircase, and a large painting.

A reception area with a wooden reception desk, framed artwork, a stone sculpture, and a staircase leading to an upper level.

6. Hotel Sant' Anna

0.5 km from Santo Spirito Hospital

Tammie

₩306,877

₩355,579 total

includes taxes & fees

Nov 8 - Nov 9

A view through a window of a courtyard with classical architecture, including a bell tower and a dome.

A bathroom with a bathtub, wooden ceiling beams, a flat-screen TV, and a window with curtains.

A room with a dark wooden cabinet, a glass display case with items, and a window with curtains.

A terrace with a table and chairs, a view of a church with a dome and bell tower, and a tiled roof.

7. Palazzo Gambirasi Luxury Suite Roma

Ponte, 0.7 km from Santo Spirito Hospital

Michael

₩253,418

₩299,779 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor patio with wooden flooring, lounge chairs, and umbrellas.

A building with a balcony and arched windows, surrounded by lush green trees.

A modern bathroom with a freestanding bathtub, a marble accent wall, and a large window with curtains.

A modern interior with a glass partition, a white sofa, and a potted plant.

8. Horti 14 Borgo Trastevere Hotel

0.7 km from Santo Spirito Hospital

Erin

₩262,915

₩311,724 total

includes taxes & fees

Nov 10 - Nov 11

A building facade with multiple windows, a balcony, and a sign for 'Carrefour express'.

A compact kitchen with a wooden countertop, grey cabinets, and a built-in shelf. There is a dining table with chairs, a vase with flowers, and a window with curtains.

A round table with a book and a bottle on it, surrounded by red chairs.

9. Passepartout

Parione, 0.6 km from Santo Spirito Hospital

Richard

₩277,804

₩320,596 total

includes taxes & fees

Nov 10 - Nov 11

A modern hotel room with a large bed, a desk with a chair, a glass door leading to a balcony, and a sculpture on the wall.

A modern hotel room with a large bed, a sitting area with a glass table, and a balcony with a view.

A modern bathroom with a large bathtub, a mirror, and a mosaic wall.

A breakfast setup with bread, pastries, and cutlery on a tray.

10. Vatican Style

0.5 km from Santo Spirito Hospital

Leida A.

₩182,488

₩215,749 total

includes taxes & fees

Nov 10 - Nov 11

A bedroom with two beds, a large mirror, a potted plant, and a painting on the wall.

A hallway with a white wall, a green moss wall art, and a shelf with a white vase and a black vase.

A compact, white-framed walk-in closet with a built-in black refrigerator and a shelf above it.

A dining area with a wooden table and chairs, a clock on the wall, and a decorative wall piece.

11. Capricci Romani

0.4 km from Santo Spirito Hospital

Ling

₩132,817

₩161,111 total

includes taxes & fees

Nov 9 - Nov 10

A building facade with two arched doorways, one labeled "NOW" and the other with a number "3".

A modern interior with a brick wall, a large mirror, a chair with a colorful cushion, and potted plants.

A modern hotel room with a bed, a desk with a laptop, a chair, a TV mounted on the wall, and a window with curtains.

A reception desk with a modern design, a brick wall, and a framed artwork above it.

12. Now Apartments

Ponte, 0.6 km from Santo Spirito Hospital

Hyejeong

₩307,061

₩355,781 total

includes taxes & fees

Nov 5 - Nov 6

A rooftop terrace with a hot tub, outdoor seating, and a view of a large building with a dome.

An outdoor bar area with a stone wall backdrop, a bar counter, and seating arrangements.

A modern hotel room with a wooden desk, a flat-screen TV, a coffee maker, and a vase with green plants.

A rooftop terrace with a hot tub, lounge chairs, and a table with fruit and drinks. In the background, there is a large building with a dome.

13. Le Boutique Hotel

0.8 km from Santo Spirito Hospital

Amy

₩292,245

₩343,987 total

includes taxes & fees

Nov 8 - Nov 9

A narrow street with a large wooden door and a motorcycle parked nearby.

A modern room with a desk, chairs, a TV, a shower, and a bed.

