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Check prices for these dates

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Aug 26 - Aug 27
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Aug 27 - Aug 28
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Aug 29 - Aug 31
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Sep 5 - Sep 7

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Discover 4,580 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Medical Center District hotels

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Water park

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 star property
9.0 out of 10, Wonderful, (1002)
"Really enjoyed our stay."
The price is ₩132,948
₩214,543 total
includes taxes & fees
Sep 2 - Sep 3
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Pear Tree Inn San Antonio Airport
Restaurant

Pear Tree Inn San Antonio Airport

2.5 star property
9.4 out of 10, Exceptional, (1411)
"Wonderful stay"
The price is ₩106,978
₩126,459 total
includes taxes & fees
Sep 1 - Sep 2
Pear Tree Inn San Antonio Airport
The Westin San Antonio North
Indoor pool, outdoor pool

The Westin San Antonio North

4.0 star property
8.6 out of 10, Excellent, (1061)
"Great place to stay."
The price is ₩120,887
₩144,997 total
includes taxes & fees
Sep 4 - Sep 5
The Westin San Antonio North
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Lobby

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 star property
9.0 out of 10, Wonderful, (996)
"Clean rooms, friendly staff, and the breakfast was actually really good!"
The price is ₩127,835
₩149,248 total
includes taxes & fees
Sep 7 - Sep 8
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Courtyard by Marriott Medical Center San Antonio
Exterior

Courtyard by Marriott Medical Center San Antonio

3.0 star property
8.8 out of 10, Excellent, (1006)
"Very nice place to stay."
The price is ₩136,172
₩160,967 total
includes taxes & fees
Sep 2 - Sep 3
Courtyard by Marriott Medical Center San Antonio
San Antonio Marriott Northwest Medical Center
Cocktail bar

San Antonio Marriott Northwest Medical Center

3.5 star property
8.6 out of 10, Excellent, (1014)
"We recommend this hotel 😊"
The price is ₩123,666
₩146,963 total
includes taxes & fees
Aug 31 - Sep 1
San Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3.0 star property
8.6 out of 10, Excellent, (2894)
"Hotel was in a nice area with lots of dining options nearby. "
The price is ₩123,388
₩145,842 total
includes taxes & fees
Aug 27 - Aug 28
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Atria Inn & Suites
Front of property

Atria Inn & Suites

2.0 star property
7.4 out of 10, Good, (250)
"The staff was very friendly."
The price is ₩68,781
₩80,302 total
includes taxes & fees
Aug 27 - Aug 28
Atria Inn & Suites
SpringHill Suites by Marriott San Antonio Medical Center/NW
Premium bedding, pillowtop beds, in-room safe, desk

SpringHill Suites by Marriott San Antonio Medical Center/NW

3.0 star property
8.8 out of 10, Excellent, (1000)
"Friendly staff , clean room and great shopping options walking distance "
The price is ₩144,509
₩170,826 total
includes taxes & fees
Sep 1 - Sep 2
SpringHill Suites by Marriott San Antonio Medical Center/NW
Drury Inn & Suites San Antonio Northwest Medical Center
Lobby

Drury Inn & Suites San Antonio Northwest Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1265)
"Nice hotel, convient access to highway, gated parking."
The price is ₩138,937
₩164,226 total
includes taxes & fees
Sep 7 - Sep 8
Drury Inn & Suites San Antonio Northwest Medical Center
Park Inn by Radisson
Reception

Park Inn by Radisson

2.0 star property
7.2 out of 10, Good, (1001)
"Rooms were clean and staff was cordial and helpful. Would recommend."
The price is ₩84,621
₩98,795 total
includes taxes & fees
Sep 8 - Sep 9
Park Inn by Radisson
OYO Inn & Suites Medical Center San Antonio
Exterior

OYO Inn & Suites Medical Center San Antonio

2.0 star property
7.2 out of 10, Good, (214)
"Beautiful place to stay love it "
The price is ₩74,422
₩98,002 total
includes taxes & fees
Sep 17 - Sep 18
OYO Inn & Suites Medical Center San Antonio
Studio 6 San Antonio, Tx - Northwest Medical Center
Desk, laptop workspace, blackout drapes, free WiFi

Studio 6 San Antonio, Tx - Northwest Medical Center

2.0 star property
7.2 out of 10, Good, (170)
"The location was convenient and the price was very good. "
The price is ₩69,017
₩80,578 total
includes taxes & fees
Sep 4 - Sep 5
Studio 6 San Antonio, Tx - Northwest Medical Center
Flex Studios
Basic Room, Multiple Beds, Non Smoking | 1 bedroom, desk, iron/ironing board, free WiFi

Flex Studios

2.5 star property
6.0 out of 10, (480)
"Great central location in the medical center area, with easy and convenient highway access. "
The price is ₩63,278
₩74,800 total
includes taxes & fees
Aug 27 - Aug 28
Flex Studios
Motel 6 San Antonio, TX - Northwest Medical Center
Free WiFi, bed sheets

Motel 6 San Antonio, TX - Northwest Medical Center

2.0 star property
6.0 out of 10, (1000)
"Really enjoyed our stay"
The price is ₩63,904
₩75,520 total
includes taxes & fees
Sep 1 - Sep 2
Motel 6 San Antonio, TX - Northwest Medical Center
Studio 6 San Antonio, TX - Medical Center
1 bedroom, desk, laptop workspace, free WiFi

Studio 6 San Antonio, TX - Medical Center

2.0 star property
6.6 out of 10, (743)
"Everything perfect"
The price is ₩69,406
₩84,816 total
includes taxes & fees
Aug 28 - Aug 29
Studio 6 San Antonio, TX - Medical Center
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Free daily on-the-go breakfast

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

3.0 star property
6.6 out of 10, (1003)
"Quick check in and great breakfast"
The price is ₩99,211
₩115,828 total
includes taxes & fees
Sep 2 - Sep 3
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Best Western Plus Atrium Inn
Lobby

Best Western Plus Atrium Inn

2.5 star property
8.6 out of 10, Excellent, (1000)
"Great stay. "
The price is ₩125,459
₩144,278 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Plus Atrium Inn
Best Western Plus Roland Inn & Suites
Exterior

Best Western Plus Roland Inn & Suites

3.0 star property
8.6 out of 10, Excellent, (1004)
"Lovely and clean place to stay "
The price is ₩117,553
₩137,244 total
includes taxes & fees
Aug 27 - Aug 28
Best Western Plus Roland Inn & Suites
La Quinta by Wyndham San Antonio by Frost Bank Center
Exterior

La Quinta by Wyndham San Antonio by Frost Bank Center

3.0 star property
7.8 out of 10, Good, (1004)
"Amazing place to stay "
The price is ₩95,042
₩110,966 total
includes taxes & fees
Aug 27 - Aug 28
La Quinta by Wyndham San Antonio by Frost Bank Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Marion Koogler McNay Art Museum featuring art and interior views

Uptown

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Northwest Los Angeles Heights

If you're looking for some top things to see and do in Northwest Los Angeles Heights and surrounding area, you can visit Alamo and Alamodome.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

Top Medical Center District Hotel Reviews

Menger Hotel

Menger Hotel

10/10 Excellent
"This was my first time traveling alone, and I was a little nervous. I found staff to be extremely helpful and very pleasant. Each one ready to assist and answer any questions. Planning to return with my husband for a longer stay. I highly recommend the Menger hotel!!"
Rosa 3-night trip
Posted 2 days ago
Menger Hotel

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 119 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

USAA Corporate Office Headquarters, Cinemark San Antonio 16, and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.