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May 22 - May 24
Next weekend
May 29 - May 31

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Our top choices for Medical Center District hotels

Lobby

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,063 reviews)
"The hotel’s location is great. The reception staff was welcoming and friendly, and the rooms are always clean. "
United States
Maria
The price is ₩151,045
₩179,491 total
includes taxes & fees
May 22 - May 23
San Antonio Marriott Northwest Medical Center
Free daily buffet breakfast

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3,355 reviews)
"Great stay"
United States
Edward
The price is ₩132,603
₩156,734 total
includes taxes & fees
May 20 - May 21
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Lobby

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,323 reviews)
"Staff was friendly and check in was very fast. I recommend and will stay there again."
United States
Michael
The price is ₩134,380
₩158,849 total
includes taxes & fees
May 25 - May 26
Drury Inn & Suites San Antonio Northwest Medical Center
Property entrance

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (235 reviews)
"I appropriated their accommodation to give us a bottom floor room (back problems)"
United States
Tonya
The price is ₩70,557
₩89,431 total
includes taxes & fees
Jun 2 - Jun 3
OYO Inn & Suites Medical Center San Antonio
Lobby

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,003 reviews)
"Was a great stay. "
United States
Sunanda
The price is ₩128,422
₩149,933 total
includes taxes & fees
Jun 15 - Jun 16
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Bar (on property)

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,005 reviews)
"Clean, helpful staff. "
United States
Edna
The price is ₩146,341
₩172,988 total
includes taxes & fees
May 26 - May 27
Courtyard by Marriott Medical Center San Antonio
Basic Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (532 reviews)
"Ok place to stay a night or 2 Denny's and mc Donald's are walking distance , rooms are clean beds are ok not sure if a female traveling alone would feel safe , there's no breakfast, "
United States
Santiago
The price is ₩57,790
₩68,314 total
includes taxes & fees
May 20 - May 21
Flex Studios
Desk, laptop workspace, blackout drapes, free WiFi

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (289 reviews)
"Nice place I’m grateful for the price"
United States
Angelo
The price is ₩70,050
₩81,782 total
includes taxes & fees
May 21 - May 22
Studio 6 San Antonio, Tx - Northwest Medical Center
Free daily on-the-go breakfast

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1,002 reviews)
"Is a good place with good parking and service costumer"
United States
Raymond
The price is ₩97,735
₩114,106 total
includes taxes & fees
Jun 2 - Jun 3
Park Inn by Radisson
Free daily on-the-go breakfast

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
7.0 out of 10, Good, (1,000 reviews)
"Great breakfast!"
United States
Eric Allan
The price is ₩87,581
₩102,260 total
includes taxes & fees
May 20 - May 21
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Free WiFi, bed sheets

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1,001 reviews)
"Ok"
Mexico
Andres
The price is ₩66,660
₩78,800 total
includes taxes & fees
May 20 - May 21
Motel 6 San Antonio, TX - Northwest Medical Center
Desk, laptop workspace, free WiFi, bed sheets

Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (897 reviews)
"It was an amazing stay "
United States
Cordale
The price is ₩74,649
₩91,240 total
includes taxes & fees
May 20 - May 21
Studio 6 Extended Stay - San Antonio, TX - Medical Center
Front of property

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.6 out of 10, Good, (291 reviews)
"Yes .staff really nice "
United States
jamar
The price is ₩73,917
₩86,299 total
includes taxes & fees
Jun 15 - Jun 16
Atria Inn & Suites
Exterior

Comfort Inn & Suites Texas Hill Country

Comfort Inn & Suites Texas Hill Country
2.5 star property
33.8 km from Medical Center District
8.8 out of 10, Excellent, (1,005 reviews)
"Nice hotel."
United Kingdom
susan
The price is ₩141,190
₩159,544 total
includes taxes & fees
May 27 - May 28
Comfort Inn & Suites Texas Hill Country
Fireplace

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1,670 reviews)
"Great Stay! "
United States
Candace
The price is ₩249,378
₩356,476 total
includes taxes & fees
May 25 - May 26
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Free daily continental breakfast