A narrow hallway with white walls and a wooden floor. There is a door at the end with a sign above it.

A narrow urban street with multi-story buildings, a balcony with a potted plant, and a clear blue sky.

14. B&B At Your Place

0.4 km from Santo Spirito Hospital

Liliana

₩190,685

₩227,767 total

includes taxes & fees

Nov 1 - Nov 2

A cobblestone street with outdoor seating, a chalkboard sign with reception hours, and potted plants.

A multi-story building with a classic architectural style, featuring arched windows and shutters.

A bedroom with a large bed, a wooden headboard, a chandelier, and a bathroom door.

A cozy living room with a large plant, a floor lamp, a red armchair, and a bookshelf.

15. BRAMA by HiSuiteRome

Ponte, 0.6 km from Santo Spirito Hospital

Pawel

₩429,885

₩493,891 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bed, a bedside table, a nightstand, a mirror, and a painting on the wall.

A kitchen with white cabinets, a gas stove, a kettle, and a toaster.

A hallway with wooden flooring, a fire extinguisher, and a painting on the wall.

A room with a sliding glass door leading to a balcony with a metal railing.

16. Fornaci House

0.5 km from Santo Spirito Hospital

Walter

₩268,617

₩445,597 total

includes taxes & fees

Nov 5 - Nov 6

A reception area with a wooden wall displaying "PIE DRAMA" text, a reception desk, two bar stools, a potted plant, and a globe ornament.

A modern hotel lobby with a bar area, seating, and a large abstract painting on the wall.

A modern hotel room with a round dining table, grey chairs, a coffee machine, and a bookshelf.

A modern hotel room with a large bed, a flat-screen TV mounted on the wall, a small round table, a sofa, and a mirror.

17. Boutique Hotel Piedra Rome City Centre

Prati, 0.5 km from Santo Spirito Hospital

Daisy Ellen Margaret

₩172,744

₩208,032 total

includes taxes & fees

Nov 8 - Nov 9

A table with a bottle of white wine, two glasses, a vase with white flowers, and a plate with various food items.

A spacious lobby with a sofa, chairs, a coffee table, and a vase of flowers.

A lobby with a marble floor, a bar area with stools, and a large window with a plant in the center.

A StarHotels building with a large illuminated sign, parked motorcycles, and a historic dome in the background.

18. Starhotels Michelangelo

0.7 km from Santo Spirito Hospital

Adriana

₩287,380

₩338,632 total

includes taxes & fees

Nov 9 - Nov 10

A view from a window overlooking a busy street with buildings and cars.

A corner building with classical architecture, including a balcony with balustrades, multiple windows with shutters, and a sign indicating a street name.

A coffee station with multiple espresso machines, a coffee cup, sugar packets, and a vase with flowers.

A dark brown door with a brass nameplate reading "LETTEPE" and a brass door knocker.

19. Maison Ottavia

Ponte, 0.4 km from Santo Spirito Hospital

Javier

₩232,261

₩270,499 total

includes taxes & fees

Nov 10 - Nov 11

A balcony with a view of historic buildings and a table with a vase of flowers.

A corner building with a balcony, multiple windows with shutters, and a classical architectural style.

A modern room with a desk, two chairs, a laptop, a lamp, and a mirror.

A hotel room with a bed, a sofa, a dining table with chairs, a chandelier, and a view of the outside.

20. Boutique Hotel Atelier '800

Ponte, 0.4 km from Santo Spirito Hospital

James

₩248,720

₩288,604 total

includes taxes & fees

Nov 9 - Nov 10

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Hotels recommended for families near Santo Spirito Hospital

A historic building with a large dome, a cobblestone street, and a person riding a bicycle.

A hotel with outdoor seating, multiple floors, and a cobblestone street.

A cobblestone street lined with yellow buildings, outdoor seating, and a hotel entrance.

A breakfast table with pastries, fruits, and beverages in a hotel room.

Hotel della Conciliazione

Rome City Centre

₩259,774

₩308,269 total

includes taxes & fees

Nov 1 - Nov 2

Horti 14 Borgo Trastevere Hotel

Rome City Centre

₩262,915

₩311,724 total

includes taxes & fees

Nov 10 - Nov 11

A historic bridge with arches leading to a large domed building, likely a significant landmark.

