Serra Mesa, CA
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Serra Mesa Hotel Deals
Hard Rock Hotel San Diego
Clean room
Reviewed on Jan 20, 2026
Sheraton San Diego Resort
I stayed in one of the newly-remodeled rooms overlooking the pool/bay in the Marina Tower. Really lovely and the room was exceptionally well-appointed. Great view! The staff was also accomodating with arranging a day-rate for use of the room since I wasn't flying out until the evening. Would absolutely ...
Reviewed on Jan 19, 2026
Courtyard by Marriott San Diego Downtown Little Italy
Nice room. Great location
Reviewed on Jan 20, 2026
The Dana on Mission Bay
Beautiful view from room, clean, very nice staff
Reviewed on Jan 15, 2026
Pendry San Diego
Well decorated, super clean high touches
Reviewed on Jan 17, 2026
The DEXTRO Little Italy, BW Premier Collection
Great atmosphere
Reviewed on Jan 19, 2026
Other neighborhoods around Serra Mesa
Mission Valley
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Old Town San Diego
The ample dining options and beautiful seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
