Photo by Carmen Bustin-Dinning

Find Business Hotels in Duck Key, FL

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Duck Key Business Hotels

Tonight
Dec 24 - Dec 25
Tomorrow
Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Duck Key business-friendly hotels

Exterior
Lime Tree Bay Resort

Lime Tree Bay Resort

Lime Tree Bay Resort
3.5 star property
Long Key
9.2 out of 10, Wonderful, (1110)
"Great place "
United States
Oscar
Lime Tree Bay Resort
2 outdoor pools, free cabanas, pool umbrellas
Courtyard by Marriott Faro Blanco Resort, Marathon Florida Keys

Courtyard by Marriott Faro Blanco Resort, Marathon Florida Keys

Courtyard by Marriott Faro Blanco Resort, Marathon Florida Keys
3.0 star property
Marathon
9.0 out of 10, Wonderful, (1000)
"Food great. Grounds kept prestine"
United States
Donald
The price is ₩365,483
₩469,424 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott Faro Blanco Resort, Marathon Florida Keys
Property grounds
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1067)
"Beautiful property, staff are very friendly "
United States
Leann
The price is ₩456,410
₩607,102 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Isla Bella Beach Resort & Spa
Property amenity
Fairfield Inn & Suites by Marriott Marathon Florida Keys

Fairfield Inn & Suites by Marriott Marathon Florida Keys

Fairfield Inn & Suites by Marriott Marathon Florida Keys
2.5 star property
Marathon
9.2 out of 10, Wonderful, (1051)
"Great staff, clean room, good breakfast "
United States
Kelly
The price is ₩324,052
₩364,566 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Marathon Florida Keys
4 outdoor pools, pool umbrellas, sun loungers
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
4.0 star property
Marathon
8.8 out of 10, Excellent, (1270)
"Very nice resort. All the staff was friendly and helpful. The pool bar was great and the bartender was friendly. Our favorite place to stay in Marathon."
United States
William
The price is ₩413,253
₩519,249 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Outdoor pool, pool umbrellas, sun loungers
Hampton Inn Marathon - Florida Keys

Hampton Inn Marathon - Florida Keys

Hampton Inn Marathon - Florida Keys
2.5 star property
Marathon
9.0 out of 10, Wonderful, (1003)
"Stay is excellent, highly recommended for families "
United States
Srikanth
The price is ₩332,457
₩374,014 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Marathon - Florida Keys
Marina
Skipjack Resort & Marina

Skipjack Resort & Marina

Skipjack Resort & Marina
3.0 star property
Marathon
8.6 out of 10, Excellent, (1218)
"Beautiful location clean rooms friendly staff "
United States
Tiffany
Skipjack Resort & Marina
Front of property
Siesta Motel

Siesta Motel

Siesta Motel
2.0 star property
Marathon
7.4 out of 10, Good, (694)
"Yes beautiful thanks."
United States
Donald
The price is ₩263,174
₩296,069 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Siesta Motel
3 outdoor pools, sun loungers
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1000)
"Great resort with lots of fun things to do. Really enjoyed our stay there. Would highly recommend it."
United Kingdom
Jaskaran
The price is ₩460,934
₩613,076 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Tranquility Bay Beachfront Hotel and Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Duck Key Hotel Reviews

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"Great resort with lots of fun things to do. Really enjoyed our stay there. Would highly recommend it."
Jaskaran 3-night trip
Posted 4 days ago
Tranquility Bay Beachfront Hotel and Resort

Frequently asked questions

How much do business-friendly hotels in Duck Key cost?
You'll pay between ₩296,069 and ₩613,076 per night for business-friendly hotels in Duck Key. Epic deals on stays that cater to corporate travelers as just a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Duck Key?
A lot of corporate travelers recommend Hampton Inn Marathon - Florida Keys. This 2.5-stars property offers amenities such as pool sun loungers and a swimming pool. Fairfield Inn & Suites by Marriott Marathon Florida Keys is another highly rated option. It has a 2.5-stars rating and conveniences like a marina and an outdoor entertainment area. You'll have your pick of multiple business-friendly hotels in Duck Key that have a total average guest review rating of 8.7.
How many business-friendly hotels are there in Duck Key?
Duck Key offers 2 hotels that accommodate business travelers. Whether you're searching for a location close to the city center or conveniences such as dependable WiFi and conference rooms, you'll find the perfect property on Expedia.
What are the best cheap business-friendly hotels in Duck Key?
Business-friendly hotels in Duck Key start from only ₩296,069 per night, so your next work-related trip doesn't need to cost a fortune. Hampton Inn Marathon - Florida Keys is a reasonably priced choice that comes with plenty of amenities, like a swimming pool and pool sun loungers. Fairfield Inn & Suites by Marriott Marathon Florida Keys is another budget-minded stay that's favored by corporate guests. Conveniences here include individually decorated rooms and a terrace. If you're looking to get some sightseeing done during your Duck Key business trip, there are plenty of free attractions to add to your itinerary. Coco Plum Beach and Captain Hooks Marina and Dive Center are visitor favorites. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Duck Key that are also business friendly?
Hawks Cay Resort is a top pick for family and corporate travelers. A playground and a children's pool are among the many amenities at this 4-stars Duck Key escape. Once you've finished work, there are plenty of family-friendly attractions to explore around Duck Key. Coco Plum Beach and Florida Keys Aquarium Encounters guarantee fun for young and old.
Why book your business-friendly hotel in Duck Key with Expedia?
With top amenities like meeting rooms, 24-hour room service and free parking, our business-friendly stays come with everything you'll need to complete the job — and then relax in the comfort of your room. Enter your destination and preferred travel dates and Expedia will help you do the rest.
How can I find cheap business-friendly hotels in Duck Key?
When work takes you on the road in Duck Key, our "business friendly" filter will help you find the right hotel. From fast WiFi to computer stations and concierge services, they come with the amenities you need for a productive and comfortable stay. You can also narrow your search by your budget and preferred star rating to view the most affordable properties.
What is there to do in Duck Key near my business-friendly hotel?
Whatever you're interested in, Duck Key has tons of things to keep you hopping. Coco Plum Beach, Curry Hammock State Park and Florida Keys Aquarium Encounters are on many visitors' sightseeing plans. Don't forget about Captain Hooks Marina and Dive Center, San Pablo Catholic Church and Dolphin Research Center either. With Expedia's business-friendly hotel deals, you'll be able to see more renowned attractions like these with the cash you save.