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Sep 18 - Sep 19
Tomorrow
Sep 19 - Sep 20
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

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Our top choices for Byron hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
Rochester
United States
Vickie
₩168,761
₩194,285 total
includes taxes & fees
Oct 3 - Oct 4
Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Hampton Inn Rochester-South

Hampton Inn Rochester-South
Rochester
United States
dennis
₩146,109
₩168,208 total
includes taxes & fees
Sep 30 - Oct 1
Hampton Inn Rochester-South

3. Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
Kutzky Park
United States
Jose
₩98,621
₩113,538 total
includes taxes & fees
Sep 20 - Sep 21
Med City Inn & Suites - Mayo Clinic Area

4. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
Rochester
United States
JOSEPH
₩106,723
₩122,865 total
includes taxes & fees
Oct 18 - Oct 19
Comfort Inn & Suites Rochester South Mayo Clinic

5. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Vicky
₩130,626
₩150,383 total
includes taxes & fees
Sep 25 - Sep 26
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

6. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Rochester
United States
Osric
₩96,287
₩110,850 total
includes taxes & fees
Sep 22 - Sep 23
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Kutzky Park
United States
Jon
₩155,001
₩178,447 total
includes taxes & fees
Sep 25 - Sep 26
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

8. Brentwood Inn & Suites

Brentwood Inn & Suites
Downtown Rochester
United States
Delton
₩129,492
₩149,078 total
includes taxes & fees
Sep 24 - Sep 25
Brentwood Inn & Suites

9. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Kutzky Park
United States
Janet
₩139,506
₩160,606 total
includes taxes & fees
Sep 26 - Sep 27
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

10. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Historic Southwest
United States
Carrie
₩148,977
₩171,510 total
includes taxes & fees
Sep 29 - Sep 30
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

11. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
Rochester
United States
Jayne
₩107,056
₩123,248 total
includes taxes & fees
Sep 27 - Sep 28
AmericInn by Wyndham Rochester Near Mayo Clinic

12. Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
Rochester
United States
Dr. Tim
₩142,362
₩163,894 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Rochester-North

13. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Rochester
United States
Jason
₩104,492
₩120,297 total
includes taxes & fees
Oct 4 - Oct 5
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

14. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
Rochester
United States
yuan
₩117,223
₩134,954 total
includes taxes & fees
Oct 15 - Oct 16
Comfort Inn & Suites West - Medical Center

15. Staybridge Suites Rochester - Commerce Dr NW by IHG

Staybridge Suites Rochester - Commerce Dr NW by IHG
Rochester
United States
MATTHEW
₩187,502
₩215,863 total
includes taxes & fees
Oct 18 - Oct 19
Staybridge Suites Rochester - Commerce Dr NW by IHG

16. Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
Rochester
United States
Heather
₩182,325
₩209,901 total
includes taxes & fees
Oct 2 - Oct 3
Residence Inn by Marriott Rochester Mayo Clinic Area South

17. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Kutzky Park
United States
MATTHEW
₩169,272
₩194,874 total
includes taxes & fees
Sep 26 - Sep 27
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

18. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
Rochester
United States
Barbara
₩96,397
₩110,977 total
includes taxes & fees
Oct 11 - Oct 12
Econo Lodge Mayo Clinic Area

19. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
Rochester
United States
Melissa
₩129,168
₩148,703 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express Rochester South - Mayo Area by IHG

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Kutzky Park
United States
Breeanna
₩136,251
₩156,858 total
includes taxes & fees
Sep 26 - Sep 27
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
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Stay near popular Byron attractions

Oxbow Park

8.8/10 (5 reviews)
Explore the great outdoors at Oxbow Park, a lovely green space in Byron. Check out the charming coffeehouses or top-notch restaurants in this walkable area.
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East Brookfield Park

After visiting East Brookfield Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.
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High Point Shopping Center

You can search for that perfect souvenir at High Point Shopping Center during your trip to Byron. Amble around the area's parks or experience its art scene.
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Salem Town Hall

After visiting Salem Town Hall, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.
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Salem Glen Winery

You can enjoy a tasting or tour at Salem Glen Winery during your travels to Byron. Amble around the area's parks or experience its art scene.
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Zollman Zoo

