The Best Hotels Closest to Mayo Clinic Hospital - Saint Marys Campus in Rochester for 2026

An aerial view of a campus with multiple buildings, parking lots, and surrounding greenery.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Hospital - Saint Marys Campus hotels

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 0.9 km from Mayo Clinic Hospital - Saint Marys Campus

Jon

₩154,414

₩177,769 total

includes taxes & fees

Sep 25 - Sep 26

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A modern hotel entrance with a glass facade, illuminated signage, and a covered walkway.

A modern indoor swimming pool with seating areas and a city view.

2. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Jennifer

₩237,370

₩273,272 total

includes taxes & fees

Sep 4 - Sep 5

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 1 km from Mayo Clinic Hospital - Saint Marys Campus

Jorge

₩175,901

₩202,507 total

includes taxes & fees

Sep 4 - Sep 5

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern restaurant with a counter, seating area, and a TV screen.

A modern hotel room with a bed, desk, and kitchenette.

4. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.3 km from Mayo Clinic Hospital - Saint Marys Campus

Vickie

₩169,053

₩194,624 total

includes taxes & fees

Sep 11 - Sep 12

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.3 km from Mayo Clinic Hospital - Saint Marys Campus

Richard

₩189,559

₩218,229 total

includes taxes & fees

Sep 11 - Sep 12

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

6. The Berkman

Folwell, 0.1 km from Mayo Clinic Hospital - Saint Marys Campus

William

₩283,300

₩329,414 total

includes taxes & fees

Sep 1 - Sep 2

A modern indoor patio with a fire feature, seating, and large windows.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 0.4 km from Mayo Clinic Hospital - Saint Marys Campus

paul

₩145,282

₩185,961 total

includes taxes & fees

Sep 11 - Sep 12

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 0.4 km from Mayo Clinic Hospital - Saint Marys Campus

Marissa

₩142,660

₩167,008 total

includes taxes & fees

Sep 4 - Sep 5

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A conference room with a long table, multiple chairs, and decorative wall art.

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 0.2 km from Mayo Clinic Hospital - Saint Marys Campus

MATTHEW

₩156,421

₩180,080 total

includes taxes & fees

Sep 18 - Sep 19

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

A gym with exercise equipment, a clock, and a window with blinds.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 0.2 km from Mayo Clinic Hospital - Saint Marys Campus

Lin

₩157,707

₩181,560 total

includes taxes & fees

Sep 11 - Sep 12

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

11. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Camille

₩234,043

₩269,442 total

includes taxes & fees

Sep 4 - Sep 5

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A reception area with a clock, a counter, and a nameplate.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.9 km from Mayo Clinic Hospital - Saint Marys Campus

Sean

₩160,502

₩184,777 total

includes taxes & fees

Aug 29 - Aug 30

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

13. Hampton Inn Rochester-South

3.1 km from Mayo Clinic Hospital - Saint Marys Campus

Lynne

₩146,472

₩168,626 total

includes taxes & fees

Sep 24 - Sep 25

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern indoor pool area with lounge chairs and a pool.

A modern bar area with seating and a counter.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

14. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 1.6 km from Mayo Clinic Hospital - Saint Marys Campus

Bridgett

₩192,522

₩221,641 total

includes taxes & fees

Aug 28 - Aug 29

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A hotel room with a large bed, a TV, a bathroom with a sink and mirror, and a window with curtains.

15. Aspen Suites

0.2 km from Mayo Clinic Hospital - Saint Marys Campus

CASEY

₩196,172

₩237,142 total

includes taxes & fees

Aug 28 - Aug 29

A modern lobby with a reception desk, a green sofa, and a black spherical table.

A modern hotel with a prominent 'Hotel Indigo' sign, a 'Crave Drink' restaurant, and a well-lit facade.

A modern bar area with a central island, bar stools, and hanging spherical light fixtures.

An indoor dining area with wooden ceiling beams, large windows, and modern furniture.

