Search Guest Houses in Southern Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Feb 27 - Mar 1
In two weeks
Mar 6 - Mar 8
In one month
Mar 20 - Mar 22
In two months
Apr 17 - Apr 19

Our top choices for Southern Illinois guest houses

Front of property

Grand Center Inn

Grand Center Inn
3.0 star property
Grand Center
9.4 out of 10, Exceptional, (75 reviews)
"Clean room. Excellent host Eric! Historic home Eric very attentive and helpful with all tips about St. Louis!"
United States
Pamela
The price is ₩258,444
₩304,780 total
includes taxes & fees
Feb 18 - Feb 19
Grand Center Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southern Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"One of the better hotels I have stayed at! Super clean. Great service! Good food options! Liked the evening and breakfast offerings. Very pet friendly. Safe and secure!"
Richard 1-night trip
Posted 16 hours ago
Drury Plaza Hotel Mt. Vernon

Find out more about Southern Illinois

Southern Illinois Guest Houses information

Number of reviews
75
Accommodation
1 Guest Houses
Lowest Price
₩304,780
Highest Price
₩304,780