Clayton, MO

St. Louis

The illuminated Gateway Arch at night with a city skyline in the background.
A city skyline with a prominent arch bridge reflecting on the water.
A city skyline with a prominent arch bridge at sunset.
A gazebo with a green roof, surrounded by a pond, with red and green foliage in the background.
A historic building with a courtyard, surrounded by lush green grass and trees.

Stay near popular Clayton attractions

Washington University in St. Louis

8.8/10 (1,777 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
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Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ₩143,123 per night from Aug 9 to Aug 10
₩143,123
₩167,079 total
Aug 9 - Aug 10
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (3,304 reviews)
"Booked 3 rooms 7 weeks in advance. Requested close to elevator and rooms close together. One room C was issued, was told others not ready. Many people were checking in behind me. Ended up with all room separated; 2 furthest from elevator, back in corner on separate floors. I feel that was done because ..."

Reviewed on Jul 28, 2026

Clayton Plaza Hotel & Extended Stay
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
The price is ₩191,137 per night from Aug 2 to Aug 3
₩191,137
₩225,042 total
Aug 2 - Aug 3
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the helpful staff ...
8.8/10 Excellent! (1,007 reviews)
"Very convenient Clayton location. We were in town to see The Muny."

Reviewed on Jul 28, 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ₩223,052 per night from Aug 8 to Aug 9
₩223,052
₩262,617 total
Aug 8 - Aug 9
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
The price is ₩193,952 per night from Aug 27 to Aug 28
₩193,952
₩226,416 total
Aug 27 - Aug 28
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
9.2/10 Wonderful! (351 reviews)
"The room is very clean and modern style. Convenient location. Great service. Enjoyed the experience. The only issue was that the ticket machine at the self-parking garage did not have a parking fee receipt."

Reviewed on Jul 26, 2026

AC Hotel St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ₩222,979 per night from Aug 11 to Aug 12
₩222,979
₩262,958 total
Aug 11 - Aug 12
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (4,155 reviews)
"staff"

Reviewed on Jul 28, 2026

Hyatt Regency St. Louis at The Arch
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ₩190,565 per night from Aug 2 to Aug 3
₩190,565
₩243,741 total
Aug 2 - Aug 3
includes taxes & fees
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,217 reviews)
"Love staying at this hotel!"

Reviewed on Jul 27, 2026

Hollywood Casino & Hotel St. Louis
See all 2,006 properties in Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

An ornate hall with arched ceilings and intricate patterns.
Photo by Terry Eaves
Open Photo by Terry Eaves

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

A modern building with a brick facade, parked cars, and a flower bed with tulips.

Central West End

The ample dining options and lush forests are just a few popular features of the neighborhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A historic brick building with arched doorways and a sign that reads "Hot Goods Pen House."

St. Charles Historic District

St. Charles Historic District is known for its abundant dining options, and you can plan a trip to Historic Main Street and Missouri River while you're in town.

Clayton, MO