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Kyle

₩128,679

₩148,147 total

includes taxes & fees

Sep 12 - Sep 13

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A reception area with a curved counter, ceiling lights, and a potted plant.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

17. Brentwood Inn & Suites

Downtown Rochester, 1.3 km from Mayo Clinic Hospital - Saint Marys Campus

Bryan

₩172,955

₩199,120 total

includes taxes & fees

Sep 1 - Sep 2

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A reception area with two counters, a patterned wall, and a wooden floor.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 1.6 km from Mayo Clinic Hospital - Saint Marys Campus

Eileen

₩157,707

₩181,560 total

includes taxes & fees

Sep 12 - Sep 13

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

19. Quality Inn & Suites Mayo Clinic Area

2.9 km from Mayo Clinic Hospital - Saint Marys Campus

Cassandra

₩105,848

₩123,352 total

includes taxes & fees

Sep 4 - Sep 5

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 1.2 km from Mayo Clinic Hospital - Saint Marys Campus

Sarah

₩158,011

₩181,910 total

includes taxes & fees

Aug 29 - Aug 30

View all properties

Compare popular hotels close to Mayo Clinic Hospital - Saint Marys Campus

Property	Property class	Guest rating
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 737 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 641 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 553 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 301 reviews	View

Top Mayo Clinic Hospital - Saint Marys Campus Hotel Reviews

Aspen Suites

10/10 Excellent

"I have stayed here before and the staff is always wonderful. The breakfast and evening light dinner is helpful. The room and hotel was clean."

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent

"We stayed here 4 nights while visiting family and it was better than expected. Pros: room was clean, did not stink, the a/c worked very well, bed was comfy, had good water pressure in the shower and water actually got hot (and rapidly). . Pool was clean, hot tub was clean (jets worked!) and palm tree water feature in kiddie pool worked. Everything at breakfast was in working order and stocked, and they even had non-dairy creamers (Coffee mate). Located next to walking trail. Easy check in and out. Temperature controlled stairwell! Quiet hallway. Cons: found a used washcloth tangled in the shower curtain our first time using it (removed by housekeeping), tub drained very slowly, and when asked, front desk didn't know how much arcade games actually cost (price posted was 50¢, but first game cost $1, took $3 before could play second game). The only true drawback was the tub and the pros definitely outweighed it. Would definitely stay here again!"

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"nothing great"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"There is free breakfast each morning and free dinner Monday-Wednesday. Nothing fancy. Not safe for those with Celiac though. The gym is excellent. The courtyard is comfortable. The staff lights fire pits outside in the evening."

Brentwood Inn & Suites

10/10 Excellent

"A comfortable stay close by Mayo Clinic"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"We loved our stay! Staff was excellent, we will be back"

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

8/10 Good

"The bathroom toilets were low"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"Great staff"

Frequently asked questions

What's the area like around Mayo Clinic Hospital - Saint Marys Campus?

Mayo Clinic Hospital - Saint Marys Campus is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 126 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Mayo Clinic Hospital - Saint Marys Campus?

Adjacent to Mayo Clinic Hospital - Saint Marys Campus, EVEN Hotel Rochester - Mayo Clinic Area by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an indoor pool. Other good options within a short distance include Kahler Grand Hotel and Med City Inn & Suites - Mayo Clinic Area.

How many hotels should I expect to find close to Mayo Clinic Hospital - Saint Marys Campus?

Expedia has 126 hotels and other accommodations within a mile from Mayo Clinic Hospital - Saint Marys Campus.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Hospital - Saint Marys Campus, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Add dates, click "Search", then you can filter by "fully refundable" to get top deals close to Mayo Clinic Hospital - Saint Marys Campus.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Hospital - Saint Marys Campus?

To find more details about changing or cancelling your stay near Mayo Clinic Hospital - Saint Marys Campus, go to https://www.expedia.com/service/.

What can I see and do near Mayo Clinic Hospital - Saint Marys Campus?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Sights like Plummer House and Assisi Heights highlight some of the local culture. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Find hotels near Mayo Clinic Hospital - Saint Marys Campus, Rochester from ₩123,352

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Hospital - Saint Marys Campus hotels

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

2. Hilton Rochester Mayo Clinic Area

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

4. Home2 Suites by Hilton Rochester Mayo Clinic Area

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. The Berkman

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Broadway Plaza, Trademark Collection by Wyndham

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

13. Hampton Inn Rochester-South

14. Hyatt House Rochester/Mayo Clinic Area

15. Aspen Suites

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

17. Brentwood Inn & Suites

18. Hilton Garden Inn Rochester Downtown, MN

19. Quality Inn & Suites Mayo Clinic Area

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Compare popular hotels close to Mayo Clinic Hospital - Saint Marys Campus

Top Mayo Clinic Hospital - Saint Marys Campus Hotel Reviews

Aspen Suites

Med City Inn & Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Brentwood Inn & Suites

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Frequently asked questions