Meet the animals who call Zollman Zoo home during your travels in Byron. Amble around the area's parks or experience its art scene.
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Community Center Park

Community Center Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.
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Byron Town Square

You can browse for the perfect souvenirs at Byron Town Square during your trip to Byron. Amble around the area's parks or experience its art scene.
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Top Byron Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent
"Been here many times with appointments for Mayo clinic. They have a great free breakfast and a awesome restaurant on site. Their shuttle does a great job and very accommodating. Thank you for the great service!"
Tim 1-night trip
Posted 2 hours ago
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic

10/10 Excellent
"Staffs were super helpful and nice. Just make sure you let them know to pick you up ahead of the time."
Yukun 3-night trip
Posted 3 hours ago
Comfort Inn & Suites Rochester South Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"This was the most convenient property to Mayo Clinic. Great room. Wonderful breakfast."
Gerald 2-night trip
Posted 11 hours ago
Kahler Inn and Suites - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"We have to visit the Mayo frequently and this was the first time staying at this hotel. The room was a bit small but served our needs. Very clean and well maintained. Perfect location for the Mayo clinic appointment with the ability to park the car in the ramp and walk to everything we needed. Connected to the subway system, many restaurants and shops in the area."
Alisa 1-night trip
Posted 12 hours ago
Kahler Grand Hotel
The Berkman

The Berkman

10/10 Excellent
"Great communication with staff and a friendly shuttle over to Mayo Gonda. Apartment was squeaky clean."
Shanda 2-night trip
Posted 13 hours ago
The Berkman
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent
"Excellent breakfast variety. Automatic doors plus luggage cart available. Ample parking with car visible from the room window. Hotel entrance is somewhat hidden. It is connected to and right behind Famous Daves Restaurant. Multiple restaurants nearby."
John B 1-night trip
Posted 1 day ago
Med City Inn & Suites - Mayo Clinic Area
Aspen Select

Aspen Select

10/10 Excellent
"Room was nice and clean. The staff were nice, efficient and helpful"
Jeff 3-night trip
Posted 1 day ago
Aspen Select
Brentwood Inn & Suites

Brentwood Inn & Suites

10/10 Excellent
"Easy in and out! Affordable."
Ryan 1-night trip
Posted 1 day ago
Brentwood Inn & Suites
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent
"Clean, reasonable hotel. Nice pool, and hot tubs."
Suellen 1-night trip
Posted 1 day ago
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

More cheap stays in Byron

Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN
₩80,168
₩92,295 total
Oct 4 - Oct 5
includes taxes & fees
Birch Hill Suite Rochester – Med City
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN
₩98,621
₩113,538 total
Sep 20 - Sep 21
includes taxes & fees
7.8/10 Good! (1,016 reviews)
Med City Inn & Suites - Mayo Clinic Area
Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN
₩106,723
₩122,865 total
Oct 18 - Oct 19
includes taxes & fees
8.8/10 Excellent! (1,002 reviews)
Comfort Inn & Suites Rochester South Mayo Clinic
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN
₩129,168
₩148,703 total
Oct 18 - Oct 19
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
Holiday Inn Express Rochester South - Mayo Area by IHG
Brentwood Inn & Suites

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN
₩129,492
₩149,078 total
Sep 24 - Sep 25
includes taxes & fees
8.8/10 Excellent! (1,004 reviews)
Brentwood Inn & Suites
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN
₩130,626
₩150,383 total
Sep 25 - Sep 26
includes taxes & fees
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Frequently asked questions

Where is the best place to stay in Byron?
Located 9.3 mi (14.9 km) from the heart of Byron, AmericInn by Wyndham Rochester Near Mayo Clinic is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
Where can I learn more about changing or cancelling my trip to Byron?
To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.
Where is the best place to stay near Oxbow Park?
Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 3 hotels and other accommodations to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favorite places to visit include Oxbow Park, Links of Byron Mini Golf, and Cheery Meadows Center. A couple of additional sights to add to your agenda are High Point Shopping Center and Byron Town Square. Check out what more to see and do in Expedia's Byron guide.
What's the weather like in Byron?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.

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