A forested valley with autumn foliage, a rocky cliff, and a sunset.

Southern Illinois, Illinois hotel rooms at the Best Western

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Southern Illinois Best Western

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.
A spacious dining area with a long wooden table, multiple chairs, and pendant lighting.
A Best Western hotel with a modern facade, a parking lot, and a clear sky.
A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a framed artwork on the wall.

1. Best Western Delta Inn

Best Western Delta Inn
Effingham
United States
Susan
₩108,161
₩121,118 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Delta Inn
A modern living room with a sofa, chairs, a coffee station, and a dining area.
A modern kitchen with a central island, bar stools, and pendant lighting.
A reception desk with a blue accent wall, a framed welcome sign, and a flat-screen TV above it.
A hotel room with a large bed, a bedside table, a lamp, and a wall-mounted light fixture.

2. Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights
Fairview Heights
United States
LaShelle
₩116,961
₩132,142 total
includes taxes & fees
Oct 28 - Oct 29
Best Western St. Louis Fairview Heights
A self-service breakfast area with a coffee machine, refrigerated display case, and various food items.
A gym with treadmills, ellipticals, and weight machines.
A hotel room with a bed, a television, a desk, a coffee machine, and a bathroom visible through an open door.
A Best Western hotel with a parking lot and a covered entrance.

3. Best Western Marion Hotel

Best Western Marion Hotel
Marion
United States
Cornell
₩101,269
₩121,502 total
includes taxes & fees
Oct 27 - Oct 28
Best Western Marion Hotel
A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.
A hotel room with two beds, a desk, and a window with a view.
A reception area with a stone wall, a round mirror, a reception desk, and a computer setup.
A Best Western U.S. Inn with a modern design, featuring a covered entrance and a parking lot.

4. Best Western U. S. Inn

Best Western U. S. Inn
Nashville
United States
Steven
₩158,758
₩173,014 total
includes taxes & fees
Oct 25 - Oct 26
Best Western U. S. Inn
A hotel room with two beds, a desk, a chair, a TV, a lamp, and a painting on the wall.
A bar area with multiple stools, a bar counter, shelves of liquor bottles, and hanging pendant lights.
A modern restaurant with a bar area, multiple tables and chairs, and a kitchen in the background.
A modern hotel lobby with leather sofas, a flat-screen TV, and framed artwork on the walls.

5. Best Western Saluki Inn

Best Western Saluki Inn
Carbondale
United States
Bryan
₩111,880
₩131,285 total
includes taxes & fees
Nov 22 - Nov 23
Best Western Saluki Inn
A hotel lobby with a dining area, kitchen, and seating.
A hotel room with a large bed, a desk, a chair, a TV, and a nightstand with a lamp.
A gym with treadmills, elliptical machines, and free weights.
A modern lobby with a reception desk, seating area, and a large flat-screen TV mounted on the wall.

6. Best Western Heartland Inn

Best Western Heartland Inn
Mattoon
United States
Crystal
₩118,086
₩132,232 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Heartland Inn
A hotel room with a large bed, a desk, a chair, a TV, and a sofa.
A gym with treadmills, elliptical machines, and a stationary bike.
A modern hotel lobby with a brown sofa, a globe on a wooden stand, and a framed abstract painting on the wall.
A breakfast buffet setup with a microwave, glass display cases, and various food items.

7. Best Western Flora Inn

Best Western Flora Inn
Flora
United States
Terri
₩119,025
₩129,712 total
includes taxes & fees
Nov 2 - Nov 3
Best Western Flora Inn
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Southern Illinois Hotel Reviews

Best Western Delta Inn

Best Western Delta Inn

10/10 Excellent
"Great breakfast! The beds were so comfy! The staff was great!"
Melissa Rae 2-night trip
Posted 5 hours ago
Best Western Delta Inn
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

10/10 Excellent
"Clean room… a key factor in selecting a hotel. Spacious room. Convenient parking. Breakfast was average, but adequate. Have stayed before and will again."
Norman 1-night trip
Posted 18 hours ago
Baymont by Wyndham Effingham
Drury Inn & Suites Marion

Drury Inn & Suites Marion

10/10 Excellent
"Excellent very good High quality"
laurie 2-night trip
Posted 1 day ago
Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Staff was very friendly"
Karissa 3-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis O'Fallon, IL
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent
"The only downfall was the indoor pool. I thought it would be heated. It wasn't. The kids still went in but we're shivering."
Michele 3-night trip
Posted 5 days ago
Quality Inn O'Fallon - St. Louis - Shiloh

Explore a world of travel with Expedia