Spark by Hilton San Antonio Dominion

Spark by Hilton San Antonio Dominion
3.0 star property
19.5 km from Medical Center District
9.0 out of 10, Wonderful, (410 reviews)
"Clean hotel and friendly staff! I would stay there again. "
United States
Jacob
The price is ₩102,857
₩110,829 total
includes taxes & fees
May 26 - May 27
Spark by Hilton San Antonio Dominion
Standard Studio, 1 King Bed, Refrigerator & Microwave | Premium bedding, laptop workspace, iron/ironing board, free WiFi

Extended Stay America Premier Suites - San Antonio - Schertz

Extended Stay America Premier Suites - San Antonio - Schertz
2.5 star property
29.4 km from Medical Center District
9.0 out of 10, Wonderful, (288 reviews)
"Great parking, calm area and very friendly staff. Would definitely stay again. "
United States
Denise
The price is ₩134,380
₩154,539 total
includes taxes & fees
May 20 - May 21
Extended Stay America Premier Suites - San Antonio - Schertz
Property entrance

Hampton Inn & Suites Schertz

Hampton Inn & Suites Schertz
2.5 star property
31.1 km from Medical Center District
8.8 out of 10, Excellent, (887 reviews)
"Excellent stay! "
United States
Roxanne
The price is ₩121,191
₩139,369 total
includes taxes & fees
Jun 1 - Jun 2
Hampton Inn & Suites Schertz
Lobby

Best Western Plus Atrium Inn

Best Western Plus Atrium Inn
2.5 star property
30.6 km from Medical Center District
8.6 out of 10, Excellent, (1,010 reviews)
"Clean, friendly stores and attractions close by."
United States
Norma
The price is ₩134,828
₩155,053 total
includes taxes & fees
Jun 7 - Jun 8
Best Western Plus Atrium Inn
Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)

Plaza San Antonio Hotel & Spa, Autograph Collection

Plaza San Antonio Hotel & Spa, Autograph Collection
4.0 star property
Downtown San Antonio, 12.9 km from Medical Center District
9.4 out of 10, Exceptional, (812 reviews)
"Beautiful hotel, valet is pricey around $70.00 per night, but other than that we had a great stay. Lots to do in the area and staff was very friendly."
United States
brandee
The price is ₩192,221
₩273,654 total
includes taxes & fees
May 31 - Jun 1
Plaza San Antonio Hotel & Spa, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,323 reviews
View
Lobby
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,003 reviews
View
Bar (on property)
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,005 reviews
View
Lobby
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,063 reviews
View
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very Good
3,355 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

SanAntonio_SanAntonioSeaWorld_502636_04

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Photo by Sarah C.
Open Photo by Sarah C.

Uptown

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Bluebonnet Fields in Texas

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

River Walk in San Antonio, Texas

Fort Sam Houston

One reason travelers love spending time in Fort Sam Houston is the stunning river views, and United States Army Medical Department Museum is a top place to visit.

Top Medical Center District Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

6/10 Okay
"For the amount of money I spent for a three‑day stay, I expected a much cleaner hotel and better‑maintained amenities. The lobby had a strong vinegar odor that was noticeable every time I walked through. While the staff themselves were wonderful and displayed true southern hospitality, the overall presentation of the room was disappointing. By day two, the room developed a strange smell, and several maintenance issues became impossible to ignore. The bathroom vent in Room 510 was extremely dirty with caked‑on dust, and the fan wasn’t working at all. Many of the metal finishes throughout the room were rusted, which added to the feeling that the space wasn’t being properly cared for. I was also charged $10 per day for parking, yet on the day I checked in, multiple cars in that same lot had been broken into and robbed. That did not make me feel secure about leaving my vehicle there. Because of local graduations and the short duration of my trip, relocating wasn’t an option. I also chose not to bring these concerns to the staff during my stay, as I felt doing so would leave me in a vulnerable position while I still had to sleep there for several more nights. Overall, the staff was kind, but the condition of the hotel did not match the price point or expectations."
Alfredo 3-night trip
Posted 2 hours ago
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on our traveler data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include San Antonio Marriott Northwest Medical Center and Courtyard by Marriott Medical Center San Antonio.
How many hotels will I be able to find in Medical Center District?
Expedia has 133 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
Where can I learn more about changing or cancelling my trip to Medical Center District?
For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, Cinemark San Antonio 16, and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.