Southeast Missouri Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ₩1,660,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top Luxury Southeast Missouri Hotels
Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
- 3 hours drive from Mark Twain National Forest
Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
- 3 hours drive from Mark Twain National Forest
Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
- 4 hours drive from Mark Twain National Forest
Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.
7.2/10 Good! (1,000 reviews)
"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."
Reviewed on Sep 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
