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Compare 99 hotels in Mississippi County with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Mississippi County hotels

Super 8 by Wyndham Charleston/Sikeston East MO
Front of property - evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (592)
"Rooms was clean "
The price is ₩79,995
₩88,788 total
includes taxes & fees
Sep 28 - Sep 29
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (403)
"I consistently choose to stay there due to positive past encounters."
The price is ₩92,286
₩102,416 total
includes taxes & fees
Oct 6 - Oct 7
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Desk, iron/ironing board, free WiFi, alarm clocks

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (101)
"Comfortable bed, easy access to room"
The price is ₩89,603
₩99,450 total
includes taxes & fees
Sep 28 - Sep 29
Eagle Inn Charleston
Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (268)
"The room smelled like pee and the carpets, hallway and room were filthy. The shower was filthy with paint peeling and mold on the ceiling "
The price is ₩95,447
₩105,927 total
includes taxes & fees
Oct 14 - Oct 15
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Always a nice place to stay!"
Joe 1-night trip
Posted 5 days ago
Drury Inn & Suites Sikeston, MO

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