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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (1,949 reviews)

Room was clean. Kind of small. Very quiet. Little disappointed there's no in house breakfast. Parking is expensive

Reviewed on Mar 9, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

7.8/10 Good! (1,010 reviews)

It was ok. Pool needs cleaning.

Reviewed on Mar 9, 2026

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.4/10 Very Good! (638 reviews)

Nice staff, pool

Reviewed on Mar 2, 2026

See all 939 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.