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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

5.6/10 (848 reviews)

It was a place to lay our heads is all I can say on the positive. It was highly outdated needed up, kept in the worst ways. The fixtures in the tub were completely stained and tarnished. It honestly needs a major renovation.

Reviewed on Apr 28, 2026

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

8/10 Very Good! (1,000 reviews)

Floors and windows in room were dirty.. terrible lighting TERRIBLE!!!

Reviewed on Apr 27, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

See all 663 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.