Find Resorts & Hotels with Spas in Southwest Illinois, IL

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southwest Illinois Resorts & Hotels with Spas

Top Southwest Illinois Resorts & Hotels with Spas

Our top choices for Southwest Illinois hotels with a spa

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"The hotel was very nice and the staff were super helpful. I would stay here again!"
The price is ₩144,127
₩162,595 total
includes taxes & fees
Sep 1 - Sep 2
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Walker's Bluff Casino Resort
Indoor pool, seasonal outdoor pool

Walker's Bluff Casino Resort

4.5 star property
9.4 out of 10, Exceptional, (364)
"I would love to stay here again, shoutout to their beds!! "
The price is ₩239,209
₩265,474 total
includes taxes & fees
Sep 2 - Sep 3
Walker's Bluff Casino Resort
Ameristar Casino Resort and Spa
6 restaurants, breakfast served

Ameristar Casino Resort and Spa

4.5 star property
8.4 out of 10, Very Good, (1001)
"Loved my stay here will be back "
The price is ₩229,833
₩291,821 total
includes taxes & fees
Sep 8 - Sep 9
Ameristar Casino Resort and Spa
21C Museum Hotel St Louis
Exterior

21C Museum Hotel St Louis

4.5 star property
9.0 out of 10, Wonderful, (1316)
"Amazing hotel!"
The price is ₩212,902
₩255,940 total
includes taxes & fees
Aug 31 - Sep 1
21C Museum Hotel St Louis
Four Seasons Hotel St Louis
Rooftop bar

Four Seasons Hotel St Louis

5.0 star property
9.4 out of 10, Exceptional, (1000)
"We’ve stayed at this hotel several times and keep coming back. Great hotel staff and property. "
The price is ₩594,698
₩695,375 total
includes taxes & fees
Aug 24 - Aug 25
Four Seasons Hotel St Louis
The Ritz-Carlton, St. Louis
Meeting facility

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (544)
"Great place"
The price is ₩726,232
₩845,983 total
includes taxes & fees
Sep 21 - Sep 22
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites Marion

Drury Inn & Suites Marion

10/10 Excellent
"10 out of 10. If you have been to a Drury Inn, you know. If you haven't, go to one now and you'll understand!"
Chris 1-night trip
Posted 3 days ago
Drury Inn & Suites Marion