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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight
Sep 11 - Sep 12
Tomorrow
Sep 12 - Sep 13
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Southeast Missouri hotels with a spa

Exterior
Suite, 1 King Bed
Breakfast area
Indoor pool

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
₩136,335
₩155,168 total
includes taxes & fees
Sep 20 - Sep 21
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southeast Missouri Hotel Reviews

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