Top 10 Hotels in Southeast Missouri, MO from ₩83,521 - Competitive Prices

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Michael

₩165,549

₩180,828 total

includes taxes & fees

Oct 16 - Oct 17

A motel with a covered entrance, a flag, and a phone number.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

2. Madison Inn Lodge

Fredericktown

Bawan

₩118,838

₩129,794 total

includes taxes & fees

Oct 17 - Oct 18

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Abram

₩120,006

₩137,228 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

4. Fort Davidson Hotel

Ironton

richard

₩167,831

₩183,325 total

includes taxes & fees

Oct 18 - Oct 19

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

₩130,103

₩146,984 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

A hotel breakfast area with a counter, food dispensers, and a refrigerator.

A gym with treadmills, elliptical machines, and weight equipment.

6. Holiday Inn Express & Suites Perryville by IHG

Perryville

Perry

₩127,552

₩146,015 total

includes taxes & fees

Nov 15 - Nov 16

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

7. Super 8 by Wyndham Farmington

Farmington

Marisa

₩79,888

₩91,351 total

includes taxes & fees

Oct 23 - Oct 24

A spacious lobby with a reception desk, seating area, and large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

8. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

₩126,196

₩142,570 total

includes taxes & fees

Oct 25 - Oct 26

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

9. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

₩135,809

₩155,297 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a nightstand, and a wall-mounted light fixture.

A hotel room with a flat-screen TV, a desk with a chair, a sofa, a small table, and framed pictures on the wall.

A compact kitchen with a microwave, a sink, and a small refrigerator.

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

10. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

₩122,114

₩136,738 total

includes taxes & fees

Nov 1 - Nov 2

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A gym with cardio equipment, a bench press, and a squat rack.

11. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

stewart

₩73,040

₩83,521 total

includes taxes & fees

Nov 1 - Nov 2

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A brick building with a sign reading "Mercantile & Hotel".

12. EC Reed's Mercantile and Hotel

Marble Hill

Miranda

₩141,163

₩153,656 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a sofa, a small table, a chair, a desk, two lamps, a window with curtains, and a framed picture on the wall.

A hotel room with a desk, chair, and a small seating area. It includes a microwave, coffee maker, and a refrigerator.

A hotel room with two beds, a bedside lamp, a bench, a mirror, and a door leading to another room.

A hotel lobby with a reception desk, seating area, and a television screen.

13. Holiday Inn Poplar Bluff by IHG

Poplar Bluff

Nathan

₩106,069

₩119,831 total

includes taxes & fees

Nov 15 - Nov 16

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

14. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

₩135,809

₩153,211 total

includes taxes & fees

Oct 22 - Oct 23

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

15. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

₩107,278

₩116,102 total

includes taxes & fees

Nov 1 - Nov 2

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

A swimming pool area with a clear pool, a lifeguard chair, and a sign indicating the pool's depth.

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

A reception desk with a modern design, a digital screen, and a sign indicating 'IHG' branding.

16. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

₩126,209

₩144,319 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

17. Super 8 by Wyndham Perryville

Perryville

Matthew

₩91,300

₩104,516 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

A hotel room with a brick wall, two beds, a desk with a TV, and a patterned carpet.

An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.

Two grey armchairs with green cushions, a small side table with a white lamp, and wall-mounted sconces.

18. Drury Inn & Suites Hayti Caruthersville

Hayti

Cynthia

₩131,566

₩149,953 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

19. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Darnetta

₩134,252

₩151,455 total

includes taxes & fees

Oct 25 - Oct 26

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel room with two beds, a desk, a chair, and a window with curtains.

A reception desk with a digital map of the USA, a wooden reception area, and a sign for 'MICROHOTEL BY JYNDHAMI'.

20. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

₩113,588

₩133,579 total

includes taxes & fees

Nov 15 - Nov 16

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Vacation Rentals in Southeast Missouri

Cabin

A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A bedroom with a wooden bed, a bench, and a window.

A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A covered porch with yellow chairs, a bench, and a small table.

A spacious living area with a kitchen island, dining table, and a television.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A red house with a wooden deck and stone steps leading to a porch.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"Our room was spacious, clean and the bed was super comfortable!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"We have stayed at the Pear Tree several times and never disappointed!! Great staff, clean rooms, generous breakfast. A special thanks to Lydia who took extra care to make our last stay remarkable. Thank you."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Very friendly & professional staff. Trustworthy room attendants, with attention to details. Beds comfortable. Everyone enjoyed the morning breakfast, with a good menu. Cocktail hour widely attended. Would definitely stay here again!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"The room was clean, the pillows were great and the bed was comfy. the dinner service and breakfast were very nice and the staff was helpful and friendly! 10/10"

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"We have visited the area many times in the past few years and have had terrible luck at hotels all around the area. This was such a breath of fresh air. The property was beautiful, the room was super clean, the staff was so pleasant and helpful. Breakfast was tasty and the bed was super comfortable. We have found out hotel when we come to town."

Hampton Inn Poplar Bluff

10/10 Excellent

"The staff at checking was pleasant but one older man kept downgrading the governor of my state. Although I agreed with much of east he said I thought it was inappropriate to push without knowing where I stood. The actual young man who checked me in was very nice and was not part of the political conversation. With that said I would still stay at this hotel in the future as it was otherwise a very pleasant stay. Good breakfast in the morning. The room was very quiet."

Hampton Inn Sikeston

10/10 Excellent

"Everyone was so nice. The rooms were clean and the breakfast had a good variety ."

Motel 6 Poplar Bluff, MO

8/10 Good

"They let pets stay free!!! No deposit no size limits."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"We have stayed here a number of times over 20 years. It’s always clean and well maintained. Breakfast is very good. Staff is always friendly and helpful."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

₩73,040

₩83,521 total

Nov 1 - Nov 2

includes taxes & fees

8/10 Very Good! (1,003 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

₩89,018

₩101,459 total

Nov 1 - Nov 2

includes taxes & fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

₩93,046

₩104,190 total

Oct 29 - Oct 30

includes taxes & fees

8/10 Very Good! (1,001 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

₩96,657

₩109,043 total

Oct 25 - Oct 26

includes taxes & fees

9.2/10 Wonderful! (1,004 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

₩95,597

₩111,704 total

Nov 4 - Nov 5

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

₩122,114

₩136,738 total

Nov 1 - Nov 2

includes taxes & fees

9.4/10 Exceptional! (985 reviews)

Hotels in Southeast Missouri with star-rating

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Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from ₩83,521

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Hampton Inn & Suites By Hilton Festus

4. Fort Davidson Hotel

5. Fairfield Inn & Suites by Marriott Poplar Bluff

6. Holiday Inn Express & Suites Perryville by IHG

7. Super 8 by Wyndham Farmington

8. Drury Inn & Suites Poplar Bluff

9. Crown Pointe Lodge, BW Signature Collection

10. Hampton Inn Poplar Bluff

11. Baymont Inn and Suites by Wyndham Farmington, MO

12. EC Reed's Mercantile and Hotel

13. Holiday Inn Poplar Bluff by IHG

14. Fairfield Inn & Suites by Marriott Cape Girardeau

15. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

16. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

17. Super 8 by Wyndham Perryville

18. Drury Inn & Suites Hayti Caruthersville

19. Drury Plaza Hotel Cape Girardeau Conference Center

20. Microtel Inn & Suites by Wyndham Sainte Genevieve

Vacation Rentals in Southeast Missouri

Sam A Baker State Park

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Urban Lofts

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Hayti Caruthersville

Hampton Inn Poplar Bluff

Hampton Inn Sikeston

Motel 6 Poplar Bluff, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia

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