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Find hotels in Medical Center District, San Antonio from ₩101,575

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Discover 4,352 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2745)
"Beautiful area, well cared for on the riverwalk. Saturday was very busy! We loved walking the riverwalk and seeing all the flowers and vegetation! Hotel was very nice and all employees very kind!"
The price is ₩217,787
₩277,211 total
includes taxes & fees
May 27 - May 28
Hotel Contessa
Exterior
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2133)
"Location"
The price is ₩257,651
₩309,134 total
includes taxes & fees
May 27 - May 28
Omni La Mansion del Rio
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1060)
"Close to the Riverwalk and very nice and clean"
The price is ₩258,827
₩310,061 total
includes taxes & fees
May 26 - May 27
Grand Hyatt San Antonio River Walk
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Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.2 out of 10, Wonderful, (2597)
"We took a quick two day trip to San Antonio and truly enjoyed our stay at this hotel. The location is excellent - you can literally walk out onto the riverwalk from the basement. The staff at the front desk were always helpful and friendly, and the free daily happy hour was awesome! The only negative I would add is that the property feels a little dated, but for a 48 hour stay, it was perfect for our needs. I would definitely stay again!"
The price is ₩172,356
₩203,724 total
includes taxes & fees
May 28 - May 29
Drury Plaza Hotel San Antonio Riverwalk
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very Good, (1320)
"The property is a bit dated but good value for money overall. There is no daily cleaning service so you need to book this in advance. The staff are very friendly and helpful and the daily parking rate is pretty standard for downtown San Antonio"
The price is ₩142,957
₩168,988 total
includes taxes & fees
Jun 2 - Jun 3
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Outdoor pool, sun loungers
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very Good, (2638)
"Lots of people walking the area & homeless camps"
The price is ₩126,746
₩149,825 total
includes taxes & fees
May 19 - May 20
Hampton Inn San Antonio-Downtown (River Walk)
Private pool
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1103)
"Great place! "
The price is ₩518,544
₩669,053 total
includes taxes & fees
May 26 - May 27
La Cantera Resort & Spa
Frette Italian sheets, premium bedding, pillowtop beds, in-room safe
Hotel Gibbs Downtown Riverwalk
3.5 star property
9.0 out of 10, Wonderful, (2812)
"Location, location, location!! That says a-lot, but the incredible breakfast was the icing on the cake! It was delicious! The building was built in 1909, so it’s older, but definitely upgraded. "
The price is ₩158,826
₩185,430 total
includes taxes & fees
May 20 - May 21
Hotel Gibbs Downtown Riverwalk
Breakfast, lunch, dinner served; Italian cuisine
The Westin Riverwalk, San Antonio
4.0 star property
8.6 out of 10, Excellent, (1046)
"Nice"
The price is ₩251,167
₩299,133 total
includes taxes & fees
May 27 - May 28
The Westin Riverwalk, San Antonio
Exterior
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
3.0 star property
8.4 out of 10, Very Good, (1010)
"Everything is great except for the parking. I think parking should be free!!! "
The price is ₩167,444
₩200,411 total
includes taxes & fees
May 27 - May 28
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Downtown
2.5 star property
8.6 out of 10, Excellent, (2321)
"The staff was super friendly and the room was clean. The breakfast was decent. I would stay there again. "
The price is ₩136,049
₩160,823 total
includes taxes & fees
May 19 - May 20
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Outdoor pool, sun loungers
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 star property
7.6 out of 10, Good, (2564)
"Food was decent "
The price is ₩113,271
₩133,896 total
includes taxes & fees
May 14 - May 15
La Quinta Inn & Suites by Wyndham San Antonio Airport
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2992)
"Everything was good, I don’t have any complaint "
The price is ₩130,234
₩153,948 total
includes taxes & fees
May 19 - May 20
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1262)
"the location of the hotel"
The price is ₩261,632
₩314,758 total
includes taxes & fees
May 19 - May 20
Canopy by Hilton San Antonio Riverwalk
Exterior
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, (1541)
"Very nice hotel"
The price is ₩243,027
₩287,280 total
includes taxes & fees
May 26 - May 27
Hilton Palacio Del Rio
Reception
Hilton Garden Inn San Antonio Downtown Riverwalk
4.0 star property
8.2 out of 10, Very Good, (1006)
"Beautiful hotel and rooms. Breafast brunch had nice options. Was not super happy to pay for hotel parking (Valet) of $42 a night. In addition, the street noise was a huge distraction at night. Music and sounds of engines of cars and trucks etc... Wish we would have had a room with better acoustics. Otherwise a very very enjoyable stay. Thanks and hope to be back in San Antonio again soon enough. "
The price is ₩140,618
₩171,013 total
includes taxes & fees
May 26 - May 27
Hilton Garden Inn San Antonio Downtown Riverwalk
Exterior
Crowne Plaza San Antonio Airport, an IHG Hotel
3.5 star property
8.4 out of 10, Very Good, (825)
"Very clean hotel and excellent shower head "
The price is ₩141,589
₩167,370 total
includes taxes & fees
Jun 9 - Jun 10
Crowne Plaza San Antonio Airport, an IHG Hotel
Front of property - evening/night
Courtyard Marriott Riverwalk
3.0 star property
8.6 out of 10, Excellent, (1006)
"I had a great stay from, checking in early to breakfast and the valet. Evryone was great. "
The price is ₩161,630
₩191,061 total
includes taxes & fees
May 19 - May 20
Courtyard Marriott Riverwalk
Lobby
Tru By Hilton San Antonio Downtown Riverwalk
2.5 star property
7.8 out of 10, Good, (1005)
"Pretty good hotel. Location was a little loud but understandable for area. Valet employee were super helpful."
The price is ₩126,746
₩147,976 total
includes taxes & fees
May 19 - May 20
Tru By Hilton San Antonio Downtown Riverwalk
Exterior
La Quinta Inn by Wyndham San Antonio Market Square
2.5 star property
7.6 out of 10, Good, (1218)
"This is an older hotel, and it's a little frayed around the edges, but it was clean, safe, and only a 15-minute walk to the center of the city. I'd stay here again. "
The price is ₩101,575
₩120,071 total
includes taxes & fees
May 14 - May 15
La Quinta Inn by Wyndham San Antonio Market Square
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Medical Center District

Hotels in top San Antonio neighborhoods Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

3 out of top 10 points of interest in this area
4/5(9,525 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Medical Center District hotels information

Number of reviews
34,109
Accommodation
4,352 hotels
Lowest Price
₩101,575
Highest Price
₩518,544

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Fairfield Inn & Suites by Marriott San Antonio Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and free parking. Other favorite options in the area include Atria Inn & Suites and Courtyard by Marriott Medical Center San Antonio.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Recent reviews of Medical Center District hotels

Hotel Gibbs Downtown Riverwalk

Hotel Gibbs Downtown Riverwalk

5/5 Excellent
"Location, location, location!! That says a-lot, but the incredible breakfast was the icing on the cake! It was delicious! The building was built in 1909, so it’s older, but definitely upgraded. "
A verified traveler from Odem stayed at Hotel Gibbs Downtown Riverwalk
Posted 12 hours ago
Hotel Gibbs Downtown Riverwalk