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Jan 7 - Jan 8
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Jan 8 - Jan 9
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Jan 9 - Jan 11
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Jan 16 - Jan 18

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Our top choices for Defiance hotels

Suite, 1 King Bed, Non Smoking (Upgraded) | In-room safe, laptop workspace, blackout drapes, iron/ironing board
Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO
2.0 star property
St. Clair
7.2 out of 10, Good, (949)
"Was what I needed after a long drive."
United States
Michael
The price is ₩93,825
₩102,715 total
includes taxes & fees
Jan 14 - Jan 15
Super 8 by Wyndham St. Clair MO
Lobby
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (645)
"Isa a great place to stay I always enjoy it!"
United States
vicki
The price is ₩186,782
₩212,650 total
includes taxes & fees
Jan 11 - Jan 12
Best Western Plus Washington Hotel
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (857)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ₩159,271
₩191,119 total
includes taxes & fees
Jan 10 - Jan 11
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1009)
"Great hotel for the money"
United States
Jere
The price is ₩110,431
₩126,915 total
includes taxes & fees
Jan 11 - Jan 12
Comfort Suites St Charles - St Louis
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1000)
"Staff and hotel were amazing"
United States
Allison
The price is ₩166,496
₩193,007 total
includes taxes & fees
Jan 18 - Jan 19
Drury Plaza Hotel St. Louis St. Charles
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (30)
"Super clean , quiet place "
United States
Phoenix
The price is ₩128,865
₩152,575 total
includes taxes & fees
Jan 9 - Jan 10
WoodSpring Suites St Peters-OFallon
Lobby
Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (364)
"Excellent staff & very clean room"
United States
Karen
The price is ₩131,471
₩150,502 total
includes taxes & fees
Feb 2 - Feb 3
Quality Inn Near Six Flags St. Louis
Lobby
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.8 out of 10, Excellent, (1000)
"Breakfast was excellent along with clean comfortable beds. "
United States
Scott
The price is ₩176,907
₩203,314 total
includes taxes & fees
Jan 18 - Jan 19
Embassy Suites by Hilton St. Louis St. Charles
Free daily buffet breakfast
Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (642)
"The breakfast was delicious and contained a wide variety. The staff friendly and the rooms very clean. "
United States
Kim
The price is ₩155,883
₩187,951 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn & Suites St. Charles Old Town Area
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1001)
"Room was excellent and clean"
United States
catherine
The price is ₩92,305
₩106,105 total
includes taxes & fees
Jan 25 - Jan 26
Days Inn by Wyndham St Peters/St Charles
Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Washington

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very Good, (704)
"The staff was extremely nice & accommodating."
United States
Brenda
The price is ₩122,422
₩139,377 total
includes taxes & fees
Jan 13 - Jan 14
Super 8 by Wyndham Washington
Lobby sitting area
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.2 out of 10, Very Good, (1000)
"Clean room, great stay"
United States
Becky
The price is ₩121,842
₩141,247 total
includes taxes & fees
Jan 13 - Jan 14
Best Western Plus The Charles Hotel
Exterior
Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (522)
"Very helpful and friendly staff"
United States
TONY
The price is ₩205,605
₩234,854 total
includes taxes & fees
Jan 11 - Jan 12
Holiday Inn Express Warrenton by IHG
Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
River Sirens Hotel

River Sirens Hotel

River Sirens Hotel
2.5 star property
Washington
9.8 out of 10, Exceptional, (186)
"Great place"
United States
Herchel
River Sirens Hotel
Lobby lounge
Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (646)
"Clean room, friendly and professional staff, plus the included breakfast was a great perk."
United States
Marlene
The price is ₩185,160
₩211,916 total
includes taxes & fees
Jan 19 - Jan 20
Fairfield Inn & Suites Wentzville
Exterior
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1000)
"Everything was great!"
United States
Rita
The price is ₩156,972
₩180,424 total
includes taxes & fees
Jan 11 - Jan 12
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Quality Inn Foristell

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (920)
"The staff and breakfast were terrific."
United States
Kevin
The price is ₩107,074
₩120,940 total
includes taxes & fees
Jan 12 - Jan 13
Quality Inn Foristell
Suite, 2 Bedrooms | Premium bedding, down comforters, pillowtop beds, in-room safe
Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (761)
"The staff was very professional and the room was clean. I will definitely book here again"
United States
Ngozi
The price is ₩110,042
₩126,469 total
includes taxes & fees
Jan 11 - Jan 12
Candlewood Suites St Louis St Charles by IHG
Lobby
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1000)
"Great hotel! Clean, friendly staff, wonderful amenities!"
United States
Susan
The price is ₩159,257
₩183,075 total
includes taxes & fees
Jan 11 - Jan 12
Drury Inn & Suites St. Louis St. Peters
Exterior
Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
St. Charles
8.6 out of 10, Excellent, (776)
"Room was wonderful great location"
United States
Sandra
The price is ₩153,161
₩177,554 total
includes taxes & fees
Jan 25 - Jan 26
Tru by Hilton St. Charles St. Louis, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"Continental breakfast, clean rooms, polite and helpful hosts, good experience. Visit with family if two elderly as well, and they like the comfort and clean environment, then only concern no bottled waters in rooms. "
Jack 1-night trip
Posted 2 days ago
The Wildwood Hotel

More cheap stays in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is ₩91,219 per night from Jan 10 to Jan 11
₩91,219
₩104,829 total
Jan 10 - Jan 11
includes taxes & fees
6.6/10 (999 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and Busch Stadium. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.