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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for Southeast Missouri hotels with a spa

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Everything was great about the stay!"
United States
Denise
The price is ₩120,192
₩134,585 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn Poplar Bluff
A spacious lobby with a reception desk, seating area, and large windows.

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is ₩120,045
₩135,620 total
includes taxes & fees
Nov 8 - Nov 9
Drury Inn & Suites Poplar Bluff
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (975 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is ₩129,263
₩146,034 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is ₩133,385
₩150,477 total
includes taxes & fees
Nov 8 - Nov 9
Drury Plaza Hotel Cape Girardeau Conference Center
A modern hotel lobby with a central dining area, a minibar, and a view of the outdoors.

5. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (81 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is ₩130,170
₩147,467 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn By Hilton Dexter
A living room with a blue wall, a fireplace, a sofa, and a chair.

6. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (117 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ₩140,252
₩152,664 total
includes taxes & fees
Nov 3 - Nov 4
EC Reed's Mercantile and Hotel
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,003 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is ₩96,033
₩108,338 total
includes taxes & fees
Nov 8 - Nov 9
Pear Tree Inn Cape Girardeau West
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (890 reviews)
"Breakfast was good."
United States
J
The price is ₩106,585
₩115,351 total
includes taxes & fees
Nov 8 - Nov 9
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

9. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (699 reviews)
"Clean, quiet, comfortable room. Very comfortable beds."
United States
Renee
The price is ₩152,473
₩172,011 total
includes taxes & fees
Nov 3 - Nov 4
The Riverview
A modern retail area with a display of local items and snacks.

10. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ₩119,231
₩135,702 total
includes taxes & fees
Nov 8 - Nov 9
Tru By Hilton Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

11. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ₩132,064
₩150,306 total
includes taxes & fees
Nov 30 - Dec 1
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

12. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,001 reviews)
"Clean room affordable and great breakfast I would definitely go back!"
United States
Lyn
The price is ₩106,705
₩112,814 total
includes taxes & fees
Nov 8 - Nov 9
Drury Inn & Suites Jackson MO
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

13. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (239 reviews)
"Great hotel…!!"
United States
Carlos
The price is ₩134,932
₩152,222 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites by Marriott Cape Girardeau
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (856 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is ₩130,170
₩146,850 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn Cape Girardeau I 55 East
A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

15. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (118 reviews)
"Recomend this location"
United States
Jose
The price is ₩117,390
₩193,971 total
includes taxes & fees
Dec 1 - Dec 2
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

16. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (337 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is ₩164,480
₩179,661 total
includes taxes & fees
Nov 3 - Nov 4
Shepherd Mountain Inn
A spacious living room with a sofa set, a coffee table, and a dining area.

17. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (556 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is ₩154,875
₩175,495 total
includes taxes & fees
Nov 15 - Nov 16
Courtyard by Marriott Cape Girardeau Downtown
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

18. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,004 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is ₩94,846
₩106,198 total
includes taxes & fees
Nov 15 - Nov 16
Motel 6 Poplar Bluff, MO
A spacious cafe with wooden tables and chairs, large windows, and a bar area.

19. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (801 reviews)
"Always an enjoyable stay"
United States
Nathan
The price is ₩112,054
₩126,593 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Poplar Bluff by IHG
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

20. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (22 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
United States
Misty
The price is ₩152,047
₩173,866 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn & Suites By Hilton Festus
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"I did a surprise overnight for my husband’s birthday! I mainly just wanted to have access to the indoor pool and hot tub! The kick back was great, breakfast was ok! We aren’t big breakfast people. We love that the staff remembered us from last year when we stayed for a week during our home renovations. Room was very clean and the beds are always very comfortable, linens were soft and very clean! We will always have our staycation at the drury"
Robin 1-night trip
Posted 18 hours ago
Drury Inn & Suites Jackson MO
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Fab place, staff were great,very helpful. Friendly sit, will return"
ray 3-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau