South Carolina Midlands Beach Vacations
Book a Beach Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to ₩234,741 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top Beach South Carolina Midlands Hotels
Lake Murray Resort & Marina
101 Sandalwood Drive, Leesville, SC
Enjoy sunsets on the beach in Leesville, as you'll be a short walk from a private beach when booking a stay at this hotel. Amenities at Lake Murray Resort & ...
Travelers like: on the beach, cabanas
Travelers say...
"Everything was nice with the exception of restaurant hours being inconsistent, and one of the bed sheets being unclean."
Reviewed on Sep 6, 2018
Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"Easy access to everything needed. Staff and house keeping are exceptional. Sheets, pillows are awesome, Quiet and safe feeling."
Reviewed on Aug 11, 2025
The Inn at the Crossroads
128 West Main Street, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (759 reviews)
"Bar was closed due to remodeling. Not mentioned in online amenities"
Reviewed on Aug 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.