Find hotels in Defiance, MO from ₩98,842

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and La Quinta Inn & Suites by Wyndham St. Louis Westport. See all available top hotels, or vacation rentals in Defiance.

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. La Quinta Inn & Suites by Wyndham St. Louis Westport and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.