Find hotels in Defiance, MO from ₩98,447

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Feb 22 - Feb 23
Tomorrow
Feb 23 - Feb 24
Next weekend
Feb 27 - Mar 1
In two weeks
Mar 6 - Mar 8

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Defiance hotels

Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (45 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is ₩128,718
₩152,400 total
includes taxes & fees
Feb 24 - Feb 25
WoodSpring Suites St Peters-OFallon
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (943 reviews)
" Clean room friendly staff easy access"
United States
Steve
The price is ₩109,410
₩123,580 total
includes taxes & fees
Mar 1 - Mar 2
Quality Inn Foristell
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,102 reviews)
"Great room, great people, great breakfast "
United States
Jaiden
The price is ₩129,079
₩149,071 total
includes taxes & fees
Feb 24 - Feb 25
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (391 reviews)
"Parking was easy and the room was nice."
United States
Martha
The price is ₩160,825
₩186,477 total
includes taxes & fees
Mar 1 - Mar 2
Holiday Inn Express & Suites St Peters by IHG
Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,003 reviews)
"Nice place and nice people "
United States
Columbus
The price is ₩102,034
₩116,549 total
includes taxes & fees
Mar 1 - Mar 2
Baymont by Wyndham Warrenton
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (663 reviews)
"Prompt service, quick check in. "
United States
Emily
The price is ₩195,536
₩223,790 total
includes taxes & fees
Mar 22 - Mar 23
Hampton Inn St. Louis Wentzville
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,006 reviews)
"Great hotel for the money"
United States
Jere
The price is ₩128,675
₩147,882 total
includes taxes & fees
Feb 26 - Feb 27
Comfort Suites St Charles - St Louis
Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (629 reviews)
"It all went well . Room has been remodeled it was nice ."
United States
Charles
The price is ₩86,053
₩98,294 total
includes taxes & fees
Mar 1 - Mar 2
Super 8 by Wyndham Warrenton
Free breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (209 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
The price is ₩131,900
₩152,329 total
includes taxes & fees
Feb 24 - Feb 25
Best Western Plus Fenton
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (662 reviews)
"Clean room and hotel with a nice breakfast, have stayed here two times while visiting family."
United States
Brooks
The price is ₩186,569
₩212,399 total
includes taxes & fees
Feb 25 - Feb 26
Best Western Plus Washington Hotel
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,004 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is ₩116,902
₩137,887 total
includes taxes & fees
Mar 9 - Mar 10
Comfort Inn & Suites St. Louis - O'Fallon
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,011 reviews)
"Comfortable room. Quiet even though next to interstate. Excellent food "
United States
Geo
The price is ₩159,075
₩182,858 total
includes taxes & fees
Mar 8 - Mar 9
Drury Inn & Suites St. Louis St. Peters
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (655 reviews)
"Hotel staff was friendly and room was very clean "
United States
Danielle
The price is ₩184,949
₩211,673 total
includes taxes & fees
Feb 26 - Feb 27
Fairfield Inn & Suites Wentzville
Exterior

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (522 reviews)
"Very helpful and friendly staff"
United States
TONY
The price is ₩156,371
₩178,616 total
includes taxes & fees
Mar 1 - Mar 2
Holiday Inn Express Warrenton by IHG
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,148 reviews)
"Clean place in friendly service"
United States
David
The price is ₩114,328
₩132,034 total
includes taxes & fees
Feb 24 - Feb 25
Wingate by Wyndham St. Louis/Fenton Route 66
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,004 reviews)
"Great location and friendly staff "
United States
Heather
The price is ₩152,986
₩175,822 total
includes taxes & fees
Mar 1 - Mar 2
Hampton Inn St. Charles St. Peters
Exterior

Courtyard by Marriott St. Louis West County

Courtyard by Marriott St. Louis West County
3.0 star property
Town and Country
9.0 out of 10, Wonderful, (461 reviews)
"Business friendly great staff."
United States
Elijah
The price is ₩215,089
₩247,327 total
includes taxes & fees
Mar 5 - Mar 6
Courtyard by Marriott St. Louis West County
Lobby

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very Good, (707 reviews)
"The staff was extremely nice & accommodating."
United States
Brenda
The price is ₩119,751
₩136,337 total
includes taxes & fees
Mar 24 - Mar 25
Super 8 by Wyndham Washington
Interior

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (519 reviews)
"Really cozy place to stay at!"
United States
Yufei
The price is ₩86,776
₩98,447 total
includes taxes & fees
Feb 24 - Feb 25
Economy Inn Wentzville
Lobby

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (366 reviews)
"Excellent staff & very clean room"
United States
Karen
The price is ₩135,949
₩155,627 total
includes taxes & fees
Feb 24 - Feb 25
Quality Inn Near Six Flags St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties
Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

10/10 Excellent
"Yes"
Danielle 1-night trip
Posted 11 hours ago
Crowne Plaza St. Louis Airport by IHG

More cheap stays in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is ₩91,115 per night from Feb 24 to Feb 25
₩91,115
₩104,710 total
Feb 24 - Feb 25
includes taxes & fees
6.6/10 (1,005 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Explore a world of travel with Expedia