A lobby with a glass coffee table displaying magazines, a staircase with a metal railing, and a bar area with chairs and a counter.

A hotel facade with a symmetrical design, featuring a central entrance with a double door and a small balcony.

A marble staircase with a wrought iron railing and a floral chandelier.

Hotel Dei Mellini

Rome City Centre

₩417,270

₩481,521 total

includes taxes & fees

Nov 7 - Nov 8

A balcony table with breakfast items, overlooking a cityscape with a prominent dome building.

A buffet setup with various food items and coffee machines.

A multi-story hotel with a rooftop garden, illuminated windows, and a classic architectural style.

A four-poster bed with white linens and gray pillows, a white armchair, a small bedside table with a lamp, and a window with curtains.

Hotel Isa

Rome City Centre

₩294,779

₩346,775 total

includes taxes & fees

Nov 2 - Nov 3

A rooftop terrace with a dining area, a view of historic buildings, and a sign reading "Coronari Palace".

A modern living room with a grey sofa, a small table, and a wardrobe.

A modern dining area with round tables and yellow cushioned chairs, surrounded by large green plants.

A modern hotel room with a bed, a chair, a small table, a coat rack, a TV, a bathroom with a mirror, and a window with curtains.

Coronari Palace by Hannah Hotels Collection

Rome City Centre

₩272,541

₩317,809 total

includes taxes & fees

Nov 1 - Nov 2

A large, dark wooden double door with the inscription "A.D. MC MXV" above it.

A hotel room with a large bed, a desk, a chair, a small table, and a sofa.

A hallway with two green velvet armchairs and a gold table, white walls, and a wooden floor.

A room with a wooden door, a white wall, a small table with a plant, and a mirror on the wall.

Les Chambres d' Or

Rome City Centre

₩163,688

₩192,066 total

includes taxes & fees

Nov 4 - Nov 5

A historic building with a courtyard, arched windows, and a prominent entrance.

A grand staircase with ornate gold detailing and classical columns, leading to a richly decorated room.

An outdoor patio with round tables and chairs, a large umbrella, and potted plants.

A modern interior with arched mirrors, a reception desk, and pendant lighting.

Donna Camilla Savelli – VRetreats

Rome City Centre

₩323,218

₩378,116 total

includes taxes & fees

Nov 9 - Nov 10

A balcony with a table set with two glasses of red drink, a bowl of nuts, and a vase of flowers.

A modern living area with a staircase, a bottle of champagne, glasses, and a tray with snacks.

A bedroom with a large bed, a brick wall, a window with a view of buildings, and a vase with flowers.

A hotel entrance with a reception desk, a potted plant, and a stone fountain.

Argentina Residenza Style Hotel

Rome City Centre

₩350,022

₩407,542 total

includes taxes & fees

Nov 10 - Nov 11

Top Santo Spirito Hospital Hotel Reviews

Trastevere Roma | UNA Esperienze | Preferred Hotels and Resorts

10/10 Excellent

"The hotel was clean and very pretty, staff was kind and helpful. Always quick response with pre planning our trip, including setting up airport pickup and transfer to cruise port. Breakfast was delicious!"

Hotel Quirinale

10/10 Excellent

"Very clean and beautiful hotel"

Hotel Nazionale

10/10 Excellent

"An excellent trip. They were very clean and very nice with everything they did. Would come back here again. Breakfast service was great"

Hotel Delle Nazioni

8/10 Good

"Room was clean, staff was a bit unclear on parking when communicating via messages. Was told parking is ready and phone call was made but when we arrived at parking lot it was full but thankfully the lot attendant let us in. It can be loud at night but good location overall"

Hotel Raphaël – Relais & Châteaux

10/10 Excellent

"Second time we stayed here because we love it so much and the staff is unbelievable! Everyone is so friendly and they recommend great restaurants. My husband enjoyed talking with the incredible staff because they were so helpful. The breakfast was absolutely gorgeous!"

