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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for Southeast Missouri hotels with a spa

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,007 reviews)
"Everything was great about the stay!"
United States
Denise
The price is ₩122,209
₩136,844 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Poplar Bluff
A spacious lobby with a reception desk, seating area, and large windows.

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,003 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is ₩120,919
₩136,608 total
includes taxes & fees
Nov 9 - Nov 10
Drury Inn & Suites Poplar Bluff
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (976 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is ₩130,204
₩147,098 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,001 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is ₩134,356
₩151,572 total
includes taxes & fees
Nov 8 - Nov 9
Drury Plaza Hotel Cape Girardeau Conference Center
A modern lounge area with seating arrangements, a kitchen area, and a bar.

5. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (82 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is ₩131,117
₩148,540 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn By Hilton Dexter
A living room with a blue wall, a fireplace, a sofa, and a chair.

6. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (117 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ₩141,273
₩153,776 total
includes taxes & fees
Nov 5 - Nov 6
EC Reed's Mercantile and Hotel
A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

7. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (119 reviews)
"Recomend this location"
United States
Jose
The price is ₩124,493
₩202,482 total
includes taxes & fees
Nov 29 - Nov 30
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

8. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (700 reviews)
"Great property"
United States
John
The price is ₩153,584
₩173,265 total
includes taxes & fees
Nov 9 - Nov 10
The Riverview
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ₩114,590
₩130,420 total
includes taxes & fees
Nov 11 - Nov 12
Tru By Hilton Cape Girardeau
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (890 reviews)
"Breakfast was good."
United States
J
The price is ₩107,361
₩116,191 total
includes taxes & fees
Nov 8 - Nov 9
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

11. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is ₩96,732
₩109,127 total
includes taxes & fees
Nov 9 - Nov 10
Pear Tree Inn Cape Girardeau West
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

12. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,000 reviews)
"Awesome place will be staying in more of them"
United States
Tim
The price is ₩126,293
₩145,205 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Sikeston, MO
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

13. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ₩133,209
₩151,609 total
includes taxes & fees
Dec 2 - Dec 3
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

14. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotel…!!"
United States
Carlos
The price is ₩135,914
₩153,330 total
includes taxes & fees
Nov 12 - Nov 13
Fairfield Inn & Suites by Marriott Cape Girardeau
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

15. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is ₩165,677
₩180,968 total
includes taxes & fees
Nov 5 - Nov 6
Shepherd Mountain Inn
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

16. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is ₩131,117
₩147,919 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Cape Girardeau I 55 East
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

17. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (22 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
United States
Misty
The price is ₩150,950
₩172,612 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites By Hilton Festus
A spacious living room with a sofa set, a coffee table, and a dining area.

18. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (556 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is ₩156,002
₩176,771 total
includes taxes & fees
Nov 15 - Nov 16
Courtyard by Marriott Cape Girardeau Downtown
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

19. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,000 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is ₩95,536
₩106,971 total
includes taxes & fees
Nov 18 - Nov 19
Motel 6 Poplar Bluff, MO
Property amenity

20. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (29 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is ₩141,625
₩161,063 total
includes taxes & fees
Nov 15 - Nov 16
TownePlace Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Best breakfast I’ve had in a long time at a hotel. The variety was nice too!"
Lafonzel A 2-night trip
Posted 4 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center