Clayton, MO

St. Louis

The illuminated Gateway Arch at night with a city skyline in the background.
A city skyline with a prominent arch bridge reflecting on the water.
A city skyline with a prominent arch bridge at sunset.
A gazebo with a green roof, surrounded by a pond, with red and green foliage in the background.
A historic building with a courtyard, surrounded by lush green grass and trees.

Stay near popular Clayton attractions

Washington University in St. Louis

8.8/10 (1,777 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
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Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ₩142,476 per night from Aug 9 to Aug 10
₩142,476
₩166,324 total
Aug 9 - Aug 10
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,300 reviews)
"We had a string of negative experiences during our three-night stay. The first night, the air conditioner in the room was rattling very loudly. I called the front desk and they seemed very annoyed to be talking to me, but they offered to get us a new room. The keys they gave us for the new room didn't ..."

Reviewed on Jul 13, 2026

Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ₩240,792 per night from Jul 19 to Jul 20
₩240,792
₩283,504 total
Jul 19 - Jul 20
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (740 reviews)
"We loved the hotel and all the amenities spent my 5-year wedding anniversary here and will definitely stay here again!"

Reviewed on Jul 9, 2026

Le Méridien St. Louis Clayton
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
The price is ₩195,421 per night from Jul 26 to Jul 27
₩195,421
₩230,085 total
Jul 26 - Jul 27
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the helpful staff ...
8.8/10 Excellent! (1,011 reviews)
"It is nice hotel I’m so beautiful area! The neighborhood is so great! I was walking all my free time. Lively hotel, very clean and comfortable. Will definitely stay here next time"

Reviewed on Jul 13, 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
The price is ₩208,342 per night from Aug 2 to Aug 3
₩208,342
₩243,213 total
Aug 2 - Aug 3
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Saint Louis ...
9.2/10 Wonderful! (339 reviews)
"Amazing"

Reviewed on Jul 12, 2026

AC Hotel St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ₩214,487 per night from Jul 17 to Jul 18
₩214,487
₩252,943 total
Jul 17 - Jul 18
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (4,244 reviews)
"So perfectly located to all downtown attractions."

Reviewed on Jul 13, 2026

Hyatt Regency St. Louis at The Arch
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ₩155,870 per night from Jul 26 to Jul 27
₩155,870
₩203,620 total
Jul 26 - Jul 27
includes taxes & fees
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,218 reviews)
"Great hotel"

Reviewed on Jul 13, 2026

Hollywood Casino & Hotel St. Louis
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A modern building with a brick facade, parked cars, and a flower bed with tulips.

Central West End

The ample dining options and lush forests are just a few popular features of the neighborhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

An ornate hall with arched ceilings and intricate patterns.
Photo by Terry Eaves
Open Photo by Terry Eaves

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

A historic brick building with arched doorways and a sign that reads "Hot Goods Pen House."

St. Charles Historic District

St. Charles Historic District is known for its abundant dining options, and you can plan a trip to Historic Main Street and Missouri River while you're in town.

Clayton, MO