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Aug 21 - Aug 22
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Aug 22 - Aug 23
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Aug 22 - Aug 24
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Compare 585 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Great location "
The price is ₩125,685
₩144,498 total
includes taxes & fees
Aug 25 - Aug 26
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is ₩125,685
₩132,878 total
includes taxes & fees
Aug 25 - Aug 26
Drury Inn & Suites Jackson MO
Postcard Cabins St. Francois
Exterior

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (27)
"Sweet cabin"
The price is ₩124,303
₩186,348 total
includes taxes & fees
Aug 25 - Aug 26
Postcard Cabins St. Francois
Microtel Inn & Suites by Wyndham Sainte Genevieve
Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (588)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is ₩118,157
₩131,844 total
includes taxes & fees
Sep 7 - Sep 8
Microtel Inn & Suites by Wyndham Sainte Genevieve
Drury Inn & Suites Hayti Caruthersville
Lobby

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1000)
"We enjoyed our stay."
The price is ₩131,272
₩149,610 total
includes taxes & fees
Aug 31 - Sep 1
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Very nice property Friendly helpful staff"
The price is ₩107,529
₩123,605 total
includes taxes & fees
Aug 25 - Aug 26
Pear Tree Inn Sikeston
Holiday Inn Express & Suites Perryville by IHG
Exterior

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (497)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is ₩132,683
₩151,889 total
includes taxes & fees
Aug 24 - Aug 25
Holiday Inn Express & Suites Perryville by IHG
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby lounge

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (794)
"Hotel was very clean and the staff was friendly! I would stay again. "
The price is ₩138,269
₩156,210 total
includes taxes & fees
Aug 24 - Aug 25
Fairfield Inn & Suites by Marriott Poplar Bluff
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Excellent place to stay "
The price is ₩97,752
₩110,280 total
includes taxes & fees
Aug 25 - Aug 26
Pear Tree Inn Cape Girardeau Near the Medical Center
The Riverview
Grand Riverview Two Queen Room | 1 bedroom, premium bedding, pillowtop beds, in-room safe

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (392)
"Nice place to stay! everything was fun and clean."
The price is ₩147,068
₩165,913 total
includes taxes & fees
Aug 24 - Aug 25
The Riverview
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby lounge

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (125)
"The hotel was very clean and updated and the staff was super friendly and very informative!"
The price is ₩129,889
₩146,532 total
includes taxes & fees
Aug 28 - Aug 29
Fairfield Inn & Suites by Marriott Cape Girardeau
Crown Pointe Lodge, BW Signature Collection
Lobby

Crown Pointe Lodge, BW Signature Collection

2.5 star property
9.0 out of 10, Wonderful, (544)
"This is our second time staying at the hotel. It's clean, the staff is very friendly and it's right next door to the golf course we play."
The price is ₩187,306
₩213,247 total
includes taxes & fees
Sep 6 - Sep 7
Crown Pointe Lodge, BW Signature Collection
Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (739)
"Nice and clean hotel friendly service"
The price is ₩153,144
₩172,767 total
includes taxes & fees
Aug 31 - Sep 1
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Poplar Bluff
Terrace/patio

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (751)
"Excellent property, great location. "
The price is ₩135,336
₩151,541 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn Poplar Bluff
Shepherd Mountain Inn
Fridge, microwave, coffee/tea maker

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (290)
"Wonderful small town motel in a beautiful & quiet location."
The price is ₩150,839
₩164,750 total
includes taxes & fees
Aug 24 - Aug 25
Shepherd Mountain Inn
The Farmstead Hotel
Front of property

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (405)
"Great place. "
The price is ₩119,414
₩210,421 total
includes taxes & fees
Aug 23 - Aug 24
The Farmstead Hotel
Pinemark Inn & Suites
Front of property

Pinemark Inn & Suites

2.0 star property
9.6 out of 10, Exceptional, (1001)
"Great place to stay. "
The price is ₩194,750
₩213,214 total
includes taxes & fees
Aug 24 - Aug 25
Pinemark Inn & Suites
Super 8 by Wyndham Farmington
Exterior

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very Good, (577)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is ₩77,165
₩87,852 total
includes taxes & fees
Aug 27 - Aug 28
Super 8 by Wyndham Farmington
The Wildwood Hotel
Ballroom

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1555)
"Great place to stay."
The price is ₩123,185
₩148,958 total
includes taxes & fees
Sep 1 - Sep 2
The Wildwood Hotel
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Enjoy my stay here. Very nice room and the breakfast was nice"
The price is ₩125,685
₩141,775 total
includes taxes & fees
Aug 25 - Aug 26
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Aug 29 - Aug 31

Image gallery for Tiny Houses of French Village

House | Living area

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (3 reviews)
10% off
Price is ₩339,388
₩935,809 total
includes taxes & fees
Tiny Houses of French Village
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"This place is amazing. Employees are always friendly and treat you like family not like just another guest. "
Jonathan 1-night trip
Posted 3 days ago
Motel 6 Poplar Bluff, MO