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Our top choices for East Seneca hotels

Property entrance
Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
2.5 star property
10.6 km from East Seneca
8.2 out of 10, Very Good, (1004)
"The room was clean, breakfast options were ok, staff is excellent, friendly, helpful. It was a great stay."
United States
CESAR
The price is ₩136,958
₩155,790 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
Lobby
Comfort Inn & Suites Buffalo Airport

Comfort Inn & Suites Buffalo Airport

Comfort Inn & Suites Buffalo Airport
3.0 star property
10.9 km from East Seneca
8.2 out of 10, Very Good, (1275)
"Very nice stay"
United States
James
The price is ₩142,032
₩161,562 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Comfort Inn & Suites Buffalo Airport
Exterior
The Mansion On Delaware Ave

The Mansion On Delaware Ave

The Mansion On Delaware Ave
4.0 star property
Allentown, 14.9 km from East Seneca
9.4 out of 10, Exceptional, (1002)
"Fantastic place!"
Canada
Geneviève
The Mansion On Delaware Ave
Free daily on-the-go breakfast
Hampton Inn Buffalo-Hamburg

Hampton Inn Buffalo-Hamburg

Hampton Inn Buffalo-Hamburg
2.5 star property
15.2 km from East Seneca
9.0 out of 10, Wonderful, (1005)
"Friendly staff, clean rooms, pleasant and effective room design"
United States
Margaret
The price is ₩141,859
₩161,364 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Hampton Inn Buffalo-Hamburg
Free daily continental breakfast
Quality Inn Near Walden Galleria Mall

Quality Inn Near Walden Galleria Mall

Quality Inn Near Walden Galleria Mall
2.5 star property
8.4 km from East Seneca
8.0 out of 10, Very Good, (1001)
"Friendly staff, easy parking"
United States
Brittany
The price is ₩121,301
₩137,980 total
includes taxes & fees
Dec 30 - Dec 31
Quality Inn Near Walden Galleria Mall
Exterior
Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown
2.5 star property
Buffalo Theater District, 14.8 km from East Seneca
8.8 out of 10, Excellent, (1002)
"Great location "
United States
Oscar
The price is ₩192,692
₩224,967 total
includes taxes & fees
Jan 21 - Jan 22, 2026
Hampton Inn & Suites Buffalo Downtown
Exterior detail
Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown
3.0 star property
Buffalo Theater District, 14.3 km from East Seneca
8.6 out of 10, Excellent, (1002)
"Everything was amazing even the front desk very helpful and very knowledgeable about the area. Thanks for the hospitality "
United States
Omar
The price is ₩137,650
₩160,706 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Hilton Garden Inn Buffalo Downtown
Lobby lounge
Red Roof Inn Buffalo - Niagara Airport

Red Roof Inn Buffalo - Niagara Airport

Red Roof Inn Buffalo - Niagara Airport
2.0 star property
12.8 km from East Seneca
7.2 out of 10, Good, (1000)
"Room was very clean, staff very courteous "
United States
sonia
The price is ₩80,431
₩91,490 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Red Roof Inn Buffalo - Niagara Airport
Staircase
The Edward Hotel

The Edward Hotel

The Edward Hotel
3.0 star property
Elmwood Village, 15.8 km from East Seneca
9.6 out of 10, Exceptional, (219)
"Great location in Elmwood Village area. Clean room with gas fireplace. Self check- in was easy with staff provided instructions. Many food options within walking distance. "
United States
Jon
The Edward Hotel
Indoor pool
Sleep Inn Amherst - Buffalo North near University

Sleep Inn Amherst - Buffalo North near University

Sleep Inn Amherst - Buffalo North near University
2.5 star property
20.9 km from East Seneca
8.8 out of 10, Excellent, (1125)
"Nicely decorated for the holidays. Very friendly staff, great breakfast and clean comfy room."
United States
Karen
The price is ₩129,648
₩147,475 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Sleep Inn Amherst - Buffalo North near University
Exterior
Holiday Inn Express Amherst - Lockport by IHG

Holiday Inn Express Amherst - Lockport by IHG

Holiday Inn Express Amherst - Lockport by IHG
2.5 star property
28.7 km from East Seneca
9.2 out of 10, Wonderful, (739)
"Room was super clean. Front desk was super friendly and helpful. Breakfast buffet was great. "
Canada
Terra
The price is ₩148,491
₩167,795 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn Express Amherst - Lockport by IHG
Lobby
Extended Stay America Suites - Buffalo - Airport

Extended Stay America Suites - Buffalo - Airport

Extended Stay America Suites - Buffalo - Airport
2.5 star property
10.5 km from East Seneca
7.0 out of 10, Good, (1017)
"Would definitely stay again!"
United States
Yolanda
The price is ₩119,140
₩135,521 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Extended Stay America Suites - Buffalo - Airport
Courtyard view
Buffalo Airport Hotel

Buffalo Airport Hotel

Buffalo Airport Hotel
3.0 star property
11.2 km from East Seneca
8.0 out of 10, Very Good, (2800)
"Perfect for staying overnight !! "
United States
Lorena
The price is ₩126,953
₩144,408 total
includes taxes & fees
Dec 29 - Dec 30
Buffalo Airport Hotel
BBQ/picnic area
Tru by Hilton Williamsville Buffalo Airport

Tru by Hilton Williamsville Buffalo Airport

Tru by Hilton Williamsville Buffalo Airport
2.5 star property
13 km from East Seneca
8.8 out of 10, Excellent, (1004)
"Staff was very friendly. Loved the breakfast options."
United States
Fatima
The price is ₩140,677
₩160,020 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Tru by Hilton Williamsville Buffalo Airport
Lobby
La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst
3.0 star property
20.8 km from East Seneca
8.6 out of 10, Excellent, (1973)
"Nice hotel, beautiful clean room, very nice staff!!"
United States
William
The price is ₩116,414
₩132,422 total
includes taxes & fees
Jan 6 - Jan 7, 2026
La Quinta Inn & Suites by Wyndham Buffalo Amherst
Exterior
Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY
2.5 star property
18.7 km from East Seneca
9.4 out of 10, Exceptional, (1996)
"Great room, staff, breakfast, and pool- would definitely stay here again!"
United States
Madison
The price is ₩152,499
₩173,468 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hampton Inn Buffalo - Amherst, NY
Exterior
DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst
4.0 star property
18.5 km from East Seneca
7.8 out of 10, Good, (1001)
"Everything look great we will come back again😀"
United States
Cheekeong
The price is ₩123,421
₩140,392 total
includes taxes & fees
Jan 6 - Jan 7, 2026
DoubleTree by Hilton Hotel Buffalo - Amherst
Terrace/patio
Roycroft Inn

Roycroft Inn

Roycroft Inn
3.5 star property
10.8 km from East Seneca
9.6 out of 10, Exceptional, (845)
"Always a great stay for a Bills weekend. Love the bar. "
United States
Christine
Roycroft Inn
Reception hall
M Hotel Buffalo

M Hotel Buffalo

M Hotel Buffalo
3.5 star property
9.2 km from East Seneca
7.4 out of 10, Good, (2551)
"This is a very professional run hotel. One awesome aspect is the 24 hour security presence.all Staff are very polite."
United States
Antoine
The price is ₩128,452
₩146,112 total
includes taxes & fees
Dec 29 - Dec 30
M Hotel Buffalo
Lobby
Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham
3.5 star property
Buffalo Theater District, 14.3 km from East Seneca
8.6 out of 10, Excellent, (1003)
"I love the history in the hotel "
United States
Dylan
The price is ₩155,627
₩181,695 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Hotel at the Lafayette Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in East Seneca

Find the best East Seneca areas and neighborhoods for the activities you enjoy most.
Buffalo showing a city, a monument and a skyscraper

Downtown Buffalo

Experience the city's rich culture with visits to the oldest urban parks system in the US, Albright–Knox Art Gallery, and Shea's Performing Arts Center. Enjoy annual festivals and explore nearby universities.

Buffalo Theater District

Theaters, live music, and restaurants highlight some notable features of Buffalo Theater District. Make a stop by Shea's Performing Arts Center or Chippewa District while you're visiting, and jump aboard the metro at Fountain Plaza Station or Lafayette Square Station to get around town.

Elmwood Village

Travelers come to Elmwood Village for its live music, and you can see top attractions like Blue Sky Mausoleum and Ujima Theatre Company while you're in town.

Delaware Park showing a lake or waterhole

North Buffalo

The live music and zoo are just a few things visitors like about North Buffalo. Buffalo Zoo and Buffalo History Museum are worthwhile spots to check out, and you can hop on the metro at Amherst Street Station or Lasalle Station to get around the larger area.

Allentown

Embracing bohemian and hipster culture, this artistic community offers vibrant nightlife, diverse dining, and antique shopping. Explore the Allentown Historic District, including the renowned Kleinhans Music Hall.

Top East Seneca Hotel Reviews

M Hotel Buffalo

M Hotel Buffalo

10/10 Excellent
"Amazing "
Krystian 2-night trip
Posted 4 hours ago
M Hotel Buffalo

Frequently asked questions

What is East Seneca like?
Travelers will be sure to enjoy their time in West Seneca's East Seneca neighborhood.
If I need to cancel my hotel reservation in East Seneca, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals available in East Seneca.
Where can I learn more about changing or cancelling my trip to East Seneca?
For more information about updating your trip to East Seneca or cancelling it, go to https://www.expedia.com/service/.
What is there to do in this West Seneca neighborhood?
A few places to visit in the area around East Seneca include Southgate Plaza, Harvest Hill Golf Course, and Charles E. Burchfield Nature and Art Center. You might also plan a visit to Enjoy The Journey Art Gallery when you're sightseeing in West Seneca.