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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,164 reviews)

"I loved it was right across the street from Mayo Clinic. On Thursday evenings downtown they have a marvelous festival with music and so many vendors. You have to check out the fudge. The staff was great and I received immediate results from questions and requests."

Reviewed on Jun 26, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.4/10 Very Good! (664 reviews)

"When you rent a hotel room you expect it to be cleaned daily unless otherwise told. It is utter nonsense to come back to your room and have it not clean and told that's the policy. We pay to have our room cleaned. You can ASK if we don't need it done, but the assumption is to clean. Anyone else tired ..."

Reviewed on Jun 17, 2026

See all 917 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.