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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.6/10 Exceptional! (1,006 reviews)

Clean room, everyone helpful and pleasant.

Reviewed on Apr 27, 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...

8.4/10 Very Good! (1,000 reviews)

Bathroom had pee stains around the toilet. On their add they use a picture of a large beautiful room where you check in. Not This motel is old and run down.

Reviewed on Apr 22, 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

9.4/10 Exceptional! (1,004 reviews)

Friendly staff. Good food.

Reviewed on Apr 26, 2026

See all 655 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.