The Best Resorts & Hotels with Spas in Southeast Missouri, MO from ₩156,937 in 2026 | Expedia

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight

Sep 24 - Sep 25

Tomorrow

Sep 25 - Sep 26

This weekend

Sep 25 - Sep 27

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Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.

₩137,890

₩156,937 total

includes taxes & fees

Oct 4 - Oct 5

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Choose what matters most at spa hotels in Southeast Missouri

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent

"Clean room, staff"

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