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Find hotels in Defiance, MO from ₩87,166

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Compare 830 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Economy Inn Wentzville

2.0 star property
6.4 out of 10, (451)
"Best value around this location. Not going to be as nice as holiday Inn , but way better than most budget friendly places."
The price is ₩96,851
₩109,877 total
includes taxes & fees
Aug 25 - Aug 26
Economy Inn Wentzville

Inns at St. Albans

2.0 star property
10.0 out of 10, Exceptional, (1)
"Great little peaceful getaway for the weekend. Not a lot of food options nearby so you need to plan ahead, but really enjoyed our stay."
The price is ₩297,470
₩318,219 total
includes taxes & fees
Aug 27 - Aug 28
Inns at St. Albans

Extended Stay America Select Suites - St. Louis - Airport - Central

2.5 star property
7.0 out of 10, Good, (987)
"Clean and had good accommodation "
The price is ₩113,301
₩135,853 total
includes taxes & fees
Sep 7 - Sep 8
Extended Stay America Select Suites - St. Louis - Airport - Central

MainStay Suites St Louis Airport

3.0 star property
8.2 out of 10, Very Good, (295)
"Was a good stay and nice room"
The price is ₩136,974
₩163,367 total
includes taxes & fees
Aug 27 - Aug 28
MainStay Suites St Louis Airport

TownePlace Suites by Marriott Wentzville

3.0 star property
9.4 out of 10, Exceptional, (37)
"Great property, would recommend!!"
The price is ₩240,743
₩283,797 total
includes taxes & fees
Sep 1 - Sep 2
TownePlace Suites by Marriott Wentzville

Cedar Creek

3.0 star property
9.0 out of 10, Wonderful, (241)
"Beautiful property off the beaten path! We found this gem while traveling between cities and wanted to visit Hermann for a night. It was peaceful & quiet. The breakfast was wonderful and the staff was great! We took a nice walk along the golf course after breakfast and checked out the property. Highly recommend! "
The price is ₩203,704
₩217,913 total
includes taxes & fees
Aug 30 - Aug 31
Cedar Creek

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1002)
"The check in was super easy, there was a lady being trained, and they were both so nice! It was super fast, in the selection for the continental breakfast was good!! The area felt good.I would definitely stay here again!! Hotel stuff was super friendly :)"
The price is ₩78,587
₩91,545 total
includes taxes & fees
Sep 7 - Sep 8
Super 8 by Wyndham Eureka/Six Flags Nearby

Relax Inn Saint Charles

2.0 star property
6.4 out of 10, (998)
"Great place for traveling."
The price is ₩87,166
₩100,172 total
includes taxes & fees
Aug 25 - Aug 26
Relax Inn Saint Charles

Extended Stay America Suites St Louis St Peters

2.5 star property
7.0 out of 10, Good, (560)
"The front desk attendant was extremely helpful with checking in and answering questions about the dining and shopping in the area of the hotel."
The price is ₩102,096
₩117,359 total
includes taxes & fees
Aug 31 - Sep 1
Extended Stay America Suites St Louis St Peters

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1000)
"And nice hotel at a nice price "
The price is ₩118,711
₩140,020 total
includes taxes & fees
Sep 1 - Sep 2
Comfort Inn & Suites St. Louis - O'Fallon

Extended Stay America Select Suites St Louis Earth City

2.5 star property
6.6 out of 10, (858)
"I love staying at this ESA location. The staff is wonderful "
The price is ₩117,037
₩140,184 total
includes taxes & fees
Sep 14 - Sep 15
Extended Stay America Select Suites St Louis Earth City

Extended Stay America Suites St Louis Westport Central

2.5 star property
7.4 out of 10, Good, (985)
"Good place to stay."
The price is ₩119,527
₩138,620 total
includes taxes & fees
Aug 25 - Aug 26
Extended Stay America Suites St Louis Westport Central

Comfort Inn St. Louis Airport

3.0 star property
8.6 out of 10, Excellent, (894)
"Good experience during our stay. "
The price is ₩120,787
₩144,552 total
includes taxes & fees
Aug 25 - Aug 26
Comfort Inn St. Louis Airport

River Sirens Hotel

2.5 star property
9.8 out of 10, Exceptional, (165)
"Fantastic location in Washington MO. Our go to place for a quick escape from stress. Rooms ate spacious, clean, and close to the downtown riverfront."
The price is ₩179,008
₩203,816 total
includes taxes & fees
Aug 31 - Sep 1
River Sirens Hotel

Marriott St. Louis West

3.5 star property
8.6 out of 10, Excellent, (1000)
"Wonderful place!"
The price is ₩215,562
₩250,565 total
includes taxes & fees
Sep 6 - Sep 7
Marriott St. Louis West

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (895)
"Nice location amd staff were very nice would go there again!"
The price is ₩102,385
₩112,086 total
includes taxes & fees
Aug 25 - Aug 26
Super 8 by Wyndham St. Clair MO

Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd

2.5 star property
5.8 out of 10, (1000)
"The staff was wonderful and polite and helpful they need a raise!!!"
The price is ₩105,831
₩122,751 total
includes taxes & fees
Aug 25 - Aug 26
Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd

LAKEVIEWINN

2.5 star property
5.8 out of 10, (22)
"I felt like the place had permanent residents. Right outside my door was the community grill which had 5 or so people hanging out."
The price is ₩117,604
₩132,834 total
includes taxes & fees
Aug 25 - Aug 26
LAKEVIEWINN

Super 8 by Wyndham O'Fallon MO/St. Louis Area

2.0 star property
6.8 out of 10, (962)
"Great staff clean room"
The price is ₩92,907
₩109,583 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham Warrenton

2.0 star property
7.4 out of 10, Good, (582)
"Staff was extremely accommodating and friendly."
The price is ₩99,964
₩114,434 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Warrenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?
What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.