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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Our top choices for Southeast Missouri hotels with a spa

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Easy check in and room was very clean. The food for breakfast and dinner is the bomb."
United States
Melody
The price is ₩134,302
₩151,512 total
includes taxes & fees
Nov 15 - Nov 16
Drury Plaza Hotel Cape Girardeau Conference Center

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
"Great place to stay!"
United States
Tiffany
The price is ₩126,243
₩145,147 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Sikeston, MO

3. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,020 reviews)
"Everything was great about the stay!"
United States
Denise
The price is ₩119,226
₩133,504 total
includes taxes & fees
Dec 6 - Dec 7
Hampton Inn Poplar Bluff

4. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (978 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is ₩129,445
₩146,241 total
includes taxes & fees
Dec 6 - Dec 7
Fairfield Inn & Suites by Marriott Poplar Bluff

5. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (201 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ₩114,544
₩130,367 total
includes taxes & fees
Nov 18 - Nov 19
Tru By Hilton Cape Girardeau

6. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ₩141,216
₩153,714 total
includes taxes & fees
Nov 15 - Nov 16
EC Reed's Mercantile and Hotel

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (242 reviews)
"Everything is very clean. Excellent facility all around. Friendly staff"
United States
Dane
The price is ₩135,860
₩153,268 total
includes taxes & fees
Nov 19 - Nov 20
Fairfield Inn & Suites by Marriott Cape Girardeau

8. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (85 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is ₩130,353
₩147,674 total
includes taxes & fees
Dec 10 - Dec 11
Hampton Inn By Hilton Dexter

9. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,001 reviews)
"The lady's that works there are wonderful, and of course the breakfast was amazing!!"
United States
Livia
The price is ₩96,693
₩109,084 total
includes taxes & fees
Nov 16 - Nov 17
Pear Tree Inn Cape Girardeau West

10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (896 reviews)
"Very clean and every one very nice and helpful"
United States
richard
The price is ₩107,318
₩116,145 total
includes taxes & fees
Nov 15 - Nov 16
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

11. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (860 reviews)
"Staff was friendly and helpful. Rooms and facilities were clean."
United States
Britney
The price is ₩131,065
₩147,860 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Cape Girardeau I 55 East

12. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville
3.0 star property
Hayti
9.2 out of 10, Wonderful, (1,001 reviews)
"The food & drinks were great & the staff was very friendly. Room was very nice."
United States
Cynthia
The price is ₩131,615
₩150,008 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Hayti Caruthersville

13. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (703 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is ₩153,522
₩173,195 total
includes taxes & fees
Nov 15 - Nov 16
The Riverview

14. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is ₩165,610
₩180,895 total
includes taxes & fees
Nov 13 - Nov 14
Shepherd Mountain Inn

15. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ₩126,907
₩144,437 total
includes taxes & fees
Dec 11 - Dec 12
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

16. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (559 reviews)
"Good stay"
United States
Kelly
The price is ₩155,940
₩176,702 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard by Marriott Cape Girardeau Downtown

17. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is ₩147,747
₩168,025 total
includes taxes & fees
Nov 19 - Nov 20
Fairfield Inn & Suites by Marriott Sikeston

18. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,000 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is ₩83,409
₩93,396 total
includes taxes & fees
Nov 26 - Nov 27
Motel 6 Poplar Bluff, MO

19. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (29 reviews)
"Good location, updated hotel!"
United States
Shanna
The price is ₩152,261
₩174,110 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn & Suites By Hilton Festus

20. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.6 out of 10, Exceptional, (14 reviews)
"Great place to stay"
United States
Matt
The price is ₩117,823
₩134,879 total
includes taxes & fees
Dec 8 - Dec 9
The Atrium - A Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews