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Top Pet-friendly South Carolina Midlands Hotels

La Quinta Inn & Suites by Wyndham Florence

2123 W Lucas St Florence SC

3 hours drive from Fort Jackson

This pet-friendly hotel welcomes dogs and cats (fees apply).

7.8/10 Good! (1,569 reviews)

"Very rude night staff. Stains and hair on bed sheets, the floors were greasy, furniture was beat up, chair in room had paint stain. The pictures of the room showed two queen size beds and a sofa bed. Front staff said the pictures are wrong and it’s a room with two queen size beds only. I booked it ..."

Reviewed on Jun 30, 2026

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

7333 Garners Ferry Rd Columbia SC

9 min drive from Fort Jackson

This pet-friendly hotel welcomes dogs and cats (fees apply).

8.2/10 Very Good! (1,011 reviews)

"The staff was so kind and polite"

Reviewed on Jun 29, 2026

Hampton Inn Columbia I-26/Harbison Blvd.

101 Woodcross Dr Columbia SC

31 min drive from Fort Jackson

Hiking and biking trails are ready for you to explore near this lakefront hotel, where dogs and cats can stay for an additional fee.

9.2/10 Wonderful! (1,004 reviews)

"Right off the freeway, close to restaurants & continental breakfast"

Reviewed on Jun 28, 2026

See all 3,280 properties in South Carolina Midlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.