Southeast Minnesota Luxury Vacations
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Top Luxury Southeast Minnesota Hotels
Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
- 2 min walk from Mayo Clinic
Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...
8.4/10 Very Good! (2,338 reviews)
"Perfect for the outpatient setting for Mayo. Definitely recommend using valet for just a little more it’s worth it and so easy!"
Reviewed on Oct 1, 2026
Med City Inn & Suites - Mayo Clinic Area
435 16th Ave Nw Rochester MN
- 26 min walk from Mayo Clinic
Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...
7.8/10 Good! (1,026 reviews)
"A terrible place- We arrived in the evening. The guy that checked us in didn't seem friendly. We went out and ate supper after check in. When we got back, it was late. We should have checked the room better before we left to eat. The ceiling in the bathroom had a big bulge, and the bathrm exhaust ..."
Reviewed on Sep 30, 2026
AmericInn by Wyndham Northfield
1320 Bollenbacher Dr Northfield MN
- 2 hours drive from Mayo Clinic
AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
