Find hotels in Medical Center District, San Antonio

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Medical Center District hotels

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,000 reviews)
"clean room staff was very friendly, breakfast was amazing!!"
United States
Drew
The price is ₩149,526
₩174,571 total
includes taxes & fees
May 4 - May 5
Fairfield Inn & Suites by Marriott San Antonio Medical Center

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,002 reviews)
"Perfect place to stay comfy and clean delicious food good staff thank you much."
United States
Iris Grisell
The price is ₩149,050
₩177,112 total
includes taxes & fees
May 3 - May 4
San Antonio Marriott Northwest Medical Center

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3,236 reviews)
"Hotel was clean , and staff were very friendly. "
United States
Alyssa
The price is ₩123,850
₩146,400 total
includes taxes & fees
May 1 - May 2
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,290 reviews)
"Had a great stay. "
United States
MARY
The price is ₩135,917
₩160,665 total
includes taxes & fees
Apr 8 - Apr 9
Drury Inn & Suites San Antonio Northwest Medical Center

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,002 reviews)
"Clean, helpful staff. "
United States
Edna
The price is ₩148,015
₩174,967 total
includes taxes & fees
Apr 30 - May 1
Courtyard by Marriott Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (230 reviews)
"Staff was courteous and professional and the room is nice."
United States
Thomas
The price is ₩84,123
₩108,787 total
includes taxes & fees
Apr 27 - Apr 28
OYO Inn & Suites Medical Center San Antonio

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (518 reviews)
"It was a comfortable stay. No roaches or bed bugs at affordable prices "
United States
FrankR
The price is ₩63,888
₩75,518 total
includes taxes & fees
Apr 12 - Apr 13
Flex Studios

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1,001 reviews)
"Great stay "
United States
Jody
The price is ₩96,225
₩112,344 total
includes taxes & fees
May 4 - May 5
Park Inn by Radisson

Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (852 reviews)
"Very good location , clean rooms"
United States
Jose
The price is ₩64,175
₩78,871 total
includes taxes & fees
Apr 12 - Apr 13
Studio 6 Extended Stay - San Antonio, TX - Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (999 reviews)
"Room was clean, beds comfortable, staff extremely friendly and helpful "
United States
Kathleen
The price is ₩70,292
₩83,085 total
includes taxes & fees
Apr 11 - Apr 12
Motel 6 San Antonio, TX - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (265 reviews)
"This Hotel is well lit and we felt safe. The staff was outstanding during check in and check out! Room was very clean. We had a very comfortable stay. "
United States
Gilbert
The price is ₩70,851
₩82,707 total
includes taxes & fees
Apr 11 - Apr 12
Studio 6 San Antonio, Tx - Northwest Medical Center

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.6 out of 10, Good, (285 reviews)
"Yes .staff really nice "
United States
jamar
The price is ₩74,763
₩87,285 total
includes taxes & fees
May 4 - May 5
Atria Inn & Suites

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1,000 reviews)
"A good hotel choice. Had a good breakfast. "
United States
Kelsey
The price is ₩92,570
₩108,075 total
includes taxes & fees
Apr 26 - Apr 27
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Spark by Hilton San Antonio Dominion

Spark by Hilton San Antonio Dominion
3.0 star property
19.5 km from Medical Center District
8.8 out of 10, Excellent, (341 reviews)
"Great place to stay"
United States
Ketan
The price is ₩104,034
₩112,097 total
includes taxes & fees
May 3 - May 4
Spark by Hilton San Antonio Dominion

Best Western Garden Inn

Best Western Garden Inn
2.5 star property
Uptown, 21.2 km from Medical Center District
8.2 out of 10, Very Good, (1,004 reviews)
"Friendly Staff, easily find location,"
United States
Hua
The price is ₩106,541
₩124,387 total
includes taxes & fees
May 3 - May 4
Best Western Garden Inn

Hampton Inn & Suites Selma-San Antonio-Randolph AFB Texas

Hampton Inn & Suites Selma-San Antonio-Randolph AFB Texas
2.5 star property
Live Oak, 25 km from Medical Center District
9.2 out of 10, Wonderful, (1,001 reviews)
"Great stay, convenient and comfortable. "
United States
Aaron
The price is ₩126,951
₩145,677 total
includes taxes & fees
Apr 12 - Apr 13
Hampton Inn & Suites Selma-San Antonio-Randolph AFB Texas

Extended Stay America Premier Suites - San Antonio - Schertz

Extended Stay America Premier Suites - San Antonio - Schertz
2.5 star property
29.4 km from Medical Center District
9.2 out of 10, Wonderful, (241 reviews)
"Great parking, calm area and very friendly staff. Would definitely stay again. "
United States
Denise
The price is ₩146,792
₩168,798 total
includes taxes & fees
Apr 17 - Apr 18
Extended Stay America Premier Suites - San Antonio - Schertz

Drury Inn & Suites San Antonio North Stone Oak

Drury Inn & Suites San Antonio North Stone Oak
3.0 star property
Stone Oak, 14.8 km from Medical Center District
9.6 out of 10, Exceptional, (1,381 reviews)
"Clean and staff are friendly!"
United States
Neusa
The price is ₩135,917
₩160,665 total
includes taxes & fees
May 4 - May 5
Drury Inn & Suites San Antonio North Stone Oak

Best Western Plus Downtown North

Best Western Plus Downtown North
2.5 star property
13.4 km from Medical Center District
8.6 out of 10, Excellent, (1,002 reviews)
"Great place to stay!"
United States
Hector
The price is ₩141,204
₩164,856 total
includes taxes & fees
Apr 15 - Apr 16
Best Western Plus Downtown North

Comfort Inn & Suites Texas Hill Country

Comfort Inn & Suites Texas Hill Country
2.5 star property
33.8 km from Medical Center District
8.6 out of 10, Excellent, (1,002 reviews)
"The rooms were clean, everything was well maintained, breakfast was great and the location of the hotel was perfect."
United States
Stephen
The price is ₩144,512
₩163,298 total
includes taxes & fees
Apr 28 - Apr 29
Comfort Inn & Suites Texas Hill Country
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Lobby
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,000 reviews
View
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,290 reviews
View
Lobby
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,002 reviews
View
Bar (on property)
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,002 reviews
View
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very Good
3,236 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Uptown

While visiting Uptown, you might make a stop by sights like San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

Top Medical Center District Hotel Reviews

Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include Fairfield Inn & Suites by Marriott San Antonio Medical Center and Courtyard by Marriott Medical Center San Antonio.
How many hotels will I be able to find in Medical Center District?
Expedia has 119 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
Where can I learn more about changing or cancelling my trip to Medical Center District?
For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute, and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.