Vatican Style

10/10 Excellent

"Rooms were clean and well appointed. Beds were comfortable which isn’t always the norm in Europe. Very convenient location to the Vatican."

Villa Agrippina Gran Meliá - The Leading Hotels of the World

10/10 Excellent

"Lujo y servicio de las más alta calidad y estándar mundial. Excelentes habitaciones, comida fabulosa."

Argentina Residenza Style Hotel

10/10 Excellent

"Amazing experience. Zero complaints. Wonderful."

Hotel della Conciliazione

10/10 Excellent

"Breakfast was very good. We didnt have any hand soap or body soap in the shower. Both containers were empty and not refilled on the next day clean. The floor in the room wasn't very clean. Very nice patio outside our room. Its very close to the Vatican. Great location!"

Frequently asked questions

What's the area like around Santo Spirito Hospital?

Santo Spirito Hospital is located in a historic area of Rome known for its stunning cathedral and notable monuments. If you're looking for a convenient place to stay, check out the 1955 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Santo Spirito Hospital?

Adjacent to Santo Spirito Hospital, Villa Agrippina Gran Meliá - The Leading Hotels of the World is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good options close by include Hotel Abruzzi and Vatican Style.

How many hotels will I be able to find close to Santo Spirito Hospital?

Expedia has 1955 hotels and other accommodations within a mile from Santo Spirito Hospital.

If I need to cancel the hotel reservation for my stay near Santo Spirito Hospital, will I receive a refund?

Yes! The majority of hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to get top deals close to Santo Spirito Hospital.

Where can I learn more about changing or cancelling my trip in the area near Santo Spirito Hospital?

For more information about changing or cancelling your stay near Santo Spirito Hospital, head over to our customer service page.

What can I see and do near Santo Spirito Hospital?

You might want to spend some time browsing the exhibits at Castel Sant'Angelo, Cloister of Bramante, or Palazzo Spada. Piazza Navona, Pantheon, and Trevi Fountain are well-known local landmarks worth a visit. You can check out the local talent at Auditorium Conciliazione, Paul VI Audience Hall, and Sistina Theater.

How can I get to Santo Spirito Hospital?

With so many choices for transportation, seeing all of the area near Santo Spirito Hospital is simple. You can access metro transit at Venezia Tram Stop, Arenula-Cairoli Tram Station, and Barberini Station. If you'd like to explore more of the area, hop aboard a train from Rome Piazzale Flaminio Station, Rome Termini Station, or Rome (XRJ-Termini Rail Station).

Find hotels near Santo Spirito Hospital, Rome from ₩161,111

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Be picky

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Our top choices for Santo Spirito Hospital hotels

1. Hotel De' Ricci - Small Luxury Hotels of The World

2. GV Suite Collection

3. Porta Castello Suites

4. Passpartout Boutique Palace

5. Eccelso Hotel

6. Hotel Sant' Anna

7. Palazzo Gambirasi Luxury Suite Roma

8. Horti 14 Borgo Trastevere Hotel

9. Passepartout

10. Vatican Style

11. Capricci Romani

12. Now Apartments

13. Le Boutique Hotel

14. B&B At Your Place

15. BRAMA by HiSuiteRome

16. Fornaci House

17. Boutique Hotel Piedra Rome City Centre

18. Starhotels Michelangelo

19. Maison Ottavia

20. Boutique Hotel Atelier '800

Hotels recommended for families near Santo Spirito Hospital

Hotel della Conciliazione

Horti 14 Borgo Trastevere Hotel

Hotel Dei Mellini

Hotel Isa

Coronari Palace by Hannah Hotels Collection

Les Chambres d' Or

Donna Camilla Savelli – VRetreats

Argentina Residenza Style Hotel

Top Santo Spirito Hospital Hotel Reviews

Trastevere Roma | UNA Esperienze | Preferred Hotels and Resorts

Hotel Quirinale

Hotel Nazionale

Hotel Delle Nazioni

Hotel Raphaël – Relais & Châteaux

Vatican Style

Villa Agrippina Gran Meliá - The Leading Hotels of the World

Argentina Residenza Style Hotel

Hotel della Conciliazione

Frequently asked questions