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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight
Sep 23 - Sep 24
Tomorrow
Sep 24 - Sep 25
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
₩136,885
₩155,795 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 23 hours ago
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Great stay, clean rooms, excellent breakfast! Will stay again if we are in the area."
Derek 1-night trip
Posted 2 days ago
Drury Inn & Suites Hayti Caruthersville

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