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Find hotels in Panacea, FL from ₩130,035

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Compare 515 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Panacea hotels

The Panacea Motel

2.0 star property
9.0 out of 10, Wonderful, (116)
"A v nice place to stay "
The price is ₩147,629
₩164,606 total
includes taxes & fees
Sep 21 - Sep 22
The Panacea Motel

The Lodge at Wakulla Springs

3.0 star property
9.4 out of 10, Exceptional, (991)
"We love staying here!!"
The price is ₩147,423
₩164,381 total
includes taxes & fees
Sep 23 - Sep 24
The Lodge at Wakulla Springs

Wildwood Inn

3.0 star property
8.6 out of 10, Excellent, (1005)
"Very clean and nice staff!"
The price is ₩163,804
₩188,154 total
includes taxes & fees
Sep 21 - Sep 22
Wildwood Inn

Best Western Wakulla Inn & Suites

2.5 star property
8.8 out of 10, Excellent, (919)
"We absolutely love this venue and stay here when we visit our family every year! "
The price is ₩169,585
₩189,087 total
includes taxes & fees
Oct 2 - Oct 3
Best Western Wakulla Inn & Suites

St James Bay Golf & Pickleball Resort

3.5 star property
9.0 out of 10, Wonderful, (357)
"Property layout to access their amenities was good. "
The price is ₩197,735
₩218,497 total
includes taxes & fees
Sep 21 - Sep 22
St James Bay Golf & Pickleball Resort

The Moorings Hotel and Marina

2.5 star property
8.4 out of 10, Very Good, (36)
"Quaint hotel on marina with old Florida charm. Room was very clean but also very musty - mildew coming from AC unit was overwhelming. Bed was awful - literally lumpy with loose headboard that sounded like an accordion when you moved at all. We wedged towels to shut it up. Almost left to pay to stay at a second hotel. "
The price is ₩189,966
₩209,912 total
includes taxes & fees
Oct 1 - Oct 2
The Moorings Hotel and Marina

Franklin Inn

2.0 star property
7.8 out of 10, Good, (441)
"Food options are close and very good"
The price is ₩117,679
₩130,035 total
includes taxes & fees
Sep 21 - Sep 22
Franklin Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Panacea

Experience relaxing Panacea: its beaches, fishing, wildlife, and more!

Top Panacea Hotel Reviews

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Frequently asked questions

Where is the best place to stay in Panacea?

Expedia customers give high marks to The Panacea Motel. See all available top hotels, or vacation rentals in Panacea.

If I need to cancel my hotel reservation in Panacea, will I receive a refund?

Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.

Where can I learn more about changing or cancelling my trip to Panacea?

For more details about changing or cancelling your trip to Panacea, click here.

What's the best pet-friendly place to stay in Panacea?

The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.

What's the best hotel for staying near Tallahassee Regional Airport (TLH)?

Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.

What's it like to stay in Panacea?

Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 200 hotels and other accommodations to choose from. Find out more about Panacea.

What are the top places to visit in Panacea?

Natural beauty is on display at Mashes Sand Beach, Wilson Beach, and Alligator Point Beach. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Bald Point State Park and Public Beach Access. Check out what more to see and do in Expedia's Panacea guide.

What's the seasonal weather like in Panacea?

The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.